{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T02:12:31Z","timestamp":1743819151574},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Free asymmetric dimethylarginine (ADMA) is a competitive inhibitor of the nitric oxide synthases (NOS). Suppression of nitric oxide (NO) synthesis increases the risk of atherosclerosis. Nevertheless, in the condition of oxidative stress, NOS blockade by ADMA may exert protective effects. Protein metabolism is altered in patients with phenylketonuria (PKU) on dietary treatment and as shown recently, oxidative stress is high in PKU. Since free ADMA concentrations are determined by both protein metabolism and oxidative stress we hypothesized, that free ADMA levels may be elevated in PKU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Sixteen patients with PKU on dietary treatment (mean age 10.1\u2009\u00b1\u20095.2 yrs), and 91 healthy children (mean age 11.6\u2009\u00b1\u20093.7 yrs) participated in a cross sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADMA, total homocysteine (tHcy) and blood glucose were lower and the L\u2010arginine\/ADMA ratio was higher in PKU patients compared to controls. No significant correlation was present between phenylalanine (Phe) concentrations, protein intake, and lipid profile, history of cardiovascular disease or ADMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In contrast to our hypothesis, ADMA was lower and the L\u2010arginine\/ADMA ratio was higher in PKU patients. Therefore, in PKU patients, the regulating function of ADMA on NO synthesis is altered and may thus contribute to oxidative stress.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10545-011-9448-8","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T15:31:10Z","timestamp":1327937470000},"page":"817-821","source":"Crossref","is-referenced-by-count":21,"title":["Free asymmetric dimethylarginine (ADMA) is low in children and adolescents with classical phenylketonuria (PKU)"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Huemer","sequence":"first","affiliation":[{"name":"Department of Pediatrics Landeskrankenhaus Bregenz Carl Pedenz Str. 2 Bregenz 6900 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Simma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Landeskrankenhaus Feldkirch Carinagasse 47 Feldkirch 6807 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mayr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Landeskrankenhaus Bregenz Carl Pedenz Str. 2 Bregenz 6900 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"M\u00f6slinger","sequence":"additional","affiliation":[{"name":"University Children's Hospital W\u00e4hringer G\u00fcrtel 18\u201020 Vienna 1090 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"M\u00fchl","sequence":"additional","affiliation":[{"name":"Centogene Campus Vienna Biocenter 5 Vienna 1030 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Schmid","sequence":"additional","affiliation":[{"name":"University Institute for Clinical Chemistry M\u00fcllner Hauptstra\u00dfe 48 Salzburg 5020 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ulmer","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Informatics and Health Economics Innsbruck Medical University Sch\u00f6pfstrasse 41 Innsbruck 6020 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.A.","family":"Bodamer","sequence":"additional","affiliation":[{"name":"University Children's Hospital M\u00fcllner Hauptstra\u00dfe 48 Salzburg 5020 Austria"},{"name":"Institute for Inherited Metabolic Diseases Paracelsus Medical University M\u00fcllner Hauptstra\u00dfe 48 Salzburg 5020 Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164110366053"},{"key":"e_1_2_7_3_1","first-page":"159","article-title":"Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy","volume":"58","author":"Beltowski J","year":"2006","journal-title":"Pharmacological Reports."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.196"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.104786"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.7.1965"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1558"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP42672"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/080370500439371"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200104000-00016"},{"key":"e_1_2_7_12_1","unstructured":"KanzelmeyerN TsikasD Chobanyan\u2010J\u00fcrgensK BeckmannB VaskeB IllsingerS DasAM L\u00fcckeT(2011)Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria.Amino Acidsdoi:10.1007\/s00726\u2010011\u20100892\u20104 [Epub ahead of print]"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.354"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027109.14149.67"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.300"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20080079"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014226"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.09.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.03.019"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01561.x"},{"issue":"493","key":"e_1_2_7_21_1","first-page":"e1","article-title":"Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study","volume":"152","author":"Schulze F","year":"2006","journal-title":"Am Heart J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(03)00033-3"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-011-9448-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:31:28Z","timestamp":1694809888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-011-9448-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,31]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1007\/s10545-011-9448-8"],"URL":"https:\/\/doi.org\/10.1007\/s10545-011-9448-8","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,31]]}}}