{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:27:33Z","timestamp":1792783653464,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"STI2030-Major Projects","award":["2022ZD0213300"],"award-info":[{"award-number":["2022ZD0213300"]}]},{"name":"Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning","award":["CNLZD2303"],"award-info":[{"award-number":["CNLZD2303"]}],"id":[{"id":"https:\/\/ror.org\/059y0zb32","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271953"],"award-info":[{"award-number":["82271953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Guangzhou Science and Technology Planning Project","award":["202103010001"],"award-info":[{"award-number":["202103010001"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2022-1-2031"],"award-info":[{"award-number":["2022-1-2031"]}]},{"name":"Beijing Natural Science Foundation","award":["L242029"],"award-info":[{"award-number":["L242029"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Topogr"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10548-025-01133-y","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T02:11:53Z","timestamp":1755483113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring Facial Nucleus-Centered Connectivity in Hemifacial Spasm: Novel Insights into Pathogenesis and Surgical Impact"],"prefix":"10.1007","volume":"38","author":[{"given":"Yu","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixin","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"issue":"1","key":"1133_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s13760-023-02342-7","volume":"124","author":"D Aktan","year":"2024","unstructured":"Aktan D, Depierreux F (2024) How to face the hemifacial spasm: challenges and misconceptions. Acta Neurol Belg 124(1):17\u201323. https:\/\/doi.org\/10.1007\/s13760-023-02342-7","journal-title":"Acta Neurol Belg"},{"key":"1133_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neuroscience.2014.12.070","volume":"289","author":"F Bao","year":"2015","unstructured":"Bao F, Wang Y, Liu J, Mao C, Ma S, Guo C, Zhang M (2015) Structural changes in the CNS of patients with hemifacial spasm. Neuroscience 289:56\u201362. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.12.070","journal-title":"Neuroscience"},{"issue":"1\u20132","key":"1133_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jns.2015.06.032","volume":"356","author":"N Chaudhry","year":"2015","unstructured":"Chaudhry N, Srivastava A, Joshi L (2015) Hemifacial spasm: the past, present and future. J Neurol Sci 356(1\u20132):27\u201331. https:\/\/doi.org\/10.1016\/j.jns.2015.06.032","journal-title":"J Neurol Sci"},{"key":"1133_CR4","doi-asserted-by":"crossref","unstructured":"Chen M, Ye M, Zhou W, Li S (2019) Preliminary Study on the Relationship Between Inflammation and Hemifacial Spasm. World Neurosurgery","DOI":"10.1016\/j.wneu.2019.01.044"},{"issue":"5","key":"1133_CR5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1097\/00002826-198610000-00002","volume":"9","author":"DA Cohen","year":"1986","unstructured":"Cohen DA, Savino PJ, Stern MB, Hurtig HI (1986) Botulinum injection therapy for blepharospasm. Clin Neuropharmacol 9(5):415\u2013429. https:\/\/doi.org\/10.1097\/00002826-198610000-00002","journal-title":"Clin Neuropharmacol"},{"key":"1133_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14396","author":"AC Engstrom","year":"2024","unstructured":"Engstrom AC, Alitin JPM, Kapoor A, Dutt S, Lohman T, Sible IJ, Nation DA (2024) Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits. Alzheimers Dement. https:\/\/doi.org\/10.1002\/alz.14396","journal-title":"Alzheimers Dement"},{"key":"1133_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2021.770107","author":"W Gao","year":"2021","unstructured":"Gao W, Yang D, Zhang Z, Du L, Liu B, Liu J, Ma G (2021) Altered cortical-striatal network in patients with hemifacial spasm. Front Hum