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Self\u2010monitoring of blood glucose is typically done 3\u20136 times per day, and may not sufficiently capture periods of asymptomatic hypoglycemia, particularly during sleep. Continuous glucose monitoring systems (CGMS) provide 24\u2010h continuous glucose data and have been used effectively in diabetes mellitus to monitor metabolic control and optimize treatment. This is a relatively new approach in GSDs with only a handful of studies exploring this modality. In this study we used Dexcom CGMS to study the glycemic profile of 14 pediatric and six adult patients with GSD I, III, and IX. A total of 176 days of CGMS data were available. The CGMS was found to be a reliable tool in monitoring glucose levels and trends at all times of the day with good concordance with finger\u2010stick glucose values. This study revealed that in addition to overnight hypoglycemia, CGMS can uncover previously undetected, subclinical, low glucose levels during daytime hours. Additionally, the CGMS detected daytime and overnight hyperglycemia, an often overlooked concern in liver GSDs. The CGMS with concurrent dietary adjustments made by a metabolic dietitian improved metabolic parameters and stabilized blood glucose levels. The CGMS was found to be a safe, effective, and reliable method for optimizing treatment in patients with GSD I, III, and IX.<\/jats:p>","DOI":"10.1007\/s10545-018-0200-5","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T08:19:15Z","timestamp":1527236355000},"page":"917-927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Role of continuous glucose monitoring in the management of glycogen storage disorders"],"prefix":"10.1002","volume":"41","author":[{"given":"Mrudu","family":"Herbert","sequence":"first","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Duke University Medical Center 905 South LaSalle Street, GSRB1 Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surekha","family":"Pendyal","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Duke University Medical Center 905 South LaSalle Street, GSRB1 Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mugdha","family":"Rairikar","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Duke University Medical Center 905 South LaSalle Street, GSRB1 Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Halaby","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Duke University Medical Center 905 South LaSalle Street, GSRB1 Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Duke University School of Medicine Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya S.","family":"Kishnani","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics Duke University Medical Center 905 South LaSalle Street, GSRB1 Durham NC 27710 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2482"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.01.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1989"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19975"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02498"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2010.03006.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814532203"},{"key":"e_1_2_9_9_1","unstructured":"FDA(2016)Dexcom G5 Mobile Continuous Glucose Monitoring System. 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