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Here, we studied the direct influence of Miglustat on the enzymatic function of the major disaccharidases of the intestinal epithelium. Our findings show that an immediate effect of Miglustat is its interference with carbohydrate digestion in the intestinal lumen via reversible inhibition of disaccharidases that cleave \u03b1\u2010glycosidically linked carbohydrates. Higher non physiological concentrations of Miglustat can partly affect lactase activity. We further show that the inhibition of the disaccharidases function by Miglustat is mainly competitive and does not occur via alteration of the enzyme folding.<\/jats:p>","DOI":"10.1007\/s10545-012-9523-9","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T13:38:58Z","timestamp":1347543538000},"page":"949-954","source":"Crossref","is-referenced-by-count":28,"title":["Miglustat\u2010induced intestinal carbohydrate malabsorption is due to the inhibition of \u03b1\u2010glucosidases, but not \u03b2\u2010galactosidases"],"prefix":"10.1002","volume":"35","author":[{"given":"Mahdi","family":"Amiri","sequence":"first","affiliation":[{"name":"Department of Physiological Chemistry University of Veterinary Medicine Hannover Buenteweg 17 Hannover 30559 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan Y.","family":"Naim","sequence":"additional","affiliation":[{"name":"Department of Physiological Chemistry University of Veterinary Medicine Hannover Buenteweg 17 Hannover 30559 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80263-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00384-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9368-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02161-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-075960"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.3.838"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.07.020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90203-W"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2410427"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198707000-00115"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77693-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.4.685"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.12.023"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06976.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(73)90434-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250601094543"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-012-9523-9","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s10545-012-9523-9","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-012-9523-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:22:20Z","timestamp":1694809340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-012-9523-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,14]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1007\/s10545-012-9523-9"],"URL":"https:\/\/doi.org\/10.1007\/s10545-012-9523-9","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,14]]}}}