Neurosci. https:\/\/doi.org\/10.3389\/fnhum.2021.770107","journal-title":"Front Hum Neurosci"},{"issue":"10","key":"1133_CR8","first-page":"19","volume":"22","author":"L Han-feng","year":"2024","unstructured":"Han-feng* L (2024) Meta-analysis of brain regions with functional and structural abnormalities in hemifacial spasm based on ALE. Chin J CT MRI 22(10):19\u201322","journal-title":"Chin J CT MRI"},{"key":"1133_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02840-9","author":"B Hartmannsberger","year":"2024","unstructured":"Hartmannsberger B, Ben-Kraiem A, Kramer S, Guidolin C, Kazerani I, Doppler K, Rittner HL (2024) TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury. Acta Neuropathol. https:\/\/doi.org\/10.1007\/s00401-024-02840-9","journal-title":"Acta Neuropathol"},{"key":"1133_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103380","volume":"38","author":"C Jung","year":"2023","unstructured":"Jung C, Kim J, Choi S, Seo YK, Park K-S, Choi Y, Kim H (2023) Attenuated facial movement in depressed women is associated with symptom severity, and nucleus accumbens functional connectivity. NeuroImage: Clinical 38:103380. https:\/\/doi.org\/10.1016\/j.nicl.2023.103380","journal-title":"NeuroImage: Clinical"},{"issue":"1","key":"1133_CR11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3171\/2023.5.jns221898","volume":"140","author":"AM Kaufmann","year":"2024","unstructured":"Kaufmann AM (2024) Hemifacial spasm: a neurosurgical perspective. J Neurosurg 140(1):240\u2013247. https:\/\/doi.org\/10.3171\/2023.5.jns221898","journal-title":"J Neurosurg"},{"issue":"7","key":"1133_CR12","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1007\/s10072-024-07353-7","volume":"45","author":"Z Li","year":"2024","unstructured":"Li Z, Xiong F, Gao F, Yu B, Tu Y (2024) Cortical changes in the brain of patients with hemifacial spasm. Neurol Sci 45(7):3209\u20133215. https:\/\/doi.org\/10.1007\/s10072-024-07353-7","journal-title":"Neurol Sci"},{"issue":"12","key":"1133_CR13","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1093\/brain\/awad328","volume":"146","author":"A Lischka","year":"2023","unstructured":"Lischka A, Eggermann K, Record C, Dohrn M, La\u0161\u0161uthov\u00e1 P, Kraft F, Kurth I (2023) Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies. Brain 146(12):4880\u20134890. https:\/\/doi.org\/10.1093\/brain\/awad328","journal-title":"Brain"},{"issue":"1","key":"1133_CR14","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1146\/annurev-vision-120222-014200","volume":"9","author":"CB Martin","year":"2023","unstructured":"Martin CB, Barense MD (2023) Perception and memory in the ventral visual stream and medial temporal lobe. Annu Rev Vis Sci 9(1):409\u2013434. https:\/\/doi.org\/10.1146\/annurev-vision-120222-014200","journal-title":"Annu Rev Vis Sci"},{"key":"1133_CR15","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190887","author":"X Niu","year":"2020","unstructured":"Niu X, Xu H, Guo C, Yang T, Kress D, Gao L, Wang Y (2020) Strengthened thalamoparietal functional connectivity in patients with hemifacial spasm: a cross-sectional resting-state fMRI study. Br J Radiol. https:\/\/doi.org\/10.1259\/bjr.20190887","journal-title":"Br J Radiol"},{"issue":"12","key":"1133_CR16","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1007\/s00702-023-02725-3","volume":"131","author":"J Rodr\u00edguez-Antig\u00fcedad","year":"2024","unstructured":"Rodr\u00edguez-Antig\u00fcedad J, Mart\u00ednez-Horta S, Horta-Barba A, Puig-Davi A, Campolongo A, Sampedro F, Kulisevsky J (2024) Facial emotion recognition deficits are associated with hypomimia and related brain correlates in Parkinson\u2019s disease. J Neural Transm 131(12):1463\u20131469. https:\/\/doi.org\/10.1007\/s00702-023-02725-3","journal-title":"J Neural Transm"},{"issue":"8","key":"1133_CR17","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1002\/hbm.26262","volume":"44","author":"W