{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T10:58:07Z","timestamp":1762340287808},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,10,31]],"date-time":"2009-10-31T00:00:00Z","timestamp":1256947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004329","name":"Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Minnesota Muliphasic Personality Inventory (MMPI\u20102) is widely used in chronic illness and chronic pain populations to assess psychological functioning. We report the results of the first investigation using the MMPI\u20102 to assess psychological aspects of patients with Fabry disease. Fabry disease, an X\u2010linked lysosomal storage disorder, is a multisystem progressive disease affecting the kidney, heart, and central nervous system, and is particularly associated with chronic symptoms including pain. In this study, 28 patients with Fabry disease completed the MMPI\u20102 and a background questionnaire. Fabry disease patients scored significantly higher than the MMPI\u20102 normative sample on seven clinical scales (<jats:italic>Hs, D, Hy, Pd, Pa, Pt, Sc<\/jats:italic>) and two validity scales (<jats:italic>L, F<\/jats:italic>). Individuals with elevated scores on the <jats:italic>Hs, D<\/jats:italic>, and <jats:italic>Hy<\/jats:italic> scales tend to have somatic complaints, sadness, and emotional distress. Under stress, they may experience an increase in physical symptoms. Elevated <jats:italic>Pd, Pa, Pt<\/jats:italic>, and <jats:italic>Sc<\/jats:italic> scales suggest social maladjustment, suspiciousness, and feelings of isolation. An elevated <jats:italic>L<\/jats:italic> scale suggests defensiveness; a high score on <jats:italic>F<\/jats:italic> suggests emotional turmoil. When compared with cohorts of patients with Gaucher disease (GD), chronic heart disease (CRHD), and chronic pain, the Fabry disease patients had significantly higher scores than GD patients and CRHD patients on numerous clinical (<jats:italic>Hs, D, Si<\/jats:italic>), and validity (<jats:italic>F<\/jats:italic>) scales underscoring the relative amount of suffering and pain experienced by Fabry disease patients. No significant differences on any MMPI\u20102 scales were found between the Fabry disease patients and the pain patients, suggesting that Fabry disease patients may be comparable to pain patient populations.<\/jats:p>","DOI":"10.1007\/s10545-009-1254-1","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:59:21Z","timestamp":1258592361000},"page":"745-753","source":"Crossref","is-referenced-by-count":28,"title":["Psychological aspects of patients with Fabry disease"],"prefix":"10.1002","volume":"32","author":[{"given":"T. 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