{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:33:19Z","timestamp":1786980799623,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,5]],"date-time":"2012-05-05T00:00:00Z","timestamp":1336176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Life expectancy of patients with glycogen storage disease (GSD) type I has improved considerably, opening new problems correlated with adult age. In females polycystic ovaries (PCOs) has been described as frequently associated with the disease, however successful pregnancies have been reported. Whether or not GSD I is associated with impaired reproductive function is still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Data about female patients with GSD Ia and Ib, who were 16 years or older, were obtained from clinical records and interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 32 women with GSD I (25 GSD Ia, 7 GSD Ib), median age 26 years (range 16\u201355), were included. 9\/32 patients had delayed menarche, 17\/32 had irregular cycles, 8\/22 had documented polycystic ovaries. Five successful spontaneous pregnancies in four patients with GSD Ia and two in a woman with GSD Ib were reported. The latter had development and enlargement of hepatic adenomas during pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite the high prevalence of irregular menstruation cycles and polycystic ovaries, fertility seems not to be impaired in women with GSD I. During pregnancy monitoring for adenoma development is mandatory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10545-012-9490-1","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T01:55:05Z","timestamp":1336096505000},"page":"83-89","source":"Crossref","is-referenced-by-count":34,"title":["Fertility and pregnancy in women affected by glycogen storage disease type I, results of a multicenter Italian study"],"prefix":"10.1002","volume":"36","author":[{"given":"Annalisa","family":"Sechi","sequence":"first","affiliation":[{"name":"Regional Coordinator Centre for Rare Diseases University Hospital Santa Maria della Misericordia Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Deroma","sequence":"additional","affiliation":[{"name":"Regional Coordinator Centre for Rare Diseases University Hospital Santa Maria della Misericordia Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annunziata","family":"Lapolla","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paci","sequence":"additional","affiliation":[{"name":"Department of Paediatrics San Paolo Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Melis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Burlina","sequence":"additional","affiliation":[{"name":"Division of Inherited Metabolic Diseases, Department of Paediatrics University Hospital Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carubbi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology, Metabolism and Geriatrics University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Rigoldi","sequence":"additional","affiliation":[{"name":"Metabolic Unit San Gerardo Hospital Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Di Rocco","sequence":"additional","affiliation":[{"name":"II Division of Pediatrics Giannina Gaslini Children's Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1521","volume-title":"The metabolic and molecular bases of inherited disease","author":"Chen YT","year":"2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"DagliAI LeePJ CorreiaCE RodriguezC BhattacharyaK SteinkraussL StanleyCA WeinsteinDA(2010)Pregnancy in glycogen storage disease type Ib: gestational care and report of first successful deliveries.J Inherit Metab Dis. 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