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The male sibling presented with psychosis at age 16 years and cognitive and motor disturbance at age 25 years, whereas his elder sister, sharing the same mutation but showing less severe biochemical, neuroimaging and ocular motor parameters, presented with a similar schizophrenia\u2010like illness with associated cognitive and motor disturbance at age 31 years. Their illness onset, course and response to treatment mirrors the sex dimorphism seen in schizophrenia, and is suggestive of an interaction between the neurobiology of their metabolic disorder and sex differences in neurodevelopment.<\/jats:p>","DOI":"10.1007\/s10545-009-1173-1","type":"journal-article","created":{"date-parts":[[2009,7,15]],"date-time":"2009-07-15T23:46:54Z","timestamp":1247701614000},"page":"221-226","source":"Crossref","is-referenced-by-count":31,"title":["Gender dimorphism in siblings with schizophrenia\u2010like psychosis due to Niemann\u2010Pick disease type C"],"prefix":"10.1002","volume":"32","author":[{"given":"M.","family":"Walterfang","sequence":"first","affiliation":[{"name":"Neuropsychiatry Unit Royal Melbourne Hospital Level 2, John Cade Building, Royal Melbourne Hospital 3050 Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fietz","sequence":"additional","affiliation":[{"name":"Department of 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