{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:39:35Z","timestamp":1740123575262,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"M\u00e4rta and Nasvells Stiftelse"},{"name":"ALF and RUFU"},{"name":"Centre for Integrated Research on Culture and Society (CIRCUS, Uppsala University): Anxiety, an Interdisciplinary Research Network","award":["226301800"],"award-info":[{"award-number":["226301800"]}]},{"DOI":"10.13039\/501100007051","name":"Uppsala University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Topogr"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tardive dyskinesia is a involuntary hyperkinetic disorder which usually occurs in older patients after long-term treatment with antipsychotic drugs. These dyskinesias are mostly irreversible and are frequently expressed in the tongue, cheeks, mandible, perioral area and other regions of the face. In this theoretical study we asked the question, why does tardive dyskinesia often have orofacial predominance? What might be the underlying neural network structure which contributes to this propensity? Graph analysis of high-level cortico-striato-thalamo-cortical network structure suggests a connectivity bottleneck. The number of walks of different lengths from the substantia nigra pars reticulata (SNr) to other vertices, as well as the returning cycles are the lowest in the network, which may indicate a higher damage susceptibility of this node. Analysis was also performed on published data from a recent high resolution histological study on cortico-striato-thalamo-cortical networks in rodents. Finer network partitioning and adjacency matrices demonstrated that the SNr has a heterogeneous connectivity structure and the number of local walks from nodes neighboring orofacial neural representation is higher, indicating possible early compensatory escape routes. However, with more extensive SNr damage the larger circuit compensation might be limited. This area of inquiry is important for future research, because identifying key vulnerable structures may provide more targeted therapeutical interventions.<\/jats:p>","DOI":"10.1007\/s10548-022-00931-y","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T14:03:16Z","timestamp":1672668196000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Why Does Tardive Dyskinesia Have Oro-facial Predominance? A Network Analysis"],"prefix":"10.1007","volume":"36","author":[{"given":"Krisztina","family":"Szaliszny\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,2]]},"reference":[{"issue":"6","key":"931_CR1","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1152\/jn.00579.2018","volume":"120","author":"V C\u00e1ceres-Ch\u00e1vez","year":"2018","unstructured":"C\u00e1ceres-Ch\u00e1vez V, Hern\u00e1ndez-Mart\u00ednez R, P\u00e9rez-Ortega J et al (2018) Acute dopamine receptor blockade in substantia nigra pars reticulata: a possible model for drug-induced Parkinsonism. J Neurophysiol 120(6):2922\u20132938","journal-title":"J Neurophysiol"},{"key":"931_CR2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fneur.2014.00242","volume":"5","author":"A Cenci","year":"2014","unstructured":"Cenci A (2014) Presynaptic mechanisms of L-DOPA-induced dyskinesia: the findings, the debate, and the therapeutic implications. Front Neurol 5:242","journal-title":"Front Neurol"},{"issue":"3","key":"931_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/0306-4522(89)90405-3","volume":"33","author":"A Cools","year":"1989","unstructured":"Cools A, Spooren W, Bezemer R et al (1989) Anatomically distinct output channels of the caudate nucleus and orofacial dyskinesia: critical role of the subcommissural part of the globus pallidus in oral dyskinesia. Neuroscience 33(3):535\u2013542","journal-title":"Neuroscience"},{"issue":"1","key":"931_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41531-021-00276-6","volume":"8","author":"R Cury","year":"2022","unstructured":"Cury R, Pavese N, Aziz T et al (2022) Gaps and roadmap of novel neuromodulation targets for treatment of gait in parkinson\u2019s disease. NPJ Parkinsons Dis 8(1):8","journal-title":"NPJ Parkinsons