{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:57:28Z","timestamp":1782503848668,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T00:00:00Z","timestamp":1302739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Profound mental retardation in phenylketonuria (PKU) can be prevented by a low phenylalanine (Phe) diet. However, even patients treated early have inconsistently shown deficits in several frontal lobe\u2013related neuropsychological tasks such as the widely accepted Stroop task. The goal of this study was to investigate whether adult patients exhibit altered brain activation in Stroop\u2010related locations in comparison to healthy controls and if an acute increase in blood Phe levels in patients has an effect on activation patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen male, early\u2010treated patients with classic PKU (mean\u2009\u00b1\u2009SD age: 31.0\u2009\u00b1\u20095.2 years) and 15 male healthy controls (32.1\u2009\u00b1\u20096.4 years) were compared using a color\u2010word matching Stroop task in a functional magnetic resonance imaging (fMRI) study at 3T. Participants were scanned twice, and an oral Phe load (100 mg\/kg body weight) was administered to patients prior to one of the fMRI sessions (placebo\u2010controlled). Activity in brain regions that are known to be involved in Stroop tasks was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PKU patients exhibited poorer accuracy in incongruent trials. Reaction times were not significantly different. There were no consistent differences in BOLD activations in Stroop\u2010associated brain regions. The oral Phe administration had no significant effect on brain activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither a generally slower task performance nor distinctively altered functioning of brain networks involved in a task representing a subset of dopamine\u2010dependent executive functions could be proven. Decreased accuracy and inconsistent findings in posterior areas necessitate further study of frontal\u2010lobe functioning in PKU patients in larger study samples.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10545-011-9318-4","type":"journal-article","created":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T12:46:18Z","timestamp":1302698778000},"page":"711-721","source":"Crossref","is-referenced-by-count":20,"title":["Tackling frontal lobe\u2013related functions in PKU through functional brain imaging: a Stroop task in adult patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Benedikt","family":"Sundermann","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster Albert\u2010Schweitzer\u2010Str. 33 Muenster 48149 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Pfleiderer","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster Albert\u2010Schweitzer\u2010Str. 33 Muenster 48149 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald E.","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Schwindt","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology University Hospital Muenster Albert\u2010Schweitzer\u2010Str. 33 Muenster 48149 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Weglage","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6ran","family":"Lepsien","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Muenster Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-006-9002-x"},{"key":"e_1_2_8_3_1","volume-title":"Farbe\u2010Wort\u2010Interferenztest nach J. R. Stroop (FWIT)","author":"B\u00e4umler G","year":"1985"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2004.12.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957228"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01249231"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2080765"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2005.05.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BOLI.0000042985.02049.ff"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.7.4.367"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.18.4.613"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.19.5.679"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(84)90133-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.10.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20127"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20501"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.6.911"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm082"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-03072.1994"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/1166208","article-title":"Prefrontal cortex cognitive deficits in children treated early and continuously for PKU","volume":"62","author":"Diamond A","year":"1997","journal-title":"Monogr Soc Res Child Dev"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200206000-00017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0445-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330508"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2006.01.033"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.03.042"},{"key":"e_1_2_8_27_1","volume-title":"Functional magnetic resonance imaging","author":"Huettel SA","year":"2009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/1074"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.315"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/1099"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200007)10:3<120::AID-HBM30>3.0.CO;2-8"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600571"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854040490501718"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005646206348"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0399-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.082602.092845"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00491918"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.109.2.163"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90653-1"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.12.2229"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.06.003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01054-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199811000-00004"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1542\/peds.112.S4.1580","article-title":"Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria","volume":"112","author":"M\u00f6ller HE","year":"2003","journal-title":"Pediatrics"},{"key":"e_1_2_8_45_1","first-page":"137","volume-title":"PKU and BH4\u2014advances in phenylketonuria and tetrahydrobiopterin","author":"M\u00f6ller HE","year":"2006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-007-9021-2"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1005"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1993.tb11552.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.201.2.8888233"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5017"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000055867.83310.9E"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200004270-00042"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.02.041"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2027-z"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.12.003"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073191105276375"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014370"},{"key":"e_1_2_8_59_1","volume-title":"Co\u2010planar stereotaxic atlas of the human brain","author":"Talairach JTP","year":"1988"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(96)00774-5"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245830"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20325"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01953938"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005587915468"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01700.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014259"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.1990.tb03560.x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.15.2.221"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0110-1"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0665"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.05.008"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-011-9318-4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-011-9318-4","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-011-9318-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:41:09Z","timestamp":1694810469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-011-9318-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,14]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1007\/s10545-011-9318-4"],"URL":"https:\/\/doi.org\/10.1007\/s10545-011-9318-4","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,14]]}}}