Sato","year":"2023","unstructured":"Sato W, Kochiyama T, Yoshikawa S (2023) The widespread action observation\/execution matching system for facial expression processing. Hum Brain Mapp 44(8):3057\u20133071. https:\/\/doi.org\/10.1002\/hbm.26262","journal-title":"Hum Brain Mapp"},{"key":"1133_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02854-5","author":"GJ Schnellb\u00e4cher","year":"2024","unstructured":"Schnellb\u00e4cher GJ, Rajkumar R, Veselinovi\u0107 T, Ramkiran S, Hagen J, Collee M, Neuner I (2024) Structural alterations as a predictor of depression \u2013 a 7-Tesla MRI-based multidimensional approach. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-024-02854-5","journal-title":"Mol Psychiatry"},{"key":"1133_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.923089","author":"B Szmyd","year":"2022","unstructured":"Szmyd B, So\u0142ek J, B\u0142aszczyk M, Jankowski J, Liberski Pawe\u0142P, Jask\u00f3lski DJ, Radek M (2022) The underlying pathogenesis of neurovascular compression syndromes: a systematic review. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2022.923089","journal-title":"Front Mol Neurosci"},{"issue":"9","key":"1133_CR20","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1007\/s10072-019-03921-4","volume":"40","author":"N Tambasco","year":"2019","unstructured":"Tambasco N, Simoni S, Sacchini E, Eusebi P, Marsili E, Nigro P, Calabresi P (2019) Validation of the hemifacial spasm grading scale: a clinical tool for hemifacial spasm. Neurol Sci 40(9):1887\u20131892. https:\/\/doi.org\/10.1007\/s10072-019-03921-4","journal-title":"Neurol Sci"},{"issue":"1","key":"1133_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1600-0404.2006.00650.x","volume":"114","author":"EK Tan","year":"2006","unstructured":"Tan EK, Chan LL (2006) Young onset hemifacial spasm. Acta Neurol Scand 114(1):59\u201362. https:\/\/doi.org\/10.1111\/j.1600-0404.2006.00650.x","journal-title":"Acta Neurol Scand"},{"issue":"4","key":"1133_CR22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.parkreldis.2004.12.003","volume":"11","author":"E-K Tan","year":"2005","unstructured":"Tan E-K, Lum S-Y, Fook-Chong S, Chan L-L, Gabriel C, Lim L (2005) Behind the facial twitch: depressive symptoms in hemifacial spasm. Parkinsonism Relat Disord 11(4):241\u2013245. https:\/\/doi.org\/10.1016\/j.parkreldis.2004.12.003","journal-title":"Parkinsonism Relat Disord"},{"issue":"4","key":"1133_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s10143-016-0729-4","volume":"39","author":"S Terasaka","year":"2016","unstructured":"Terasaka S, Asaoka K, Yamaguchi S, Kobayashi H, Motegi H, Houkin K (2016) A significant correlation between delayed cure after microvascular decompression and positive response to preoperative anticonvulsant therapy in patients with hemifacial spasm. Neurosurg Rev 39(4):607\u2013613. https:\/\/doi.org\/10.1007\/s10143-016-0729-4","journal-title":"Neurosurg Rev"},{"issue":"1","key":"1133_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116849","volume":"10","author":"Y Tu","year":"2015","unstructured":"Tu Y, Wei Y, Sun K, Zhao W, Yu B (2015) Altered spontaneous brain activity in patients with hemifacial spasm: a resting-state functional MRI study. PLoS One 10(1):e0116849. https:\/\/doi.org\/10.1371\/journal.pone.0116849","journal-title":"PLoS One"},{"issue":"2","key":"1133_CR25","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1016\/j.clinph.2015.07.036","volume":"127","author":"Y Tu","year":"2016","unstructured":"Tu Y, Yu T, Wei Y, Sun K, Zhao W, Yu B (2016) Structural brain alterations in hemifacial spasm: a voxel-based morphometry and diffusion tensor imaging study. Clin Neurophysiol 127(2):1470\u20131474. https:\/\/doi.org\/10.1016\/j.clinph.2015.07.036","journal-title":"Clin Neurophysiol"},{"key":"1133_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53360-9","author":"N Vockert","year":"2024","unstructured":"Vockert N, Machts J, Kleineidam L, Nemali A, Incesoy EI, Bernal J (2024) Cognitive reserve against Alzheimer\u2019s pathology is linked to brain activity during memory formation. