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Dietary restriction of Phe creates a diet similar to a vegan diet, and many of the nutritional concerns and questions applicable to vegans who wish to avoid animal products are also relevant to patients with PKU. Owing to their nutritional characteristics, breast milk and breastfeeding should be given greater consideration as a useful food in patients with PKU and in those with other inborn errors of metabolism. Further key issues for consideration include the quality of the available amino acid substitutes, the neurotrophic and neuroprotective effects of added long\u2010chain polyunsaturated fatty acids (e.g. docosahexaenoic acid), micronutrient deficiencies, bone disease and antioxidant status. Long\u2010term dietary guidance and monitoring of the nutritional status of patients with PKU should be part of a follow\u2010up programme that continues for life.<\/jats:p>","DOI":"10.1007\/s10545-010-9043-4","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T16:40:34Z","timestamp":1265906434000},"page":"659-664","source":"Crossref","is-referenced-by-count":61,"title":["Nutritional issues in treating phenylketonuria"],"prefix":"10.1002","volume":"33","author":[{"given":"Fran\u00e7ois","family":"Feillet","sequence":"first","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des maladies h\u00e9r\u00e9ditaires du m\u00e9tabolisme de Nancy, INSERM U 954 H\u00f4pital d'Enfants, CHU Brabois All\u00e9e du Morvan Vandoeuvre les Nancy 54500 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Agostoni","sequence":"additional","affiliation":[{"name":"Department of Maternal and Pediatric Sciences, Fondazione IRCCS C\u00e0 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