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Some prenatal imaging findings can be suggestive of such conditions\u2014especially in cases of consanguinity and\/or recurrence of symptoms\u2014after exclusion of the most frequent nonmetabolic etiologies. Most of these prenatal imaging findings are nonspecific. They include mainly ascites and hydrops fetalis, intrauterine growth restriction (IUGR), central nervous system (CNS) anomalies, echogenic kidneys, epiphyseal stippling, craniosynostosis, and a wide spectrum of dysostoses. These anomalies can be isolated, but in most cases, an IEM is suggested by an association of features. It must be stressed that the diagnosis of an IEM in the prenatal period is based on a close collaboration between specialists in fetal imaging, medicine, genetics, biology, and pathology.<\/jats:p>","DOI":"10.1007\/s10545-016-9992-3","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T05:19:50Z","timestamp":1479359990000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antenatal manifestations of inborn errors of metabolism: prenatal imaging findings"],"prefix":"10.1002","volume":"40","author":[{"given":"Laurent","family":"Guibaud","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Imagerie P\u00e9diatrique et F\u0153tale H\u00f4pital Femme M\u00e8re Enfant Lyon Bron France"},{"name":"Centre Pluridisciplinaire de Diagnostic Pr\u00e9natal H\u00f4pital Femme M\u00e8re Enfant Lyon Bron France"},{"name":"Universit\u00e9 Claude Bernard Lyon I, 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