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-024-53360-9","journal-title":"Nat Commun"},{"issue":"6","key":"1133_CR27","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00702-021-02343-x","volume":"128","author":"B Wabbels","year":"2021","unstructured":"Wabbels B, Yaqubi A (2021) Validation of a new hemifacial spasm grading questionnaire (HFS score) assessing clinical and quality of life parameters. J Neural Transm 128(6):793\u2013802. https:\/\/doi.org\/10.1007\/s00702-021-02343-x","journal-title":"J Neural Transm"},{"key":"1133_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-024-03883-x","author":"B Wang","year":"2024","unstructured":"Wang B, Wei X, Qi H, Bao X, Hu M, Ma J (2024a) Efficacy and safety of botulinum neurotoxin in the treatment of hemifacial spasms: a systematic review and meta-analysis. BMC Neurol. https:\/\/doi.org\/10.1186\/s12883-024-03883-x","journal-title":"BMC Neurol"},{"key":"1133_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-024-01765-4","author":"X Wang","year":"2024","unstructured":"Wang X, Xia Y, Yan R, Sun H, Huang Y, Xia Q, Lu Q (2024b) Sex differences in anhedonia in bipolar depression: a resting-state fMRI study. Eur Arch Psychiatry Clin Neurosci. https:\/\/doi.org\/10.1007\/s00406-024-01765-4","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"2","key":"1133_CR30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3171\/2016.2.jns151384","volume":"126","author":"MF Wilkinson","year":"2017","unstructured":"Wilkinson MF, Chowdhury T, Mutch WA, Kaufmann AM (2017) Analysis of facial motor evoked potentials for assessing a central mechanism in hemifacial spasm. J Neurosurg 126(2):379\u2013385. https:\/\/doi.org\/10.3171\/2016.2.jns151384","journal-title":"J Neurosurg"},{"issue":"1","key":"1133_CR31","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/ca.23652","volume":"34","author":"SH Yang","year":"2021","unstructured":"Yang SH, Park H, Yoo DS, Joo W, Rhoton A (2021) Microsurgical anatomy of the facial nerve. Clin Anat 34(1):90\u2013102. https:\/\/doi.org\/10.1002\/ca.23652","journal-title":"Clin Anat"},{"key":"1133_CR32","doi-asserted-by":"publisher","unstructured":"Ye W (2015) Resting-state functional magnetic resonance imaging study of the pathogenesis of hemifacial spasm. Chin J Neurosurg 31(5). https:\/\/doi.org\/10.3760\/cma.j.issn.1001-2346.2015.05.013","DOI":"10.3760\/cma.j.issn.1001-2346.2015.05.013"},{"key":"1133_CR33","doi-asserted-by":"publisher","unstructured":"Zhimin Y (2021) Excitability of facial nerve motor nucleus in patients with hemifacial spasm. Chin J Neuromedicine 20(6). https:\/\/doi.org\/10.3760\/cma.j.cn115354-20201229-01008","DOI":"10.3760\/cma.j.cn115354-20201229-01008"}],"container-title":["Brain Topography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10548-025-01133-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10548-025-01133-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10548-025-01133-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:26:40Z","timestamp":1757492800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10548-025-01133-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1133"],"URL":"https:\/\/doi.org\/10.1007\/s10548-025-01133-y","relation":{},"ISSN":["0896-0267","1573-6792"],"issn-type":[{"value":"0896-0267","type":"print"},{"value":"1573-6792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]},"assertion":[{"value":"4 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare they have no financial interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the China-Japan Friendship Hospital (approval No.2022-KY-181).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}],"article-number":"58"}}