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In this pilot study, we evaluated whether a small, zero-contact 16-channel OPM array can capture movement-related beta-band modulation (event-related desynchronization\/synchronization; ERD\/ERS) in healthy participants and explored feasibility in a single patient with amyotrophic lateral sclerosis (ALS). MEG responses to visually cued active and passive finger movements were recorded in a magnetically shielded room with the OPM array and separately with 306-channel superconducting quantum interference device (SQUID). Time\u2013frequency analyses focused on beta-band activity across baseline, ERD, and ERS periods. In healthy participants, both OPM and SQUID successfully captured movement-related beta oscillations, with no significant differences between active and passive conditions or between measurement systems, based on non-parametric tests. In the ALS patient, movement-related responses were attenuated and more affected by artifacts in the OPM data compared with SQUID, limiting interpretability. Although movement artifacts were noted, the OPM system provided group-level results in healthy controls comparable to SQUID-based MEG, demonstrating its viability and potential for rapid, flexible deployment. These findings indicate that a compact zero-contact OPM array can reliably measure movement-related cortical beta activity and may offer a cost-effective alternative to cryogenic MEG systems. In ALS, however, the present results should be interpreted strictly as a feasibility demonstration, and larger patient cohorts will be required to establish reliability and clinical utility.<\/jats:p>","DOI":"10.1007\/s10548-025-01150-x","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T17:35:59Z","timestamp":1764610559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Movement Related Beta-Band Modulation with OPM-MEG: A Pilot Study"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-4743","authenticated-orcid":false,"given":"Tobias Sevelsted","family":"St\u00e6rmose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob Udby","family":"Blicher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarang S.","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"issue":"2","key":"1150_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.neurobiolaging.2012.04.015","volume":"34","author":"F Agosta","year":"2013","unstructured":"Agosta F, Canu E, Valsasina P, Riva N, Prelle A, Comi G, Filippi M (2013) Divergent brain network connectivity in amyotrophic lateral sclerosis. 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