{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:17:12Z","timestamp":1791278232353,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uncooked cornstarch (UCCS) is a widely used treatment strategy for patients with hepatic glycogen storage disease (GSD). It has been observed that GSD\u2010patients display different metabolic responses to different cornstarches. The objective was to characterize starch fractions and analyze the digestion of different starches in a dynamic gastrointestinal in vitro model. The following brands of UCCS were studied: Argo\u00ae and Great Value\u00ae from the United States of America; Brazilian Maizena Duryea\u00ae and Yoki\u00ae from Brazil; Dutch Maizena Duryea\u00ae from the Netherlands. Glycosade\u00ae, a modified starch, and sweet polvilho, a Brazilian starch extracted from cassava, were also studied. The starch fractions were analyzed by glycemic TNO index method and digestion analyses were determined by the TIM\u20101 system, a dynamic, computer\u2010controlled, in vitro gastrointestinal model, which simulates the stomach and small intestine. The final digested amounts were between 84 and 86 % for the UCCS and Glycosade\u00ae, but was 75.5 % for sweet povilho. At 180 min of the experiment, an important time\u2010point for GSD patients, the digested amount of the starches corresponded to 67.9\u201371.5 for the UCCS and Glycosade\u00ae, while it was 55.5 % for sweet povilho. In an experiment with a mixture of sweet polvilho and Brazilian Maizena Duryea\u00ae, a final digested amount of 78.4 % was found, while the value at 180 min was 61.7 %. Sweet polvilho seems to have a slower and extended release of glucose and looks like an interesting product to be further studied as it might lead to extended normoglycemia in GSD\u2010patients.<\/jats:p>","DOI":"10.1007\/s10545-014-9763-y","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T09:01:28Z","timestamp":1410771688000},"page":"529-536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["In vitro digestion of starches in a dynamic gastrointestinal model: an innovative study to optimize dietary management of patients with hepatic glycogen storage diseases"],"prefix":"10.1002","volume":"38","author":[{"given":"Tati\u00e9le","family":"Nalin","sequence":"first","affiliation":[{"name":"Post\u2010Graduation Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Venema","sequence":"additional","affiliation":[{"name":"The Netherlands Organization for Applied Scientific Research (TNO) Delft The Netherlands"},{"name":"Beneficial Microbes Consultancy Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Glycogen Storage Disease Program, Division of Pediatric Endocrinology, Department of Pediatrics University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina F. M","family":"de Souza","sequence":"additional","affiliation":[{"name":"Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid D. S.","family":"Perry","sequence":"additional","affiliation":[{"name":"Food and Nutrition Research Centre, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"},{"name":"Health Unit Universidade do Extremo Sul Crici\u00fama Crici\u00fama Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario T. R.","family":"van Wandelen","sequence":"additional","affiliation":[{"name":"The Netherlands Organization for Applied Scientific Research (TNO) Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet","family":"van Rijn","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center of Groningen University of Groningen Hanzeplein 1 Groningen RB 9700 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Peter A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center of Groningen University of Groningen Hanzeplein 1 Groningen RB 9700 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida V. D.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Post\u2010Graduation Program in Genetics and Molecular Biology Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"},{"name":"Medical Genetics Service, Hospital de Cl\u00ednicas de Porto Alegre Porto Alegre Brazil"},{"name":"Department of Genetics Universidade Federal do Porto Alegre Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry G. J.","family":"Derks","sequence":"additional","affiliation":[{"name":"Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Center of Groningen University of Groningen Hanzeplein 1 Groningen RB 9700 The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28443"},{"key":"e_1_2_8_3_1","unstructured":"BaliDS ChenY GoldsteinJL(2010)Glycogen storage disease type I. 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