{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:37:52Z","timestamp":1791027472833,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Albuterol, a selective beta\u2010adrenergic agonist, has been used experimentally in combination with exercise therapy in a few inherited neuromuscular disorders to increase muscle strength and muscle volume . We report on a 9\u2010year\u2010old boy with central core disease and mitochondrial dysfunction due to compound heterozygous <jats:italic>RYR1<\/jats:italic> mutations receiving albuterol treatment for 1 year. Throughout the period of albuterol administration, the patient underwent an aerobic exercise regime of training sessions three times a week that lasted 20 min each. No side effects of albuterol use were seen. Significant clinical progress, including self care, sitting up, raising arms above the shoulders, independent feeding, and better speech and writing were observed compared with minimal development of these abilities in the previous years on physiotherapy. Improved forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>) score was detected and increased muscle strength was noted: progress was measured using various functional tests and assessment scales. The only complication observed was a mild progression of the joint contractures, possibly due to an unbalance between the flexor and extensor musculature. In general, in this pilot study in a complex case of metabolic myopathy our patient has shown promising results following albuterol treatment and aerobic exercise therapy.<\/jats:p>","DOI":"10.1007\/s10545-010-9085-7","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T06:06:48Z","timestamp":1272953208000},"page":"205-209","source":"Crossref","is-referenced-by-count":16,"title":["Successful use of albuterol in a patient with central core disease and mitochondrial dysfunction"],"prefix":"10.1002","volume":"33","author":[{"given":"L. T. W.","family":"Schreuder","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Neurology, Nijmegen Centre for Mitochondrial Disorders Radboud University Nijmegen Medical Centre P.O Box 9101 Nijmegen HB 6500 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. W. G.","family":"Nijhuis\u2010van der Sanden","sequence":"additional","affiliation":[{"name":"Department of Paediatric Physical Therapy Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"de Hair","sequence":"additional","affiliation":[{"name":"Pediatric Department M\u00e1xima Medical Center Veldhoven Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Paediatric Physical Therapy Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wortmann","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Nijmegen Centre for Mitochondrial Disorders Radboud University Nijmegen Medical Centre P.O Box 9101 Nijmegen HB 6500 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Bok","sequence":"additional","affiliation":[{"name":"Pediatric Department M\u00e1xima Medical Center Veldhoven Veldhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Morava","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Nijmegen Centre for Mitochondrial Disorders Radboud University Nijmegen Medical Centre P.O Box 9101 Nijmegen HB 6500 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"9","article-title":"Methods for measurement of muscle function. Methodological aspects, reference values for children, and clinical applications","volume":"20","author":"B\u00e4ckman E","year":"1988","journal-title":"Scand J Rehabil Med Suppl"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20368"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-5101.2003.00728.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1019984714528"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-003-0038-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20179"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.062414"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl149"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bse0420013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-31"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.609"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.8.1434"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1402"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00108-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-821173"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20696"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244435.27645.54"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.08.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050405"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl282"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1139\/H08-122"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn296"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021678"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-010-9085-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:23:42Z","timestamp":1694759022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-010-9085-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,5]]},"references-count":23,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1007\/s10545-010-9085-7"],"URL":"https:\/\/doi.org\/10.1007\/s10545-010-9085-7","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,5]]}}}