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Symptoms of cobalamin deficiency in children differ with age, presenting a continuum from subtle developmental delay to life\u2010threatening clinical conditions. The symptoms may be difficult to detect, particularly in infants, and there tends to be a diagnostic delay of several months in this age group. Several reports show that even moderate deficiency in children may be harmful, and long\u2010term consequences of neurological deterioration may persist after cobalamin deficiency has been treated. Given the crucial role of cobalamin for normal growth and development, possible widespread infantile deficiency needs attention. Cobalamin deficiency should be considered a differential diagnosis in children with subtle symptoms, and strategies to prevent cobalamin deficiency in mothers and children should be addressed.<\/jats:p>","DOI":"10.1007\/s10545-010-9119-1","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T09:24:03Z","timestamp":1274865843000},"page":"111-119","source":"Crossref","is-referenced-by-count":54,"title":["Cobalamin status in children"],"prefix":"10.1002","volume":"34","author":[{"given":"Anne\u2010Lise","family":"Bj\u00f8rke\u2010Monsen","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Biochemistry Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Magne","family":"Ueland","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Biochemistry Haukeland University Hospital Bergen Norway"},{"name":"Section of Pharmacology, Institute of Medicine University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2575-6_14"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0559-4_6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2004.tb00069.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26947A"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.7.14.7901104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00531-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.684"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5347.1713"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90090-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.10.016"},{"key":"e_1_2_9_12_1","first-page":"209","article-title":"Vitamin B12 deficiency, infertility and recurrent fetal loss","volume":"46","author":"Bennett M","year":"2001","journal-title":"J Reprod Med"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.1.7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.624"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2716"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S117"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/124.8.1179"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601236"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28082"},{"key":"e_1_2_9_20_1","volume-title":"Nutrient adequacy of exclusive breast feeeding for the term infant during the first six months of life","author":"Butte NF","year":"2002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.357"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","unstructured":"CarmelR GreenR RosenblattDS WatkinsD(2003)Update on cobalamin folate and homocysteine.Hematology Am Soc Hematol Educ Program 62\u201381.","DOI":"10.1182\/asheducation-2003.1.62"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.02.005"},{"key":"e_1_2_9_24_1","unstructured":"CastleWB HaleTH(1998)Vitamin B12. 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