{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:19Z","timestamp":1786980799631,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T00:00:00Z","timestamp":1316044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this case series we report 12 pregnancies, in women treated at four centres, illustrating some of the issues that may be encountered during pregnancy by women with inherited metabolic disease. We discuss how specific pregnancy, labour and delivery issues for mothers with methylmalonic acidemia, homocystinuria, propionic acidemia, glutaric acidemia type 1, ornithine transcarbamylase (OTC) deficiency and 3\u2010hydroxy\u20103\u2010methylglutaric(HMG)\u2010CoA lyase deficiency were managed and the outcome for the mother and child in each case. Eight of the 12 pregnancies resulted in the successful delivery of a liveborn infant. Several women experienced decompensation of their condition during pregnancy or the post\u2010partum period. There was one maternal death in a women with 3\u2010hydroxy\u20103\u2010methylglutaric(HMG)\u2010CoA lyase deficiency. Pre\u2010pregnancy counselling and co\u2010management of high risk medical patients by obstetricians and specialist physicians with an understanding of the relationship between pregnancy and inherited metabolic disease is essential.<\/jats:p>","DOI":"10.1007\/s10545-011-9389-2","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T07:57:08Z","timestamp":1315987028000},"page":"419-424","source":"Crossref","is-referenced-by-count":70,"title":["A series of pregnancies in women with inherited metabolic disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Janneke G","family":"Langendonk","sequence":"first","affiliation":[{"name":"Centre for Lysosomal and Metabolic diseases Departments of Internal Medicine and Pediatrics, Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan CP","family":"Roos","sequence":"additional","affiliation":[{"name":"Consultant Inherited Metabolic Disease, Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Internal Mailbox 92 8\u201011 Queen Square London WC1N 3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Angus","sequence":"additional","affiliation":[{"name":"Centre for Lysosomal and Metabolic diseases Departments of Internal Medicine and Pediatrics, Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Lysosomal and Metabolic diseases Departments of Internal Medicine and Pediatrics, Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois PJ","family":"Karstens","sequence":"additional","affiliation":[{"name":"Centre for Lysosomal and Metabolic diseases Departments of Internal Medicine and Pediatrics, Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes BC","family":"de Klerk","sequence":"additional","affiliation":[{"name":"Centre for Lysosomal and Metabolic diseases Departments of Internal Medicine and Pediatrics, Erasmus MC Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charl\u00e9","family":"Maritz","sequence":"additional","affiliation":[{"name":"Consultant Inherited Metabolic Disease, Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Internal Mailbox 92 8\u201011 Queen Square London WC1N 3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfeg","family":"Ben\u2010Omran","sequence":"additional","affiliation":[{"name":"Clinical and Metabolic Genetics, Weill Cornell Medical College, Department of Pediatrics Hamad Medical Corporation P.O.BOX. 3050 Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Williamson","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology Dept. of Surgery and Cancer, Imperial College London Du Cane Rd London W12 0NN UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin H","family":"Lachmann","sequence":"additional","affiliation":[{"name":"Consultant Inherited Metabolic Disease, Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Internal Mailbox 92 8\u201011 Queen Square London WC1N 3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Murphy","sequence":"additional","affiliation":[{"name":"Consultant Inherited Metabolic Disease, Charles Dent Metabolic Unit National Hospital for Neurology and Neurosurgery Internal Mailbox 92 8\u201011 Queen Square London WC1N 3BG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,15]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222307"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283319127"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1256s"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11437.x"},{"issue":"1","key":"e_1_2_4_6_1","first-page":"1","article-title":"Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer: 2006\u20132008. 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