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Ear, nose, throat (ENT) and respiratory problems are very common in patients with MPS and are often among the first symptoms to appear. Typical features of MPS include upper and lower airway obstruction and restrictive pulmonary disease, which can lead to chronic rhinosinusitis or chronic ear infections, recurrent upper and lower respiratory tract infections, obstructive sleep apnoea, impaired exercise tolerance, and respiratory failure. This review provides a detailed overview of the ENT and respiratory manifestations that can occur in patients with MPS and discusses the issues related to their evaluation and management.<\/jats:p>","DOI":"10.1007\/s10545-012-9555-1","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T08:58:06Z","timestamp":1352883486000},"page":"201-210","source":"Crossref","is-referenced-by-count":139,"title":["Respiratory and sleep disorders in mucopolysaccharidosis"],"prefix":"10.1002","volume":"36","author":[{"given":"Kenneth I.","family":"Berger","sequence":"first","affiliation":[{"name":"Department Medicine, Physiology and Neuroscience, Andr\u00e9 Cournand Pulmonary Physiology Laboratory, Bellevue Hospital New York University School of Medicine New York NY USA"},{"name":"Department of Medicine, Physiology and Neuroscience New York University School of Medicine 550 First Ave, Room RR108 New York NY 10016 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