{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:06:40Z","timestamp":1780340800779,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>McArdle disease is an inborn disorder of muscle glycogen metabolism that produces exercise intolerance, and has been recently associated with low values \u200b\u200bof lean mass (LM) and bone mineral content (BMC) and density (BMD) in affected adults. Here we aimed to study whether this bone health problem begins in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty children and adolescents were evaluated: 10 McArdle disease and 30 control children (mean age of both groups, 13\u2009\u00b1\u20092y). Body composition was evaluated by dual\u2010energy X\u2010ray absorptiometry and creatine kinase (CK) levels were determined in the patients as an estimate of muscle damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Legs bone mass was significantly lower in patients than in controls (\u221236% for BMC and\u2009\u221222% for BMD). Moreover, patients had significantly higher LM values in the legs than controls, whereas no difference was found for fat mass. CK levels were positively associated with LM in McArdle patients. A correlation was found between LM and BMD variables in the control group but not in McArdle patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have identified a \u2018non\u2010osteogenic muscle hypertrophy\u2019 in children with McArdle disease. This phenomenon warrants special attention since low osteogenesis at an early age predicts a high risk for osteoporosis later in life.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10545-018-0170-7","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T08:39:46Z","timestamp":1522226386000},"page":"1037-1042","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Non\u2010osteogenic muscle hypertrophy in children with McArdle disease"],"prefix":"10.1002","volume":"41","author":[{"given":"I.","family":"Rodr\u00edguez\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"GENUD Toledo Research Group Universidad de Castilla\u2010La Mancha Avda Carlos III s\/n Toledo 45071 Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Santalla","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Madrid Spain"},{"name":"Department of Sport and Computer Science, Section of Physical Education and Sports, Faculty of Sport Universidad Pablo de Olavide Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"D\u00edez\u2010Bermejo","sequence":"additional","affiliation":[{"name":"Research Institute Hospital 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mungu\u00eda\u2010Izquierdo","sequence":"additional","affiliation":[{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Madrid Spain"},{"name":"Department of Sport and Computer Science, Section of Physical Education and Sports, Faculty of Sport Universidad Pablo de Olavide Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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