{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:58Z","timestamp":1786980838433,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T00:00:00Z","timestamp":1279670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blood sampling for newborn screening cannot be standardized as for example blood collection in adults after an overnight fast. Therefore the influence of postprandial changes and individual variation is valuable information for the assessment of sensitivity and specificity of newborn screening for certain disorders. We have analyzed 92 pairs of dried blood samples taken pre\u2010 and one hour postprandially, respectively. We have determined the mean increase in metabolite concentration and calculated its significance. Individual variation after an overnight fast in healthy adults (n\u2009=\u20093) was between 12 and 32% (SD). Postprandial increases of acylcarnitines were mostly not significant and not exceeding 10%. Postprandial increase of amino acids was highly significant for most proteinogenic amino acids, but not for all. With the collected data we were able to estimate that mainly decreased levels of methionine and, to a lesser extent, of free carnitine could be \u201cmasked\u201d by postprandial increases of the respective metabolites, and could therefore lead to false negative results for the detection of disorders of cobalamin metabolism and carnitine transporter deficiency.<\/jats:p>","DOI":"10.1007\/s10545-010-9167-6","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T07:07:43Z","timestamp":1279609663000},"page":"235-239","source":"Crossref","is-referenced-by-count":5,"title":["Postprandial changes of amino acid and acylcarnitine concentrations in dried blood samples"],"prefix":"10.1002","volume":"33","author":[{"given":"Ralph","family":"Fingerhut","sequence":"first","affiliation":[{"name":"University Children`s Hospital Z\u00fcrich Switzerland"},{"name":"Swiss Newborn Screening Laboratory University Children`s Hospital Steinwiesstr. 75 Z\u00fcrich CH\u20108032 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"De Jesus Silva Arevalo","sequence":"additional","affiliation":[{"name":"Metabolic and genetic clinic, UNICAR\u2010Foundation Aldo Castaneda Pediatric Area Guatemala City Guatemala Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias R.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"University Children`s Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"H\u00e4berle","sequence":"additional","affiliation":[{"name":"University Children`s Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Rohrbach","sequence":"additional","affiliation":[{"name":"University Children`s Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s Weinfeld \u00c1valos","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Metabolic and genetic clinic, UNICAR\u2010Foundation Aldo Castaneda Pediatric Area Guatemala City Guatemala Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Mar\u00eda Dard\u00f3n","family":"Fresse","sequence":"additional","affiliation":[{"name":"Metabolic and genetic clinic, UNICAR\u2010Foundation Aldo Castaneda Pediatric Area Guatemala City Guatemala Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Leticia","family":"Polanco","sequence":"additional","affiliation":[{"name":"Metabolic and genetic clinic, UNICAR\u2010Foundation Aldo Castaneda Pediatric Area Guatemala City Guatemala Central America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Torresani","sequence":"additional","affiliation":[{"name":"University Children`s Hospital Z\u00fcrich 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