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Intelligence, language, vision\u2010spatial abilities, memory, sensorimotor abilities, and attention and executive functions were tested with a computerized test battery as well as standard paper and pencil tests. The results were compared to known age\u2010based norms. In addition, all patients were screened for lifelong DSM\u2010IV Axis\u2010I and Axis\u2010II psychiatric diagnoses, and 4 were interviewed by a psychiatrist. Performance on most cognitive measures was within average range. All measures of information processing speed were significantly reduced, as were some measures of executive functions. Ten out of 16 patients met DSM\u2010IV criteria for Axis I or Axis II diagnoses at some point in their lives. This preliminary study delineates a psychiatric and cognitive phenotype in AFD patients and contributes to the growing field of characterizing behavioral phenotypes of patients with genetic diseases. We suggest that psychiatric and neuro\u2010psychological evaluation be included in the patient's evaluation.<\/jats:p>","DOI":"10.1007\/s10545-010-9133-3","type":"journal-article","created":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T08:42:03Z","timestamp":1276504923000},"page":"429-436","source":"Crossref","is-referenced-by-count":23,"title":["Psychiatric and cognitive profile in Anderson\u2010Fabry patients: a preliminary study"],"prefix":"10.1002","volume":"33","author":[{"given":"Perri","family":"Segal","sequence":"first","affiliation":[{"name":"Department of Psychology Hebrew University Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Kohn","sequence":"additional","affiliation":[{"name":"Psychiatry Department Hadassah Hebrew University Medical Center Jerusalem 91120 Israel"},{"name":"Herman Dana Division of Child and Adolescent Psychiatry Hadassah Hebrew University Medical Center Jerusalem 91120 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