{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:54:35Z","timestamp":1788058475337,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T00:00:00Z","timestamp":1288137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The porphyrias comprise a heterogeneous group of rare, primarily hereditary, metabolic diseases caused by a partial deficiency in one of the eight enzymes involved in the heme biosynthesis. Our aim was to assess whether acute or cutaneous porphyria has been associated with excess risks of adverse pregnancy outcomes. A population\u2010based cohort study was designed by record linkage between the Norwegian Porphyria Register, covering 70% of all known porphyria patients in Norway, and the Medical Birth Registry of Norway, based on all births in Norway during 1967\u20132006. The risks of the adverse pregnancy outcomes preeclampsia, delivery by caesarean section, low birth weight, premature delivery, small for gestational age (SGA), perinatal death, and congenital malformations were compared between porphyric mothers and the rest of the population. The 200 mothers with porphyria had 398 singletons during the study period, whereas the 1,100,391 mothers without porphyria had 2,275,317 singletons. First\u2010time mothers with active acute porphyria had an excess risk of perinatal death [adjusted odds ratio (OR) 4.9, 95% confidence interval (CI) 1.5\u201316.0], as did mothers with the hereditable form of porphyria cutanea tarda (PCT) (3.0, 1.2\u20137.7). Sporadic PCT was associated with an excess risk of SGA [adjusted relative risk (RR) 2.0, 1.2\u20133.4], and for first\u2010time mothers, low birth weight (adjusted OR 3.4, 1.2\u201310.0) and premature delivery (3.5, 1.2\u201310.5) in addition. The findings suggest women with porphyria should be monitored closely during pregnancy.<\/jats:p>","DOI":"10.1007\/s10545-010-9231-2","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T12:05:00Z","timestamp":1288094700000},"page":"217-223","source":"Crossref","is-referenced-by-count":31,"title":["Excess risk of adverse pregnancy outcomes in women with porphyria: a population\u2010based cohort study"],"prefix":"10.1002","volume":"34","author":[{"given":"Mette Christophersen","family":"Toll\u00e5nes","sequence":"first","affiliation":[{"name":"The Norwegian Porphyria Centre (NAPOS), Laboratory of Clinical Biochemistry Haukeland University Hospital Bergen NO\u20105021 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasne Karine","family":"Aarsand","sequence":"additional","affiliation":[{"name":"The Norwegian Porphyria Centre (NAPOS), Laboratory of Clinical Biochemistry Haukeland University Hospital Bergen NO\u20105021 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Sandberg","sequence":"additional","affiliation":[{"name":"The Norwegian Porphyria Centre (NAPOS), Laboratory of Clinical Biochemistry Haukeland University Hospital Bergen NO\u20105021 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