{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T05:40:24Z","timestamp":1694842824166},"reference-count":3,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe a patient with the m.3243A&gt;G mitochondrial DNA mutation who developed sepsis caused by <jats:italic>Streptococcus constellatus<\/jats:italic>. In the acute phase of illness, abnormally high uptake of <jats:sup>18<\/jats:sup>F\u2010FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but remained clearly elevated. We did not observe high adrenal FDG uptake as in the patient described here among 30 patients with <jats:italic>Staphylococcus aureus<\/jats:italic> sepsis that were investigated with identical imaging protocol. In sepsis, oxygen consumption and metabolic rate are increased compared to normal metabolism. The observed high adrenal FDG uptake during sepsis in this patient probably reflects the acute metabolic stress induced by the infection. Interestingly, in repeated imaging six months later, the adrenal SUVs had diminished but were still abnormally high: this suggests constant high levels of metabolic stress associated with the mitochondrial disorder.<\/jats:p>","DOI":"10.1007\/s10545-014-9685-8","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T17:04:02Z","timestamp":1392829442000},"page":"863-864","source":"Crossref","is-referenced-by-count":1,"title":["Constant high adrenal FDG uptake in PET\/CT associated with mitochondrial disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Mika H.","family":"Martikainen","sequence":"first","affiliation":[{"name":"Division of Clinical Neurosciences University of Turku and Turku University Hospital Kiinamyllynkatu 4\u20108 Turku 20520 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Hohenthal","sequence":"additional","affiliation":[{"name":"Division of Medicine University of Turku and Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Piril\u00e4","sequence":"additional","affiliation":[{"name":"Division of Medicine University of Turku and Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine and Turku PET Centre University of Turku and Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199307000-00015"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2002.126035"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000159689.00755.7f"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-014-9685-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:56:36Z","timestamp":1694757396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-014-9685-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":3,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1007\/s10545-014-9685-8"],"URL":"https:\/\/doi.org\/10.1007\/s10545-014-9685-8","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}