Dis"},{"issue":"8","key":"931_CR5","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1523\/JNEUROSCI.03-08-01599.1983","volume":"3","author":"M DeLong","year":"1983","unstructured":"DeLong M, Crutcher M, Georgopoulos A (1983) Relations between movement and single cell discharge in the substantia nigra of the behaving monkey. J Neurosci 3(8):1599\u20131606","journal-title":"J Neurosci"},{"issue":"3","key":"931_CR6","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/0306-4522(96)00088-7","volume":"73","author":"J Deniau","year":"1996","unstructured":"Deniau J, Menetrey A, Charpier S (1996) The lamellar organization of the rat substantia nigra pars reticulata: segregated patterns of striatal afferents and relationship to the topography of corticostriatal projections. Neuroscience 73(3):761\u2013781","journal-title":"Neuroscience"},{"issue":"4","key":"931_CR7","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1002\/mds.25215","volume":"28","author":"D Dybdal","year":"2013","unstructured":"Dybdal D, Forcelli P, Dubach M et al (2013) Topography of dyskinesias and torticollis evoked by inhibition of substantia nigra pars reticulata. Mov Disord 28(4):460\u2013468","journal-title":"Mov Disord"},{"key":"931_CR8","first-page":"216","volume":"660","author":"A Faynveitz","year":"2019","unstructured":"Faynveitz A, Lavian H, Jacob A et al (2019) Proliferation of inhibitory input to the substantia nigra in experimental Parkinsonism. Front Cell Neurosci 660:216\u2013224","journal-title":"Front Cell Neurosci"},{"issue":"7879","key":"931_CR9","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41586-021-03993-3","volume":"598","author":"N Foster","year":"2021","unstructured":"Foster N, Barry J, Korobkova L et al (2021) The mouse cortico-basal ganglia-thalamic network. Nature 598(7879):188\u2013194","journal-title":"Nature"},{"key":"931_CR100","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/0014-4886(88)90031-3","volume":"100","author":"LM Gunne","year":"1988","unstructured":"Gunne LM, Bachus SE, Gale K et al (1988) Oral movements induced by interference with nigral GABA neurotransmission: relationship to tardive dyskinesias. Exp Neurol 100:459\u2013469","journal-title":"Exp Neurol"},{"key":"931_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/0006-8993(94)91292-0","volume":"660","author":"M Haj\u00f3s","year":"1994","unstructured":"Haj\u00f3s M, Greenfield S (1994) Synaptic connections between pars compacta and pars reticulata neurones: electrophysiological evidence for functional modules within the substantia nigra. Brain Res 660:216\u2013224","journal-title":"Brain Res"},{"issue":"4","key":"931_CR11","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1523\/JNEUROSCI.19-04-01446.1999","volume":"19","author":"J Hoover","year":"1999","unstructured":"Hoover J, Strick P (1999) The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. J Neurosci 19(4):1446\u20131463","journal-title":"J Neurosci"},{"issue":"2","key":"931_CR12","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuroscience.2005.03.040","volume":"134","author":"P Inchul","year":"2005","unstructured":"Inchul P, Amano A, Satoda T et al (2005) Control of oro-facio-lingual movements by the substantia nigra pars reticulata: high-frequency electrical microstimulation and gaba microinjection findings in rats. Neuroscience 134(2):677\u2013689","journal-title":"Neuroscience"},{"issue":"22","key":"931_CR13","doi-asserted-by":"publisher","first-page":"8509","DOI":"10.3390\/ijms21228509","volume":"21","author":"M Lagi\u00e8re","year":"2020","unstructured":"Lagi\u00e8re M, Bosc M, Whitestone S et al (2020) A subset of purposeless oral movements triggered by dopaminergic agonists is modulated by 5-HT2c receptors in rats: implication of the subthalamic nucleus. Int J Mol Sci 21(22):8509","journal-title":"Int J Mol Sci"},{"issue":"3","key":"931_CR14","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.nbd.2006.01.009","volume":"22","author":"W Meissner","year":"2006","unstructured":"Meissner W, Ravenscroft P, Reese R et al (2006) Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine. Neurobiol Dis 22(3):586\u2013598","journal-title":"Neurobiol Dis"},{"issue":"8","key":"931_CR15","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1046\/j.1460-9568.2002.02210.x","volume":"16","author":"M