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The observation that mutations in the <jats:italic>GBA<\/jats:italic> gene represent the most common genetic risk factor for PD so far only came into focus because of astute clinical observation of Gaucher patients and their families. In this review, we (i) outline how <jats:italic>GBA<\/jats:italic> was identified as a genetic risk factor for Parkinsonism, (ii) present clinical characteristics of <jats:italic>GBA<\/jats:italic>\u2010associated Parkinsonism, (iii) discuss possible mechanisms of the underlying pathogenesis in <jats:italic>GBA<\/jats:italic>\u2010associated Parkinsonism, and (iv) provide an outlook on potentially new areas of research and treatment that arise from this important discovery.<\/jats:p>","DOI":"10.1007\/s10545-014-9714-7","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T12:53:42Z","timestamp":1401800022000},"page":"643-648","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The significance of <i>GBA<\/i> for Parkinson's disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Kathrin","family":"Brockmann","sequence":"first","affiliation":[{"name":"Department of 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