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Hematopoietic stem cell (HSC) gene therapy indeed represents a valid alternative to conventional transplantation when a compatible donor is not available and recent success confirmed the great potential of this approach. First clinical trials performed with gamma retroviral vectors were promising and guaranteed clinical benefits to the patients. On the other hand, the outcome of severe adverse events as the development of hematological abnormalities highlighted the necessity to develop a safer platform to deliver the therapeutic gene. Self\u2010inactivating (SIN) lentiviral vectors (LVVs) were studied to overcome this hurdle through their preferable integration pattern into the host genome. In this review, we describe the recent advancements achieved both in vitro and at preclinical level with LVVs for the treatment of Wiskott\u2010Aldrich syndrome (WAS), chronic granulomatous disease (CGD), ADA deficiency (ADA\u2010SCID), Artemis deficiency, RAG1\/2 deficiency, X\u2010linked severe combined immunodeficiency (\u03b3chain deficiency, SCIDX1), X\u2010linked lymphoproliferative disease (XLP) and immune dysregulation, polyendocrinopathy, enteropathy, X\u2010linked (IPEX) syndrome.<\/jats:p>","DOI":"10.1007\/s10545-014-9690-y","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T15:52:33Z","timestamp":1394553153000},"page":"525-533","source":"Crossref","is-referenced-by-count":18,"title":["Lentiviral vectors for the treatment of primary immunodeficiencies"],"prefix":"10.1002","volume":"37","author":[{"given":"Giada","family":"Farinelli","sequence":"first","affiliation":[{"name":"Department of Pediatrics Children's Hospital Bambino Ges\u00f9 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