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Consequently, <jats:italic>N<\/jats:italic>\u2010sulphoglucosamine sulphohydrolase enzyme activity is reduced resulting in impaired catabolism of heparan sulphate. After an asymptomatic period, patients typically show a progressive loss of cognitive and motor skills, with death often during the second decade of life. The diagnostic criteria of autism spectrum disorders (ASD) include impaired communication and social interactions, as well as displays of repetitive behaviours and fixed interests. Children with MPS\u2010IIIA have been shown to exhibit decreased social communicative behaviours from approximately 3\u20134 years of age but behavioural stereotypies are mostly absent. In this study, we investigated whether a mouse model of MPS\u2010IIIA exhibited ASD\u2010like symptoms. The BTBR T<jats:sup>+<\/jats:sup><jats:italic>Itpr3<\/jats:italic><jats:sup>tf<\/jats:sup>\/J inbred mouse model of autism was used as a positive control. Male MPS\u2010IIIA and BTBR mice were less sociable compared with unaffected C57BL\/6 male mice in the reciprocal social approach test administered at 20 weeks of age. Alternations in the frequency of social interactions was not evident at earlier stages of the disease course, suggesting an acquisition of ASD\u2010like social behaviours. Stereotypical behaviours were not evident in male MPS\u2010IIIA mice in the marble\u2010burying test nor was the quality of nest constructed by mice affected. Collectively, these data suggest that MPS\u2010IIIA mice acquire autistic social behaviours similar to the human condition, and thus they may be useful for elucidating symptom generating mechanisms and novel treatments for ASD.<\/jats:p>","DOI":"10.1007\/s10545-018-0160-9","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T13:49:29Z","timestamp":1520516969000},"page":"669-677","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MPS\u2010IIIA mice acquire autistic behaviours with age"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-7714","authenticated-orcid":false,"given":"Adeline A.","family":"Lau","sequence":"first","affiliation":[{"name":"Childhood Dementia Research Group, Hopwood Centre for Neurobiology, Nutrition and Metabolism Theme South Australian Health and Medical Research Institute (SAHMRI) PO Box 11060 Adelaide South Australia 5001 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Tamang","sequence":"additional","affiliation":[{"name":"Childhood Dementia Research Group, Hopwood Centre for Neurobiology, Nutrition and Metabolism Theme South Australian Health and Medical Research Institute (SAHMRI) PO Box 11060 Adelaide South Australia 5001 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M.","family":"Hemsley","sequence":"additional","affiliation":[{"name":"Childhood Dementia Research Group, Hopwood Centre for Neurobiology, Nutrition and Metabolism Theme South Australian Health and Medical Research Institute (SAHMRI) PO Box 11060 Adelaide South Australia 5001 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"issue":"82","key":"e_1_2_12_2_1","first-page":"50978","article-title":"Marble burying and nestlet shredding as tests of 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