Meyer-Luehmann","year":"2002","unstructured":"Meyer-Luehmann M, Thompson J, Berridge K et al (2002) Substantia nigra pars reticulata neurons code initiation of a serial pattern: implications for natural action sequences and sequential disorders. Eur J Neurosci 16(8):1599\u20131608","journal-title":"Eur J Neurosci"},{"key":"931_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnana.2011.00051","volume":"5","author":"M Murer","year":"2011","unstructured":"Murer M, Moratalla R (2011) Striatal signaling in L-DOPA-induced dyskinesia: common mechanisms with drug abuse and long term memory involving d1 dopamine receptor stimulation. Front Neuroanat 5:51","journal-title":"Front Neuroanat"},{"issue":"4","key":"931_CR17","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1152\/jn.01036.2003","volume":"92","author":"A Nevet","year":"2004","unstructured":"Nevet A, Morris G, Saban G et al (2004) Discharge rate of substantia nigra pars reticulata neurons is reduced in non-parkinsonian monkeys with apomorphine-induced orofacial dyskinesia. J Neurophysiol 92(4):1973\u20131981","journal-title":"J Neurophysiol"},{"key":"931_CR18","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.pneurobio.2019.101678","volume":"182","author":"B Ribot","year":"2019","unstructured":"Ribot B, Aupy J, Vidailhet M et al (2019) Dystonia and dopamine: from phenomenology to pathophysiology. Prog Neurobiol 182:678","journal-title":"Prog Neurobiol"},{"issue":"1","key":"931_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1192\/bjp.bp.112.114538","volume":"203","author":"S Sarr\u00f3","year":"2013","unstructured":"Sarr\u00f3 S et al (2013) Structural brain changes associated with tardive dyskinesia in schizophrenia. Br J Psychiatry 203(1):51\u201357","journal-title":"Br J Psychiatry"},{"key":"931_CR20","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00429-016-1250-9","volume":"222","author":"S Shipp","year":"2017","unstructured":"Shipp S (2017) The functional logic of corticostriatal connections. Brain Struct Funct 222:669\u2013706","journal-title":"Brain Struct Funct"},{"key":"931_CR21","doi-asserted-by":"crossref","unstructured":"Simonyan K (2019) Recent advances in understanding the role of the basal ganglia [version 1; peer review: 2 approved]. F1000Res 8(F1000 Faculty Rev):122","DOI":"10.12688\/f1000research.16524.1"},{"issue":"2","key":"931_CR22","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1136\/jnnp.68.2.186","volume":"68","author":"E Tan","year":"2000","unstructured":"Tan E, Jankovic J (2000) Tardive and idiopathic oromandibular dystonia: a clinical comparison. J Neurol Neurosurg Psychiatry 68(2):186\u2013190","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"16","key":"931_CR23","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1002\/mds.22707","volume":"24","author":"D Tenback","year":"2009","unstructured":"Tenback D, vanHarten P, vanOs J (2009) Non-therapeutic risk factors for onset of tardive dyskinesia in schizophrenia: a meta-analysis. Mov Disord 24(16):2309\u20132315","journal-title":"Mov Disord"},{"key":"931_CR24","doi-asserted-by":"publisher","first-page":"135548","DOI":"10.1016\/j.neulet.2020.135548","volume":"742","author":"T Yu","year":"2021","unstructured":"Yu T, Li Y, Li N et al (2021) Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: a resting-state fMRI study. Neurosci Lett 742:135548","journal-title":"Neurosci Lett"}],"container-title":["Brain Topography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10548-022-00931-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10548-022-00931-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10548-022-00931-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,15]],"date-time":"2023-01-15T03:19:51Z","timestamp":1673752791000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10548-022-00931-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["931"],"URL":"https:\/\/doi.org\/10.1007\/s10548-022-00931-y","relation":{},"ISSN":["0896-0267","1573-6792"],"issn-type":[{"type":"print","value":"0896-0267"},{"type":"electronic","value":"1573-6792"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}