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This review concentrates on motor disturbances as frequent and important symptoms of inborn errors of metabolism. A structured diagnostic approach is developed taking into account age\u2010dependent physiological developments and pathophysiological responses of gross and fine motor functions. A series of investigations are presented with the primary aim of early diagnosis of treatable conditions. The correct recognition and differentiation of movement disorders (ataxia, rigid akinetic syndrome (\u2018parkinsonism\u2019), dystonia, athetosis, tremor, and others), spasticity, and neuromuscular disorders, requires profound neurological expertise. A high level of suspicion and close interaction between paediatric neurologists and specialists in inborn errors of metabolism are indispensable to effectively and timely identify patients in whom motor disturbances are the presenting and\/or main symptom of an inborn error.<\/jats:p>","DOI":"10.1007\/s10545-009-1194-9","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T12:52:14Z","timestamp":1251895934000},"page":"618-629","source":"Crossref","is-referenced-by-count":41,"title":["Inborn errors of metabolism and motor disturbances in children"],"prefix":"10.1002","volume":"32","author":[{"given":"A.","family":"Garc\u00eda\u2010Cazorla","sequence":"first","affiliation":[{"name":"Neurology and Metabolism Department Hospital Sant Joan de D\u00e9u Barcelona Spain"},{"name":"Centre for Biomedical Research on Rare Diseases (CIBER\u2010ER) Instituto de Salud Carlos III Madrid Spain"},{"name":"Neurology Department Hospital Sant Joan de D\u00e9u Passeig Sant Joan de D\u00e9u, 2 Barcelona Esplugues 08950 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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