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The choroid plexus, site for the blood\u2010CSF barrier, has been suggested to be particularly important in maintaining brain barrier function in development. We investigated the expression of Nrf2\u2010 and detoxification\u2010system genes in choroid plexus following systemic LPS injections, unilateral cerebral hypoxia\u2010ischemia (HI) as well as the combination of LPS and HI (LPS\/HI). Plexuses were collected at different time points after LPS, HI and LPS\/HI in 9\u2010day old mice. mRNA levels of Nrf2 and many of its target genes were analyzed by quantitative PCR. Cell death was analyzed by caspase\u20103 immunostaining and TUNEL. LPS caused down\u2010regulation of the Nrf2\u2010system genes while HI increased expression at earlier time points. LPS exposure prior to HI prevented many of the HI\u2010induced gene increases. None of the insults resulted in any apparent cell death to choroidal epithelium. These data imply that the function of the inducible anti\u2010oxidant system in the choroid plexus is down\u2010regulated by inflammation, even if choroid cells are not structurally damaged. Further, LPS prevented the endogenous antioxidant response following HI, suggesting the possibility that the choroid plexus may be at risk if LPS is united with an insult that increases oxidative stress such as hypoxia\u2010ischemia.<\/jats:p>","DOI":"10.1007\/s10545-012-9551-5","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T16:20:28Z","timestamp":1351527628000},"page":"479-490","source":"Crossref","is-referenced-by-count":16,"title":["Expression of the Nrf2\u2010system at the blood\u2010CSF barrier is modulated by neonatal inflammation and hypoxia\u2010ischemia"],"prefix":"10.1002","volume":"36","author":[{"given":"Barbara","family":"D'Angelo","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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