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In particular S\u2010palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl acyltransferases \u2013 PAT) or remove (acyl protein thioesterases) palmitate from proteins. Protein palmitoylation is an important process that dynamically regulates the assembly and compartmentalization of many neuronal proteins at specific subcellular sites. Enzymes that regulate protein palmitoylation are critical for several biological processes. To date, eight palmitoylation related genes have been reported to be associated with human disease. 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