{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:50:25Z","timestamp":1783633825217,"version":"3.55.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T00:00:00Z","timestamp":1130457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T00:00:00Z","timestamp":1130457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1007\/s10549-005-9017-7","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T10:45:45Z","timestamp":1130409945000},"page":"257-263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours"],"prefix":"10.1007","volume":"95","author":[{"given":"Jenita","family":"Rauta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma-Leena","family":"Alarmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivikki","family":"Kauraniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Karhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"Kuukasj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kallioniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,10,28]]},"reference":[{"key":"9017_CR1","doi-asserted-by":"publisher","first-page":"6048","DOI":"10.1073\/pnas.94.12.6048","volume":"94","author":"M Fiscella","year":"1997","unstructured":"Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O\u2019Connor PM, Appella E, 1997 Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner Proc Natl Acad Sci USA 94: 6048\u20136053","journal-title":"Proc Natl Acad Sci USA"},{"key":"9017_CR2","doi-asserted-by":"publisher","first-page":"6517","DOI":"10.1093\/emboj\/19.23.6517","volume":"19","author":"M Takekawa","year":"2000","unstructured":"Takekawa M, Adachi M, Nakahata A, Nakayama I, Itoh F, Tsukuda H, Taya Y, Imai K, 2000 p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation EMBO J 19: 6517\u20136526","journal-title":"EMBO J"},{"key":"9017_CR3","doi-asserted-by":"publisher","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","volume":"271","author":"JN Lavoie","year":"1996","unstructured":"Lavoie JN, L\u2019Allemain G, Brunet A, Muller R, Pouyssegur J, 1996 Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway J Biol Chem 271: 20608\u201320616","journal-title":"J Biol Chem"},{"key":"9017_CR4","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/35075107","volume":"411","author":"DV Bulavin","year":"2001","unstructured":"Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ Jr, 2001 Initiation of a G2\/M checkpoint after ultraviolet radiation requires p38 kinase Nature 411: 102\u2013107","journal-title":"Nature"},{"key":"9017_CR5","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/ng894","volume":"31","author":"DV Bulavin","year":"2002","unstructured":"Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ,Jr, Appella E, 2002 Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity Nat Genet 31: 210\u2013215","journal-title":"Nat Genet"},{"key":"9017_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/ng888","volume":"31","author":"J Li","year":"2002","unstructured":"Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S, 2002 Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23 Nat Genet 31: 133\u2013134","journal-title":"Nat Genet"},{"key":"9017_CR7","first-page":"1876","volume":"63","author":"F Saito-Ohara","year":"2003","unstructured":"Saito-Ohara F, Imoto I, Inoue J, Hosoi H, Nakagawara A, Sugimoto T, Inazawa J, 2003 PPM1D is a potential target for 17q gain in neuroblastoma Cancer Res 63: 1876\u20131883","journal-title":"Cancer Res"},{"key":"9017_CR8","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.4161\/cc.3.11.1241","volume":"3","author":"X Lu","year":"2004","unstructured":"Lu X, Nguyen TA, Appella E, Donehower LA, 2004 Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins Cell Cycle 3: 1363\u20131366","journal-title":"Cell Cycle"},{"key":"9017_CR9","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1128\/MCB.22.4.1094-1105.2002","volume":"22","author":"J Choi","year":"2002","unstructured":"Choi J, Nannenga B, Demidov ON, Bulavin DV, Cooney A, Brayton C, Zhang Y, Mbawuike IN, Bradley A, Appella E, Donehower LA, 2002 Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control Mol Cell Biol 22: 1094\u20131105","journal-title":"Mol Cell Biol"},{"key":"9017_CR10","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/ng1317","volume":"36","author":"DV Bulavin","year":"2004","unstructured":"Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW, Appella E, Fornace AJ Jr, 2004 Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(arf) pathway Nat Genet 36: 343\u2013350","journal-title":"Nat Genet"},{"key":"9017_CR11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9440(10)64158-2","volume":"161","author":"CL Andersen","year":"2002","unstructured":"Andersen CL, Monni O, Wagner U, Kononen J, Barlund M, Bucher C, Haas P, Nocito A, Bissig H, Sauter G, Kallioniemi A, 2002 High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays Am J Pathol 161: 73\u201379","journal-title":"Am J Pathol"},{"key":"9017_CR12","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1023\/A:1023081624133","volume":"78","author":"CS Sinclair","year":"2003","unstructured":"Sinclair CS, Rowley M, Naderi A, Couch FJ, 2003 The 17q23 amplicon and breast cancer Breast Cancer Res Treat 78: 313\u2013322","journal-title":"Breast Cancer Res Treat"},{"key":"9017_CR13","first-page":"1995","volume":"9","author":"A Hirasawa","year":"2003","unstructured":"Hirasawa A, Saito-Ohara F, Inoue J, Aoki D, Susumu N, Yokoyama T, Nozawa S, Inazawa J, Imoto I, 2003 Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets Clin Cancer Res 9: 1995\u20132004","journal-title":"Clin Cancer Res"},{"key":"9017_CR14","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nm0798-844","volume":"4","author":"J Kononen","year":"1998","unstructured":"Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP, 1998 Tissue microarrays for high-throughput molecular profiling of tumor specimens Nat Med 4: 844\u2013847","journal-title":"Nat Med"},{"key":"9017_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/1097-0320(20011001)45:2<83::AID-CYTO1149>3.0.CO;2-P","volume":"45","author":"CL Andersen","year":"2001","unstructured":"Andersen CL, Hostetter G, Grigoryan A, Sauter G, Kallioniemi A, 2001 Improved procedure for fluorescence in situ hybridization on tissue microarrays Cytometry 45: 83\u201386","journal-title":"Cytometry"},{"key":"9017_CR16","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.1073\/pnas.091582298","volume":"98","author":"O Monni","year":"2001","unstructured":"Monni O, Barlund M, Mousses S, Kononen J, Sauter G, Heiskanen M, Paavola P, Avela K, Chen Y, Bittner ML, Kallioniemi A, 2001 Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer Proc Natl Acad Sci USA 98: 5711\u20135716","journal-title":"Proc Natl Acad Sci USA"},{"key":"9017_CR17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1006\/scbi.1998.0083","volume":"9","author":"JS Ross","year":"1999","unstructured":"Ross JS, Fletcher JA, 1999 The HER-2\/neu oncogene: prognostic factor, predictive factor and target for therapy Semin Cancer Biol 9: 125\u2013138","journal-title":"Semin Cancer Biol"},{"key":"9017_CR18","first-page":"5340","volume":"60","author":"M B\u00e4rlund","year":"2000","unstructured":"B\u00e4rlund M, Monni O, Kononen J, Cornelison R, Torhorst J, Sauter G, Kallioniemi OP, Kallioniemi A, 2000 Multiple genes at 17q23 undergo amplification and overexpression in breast cancer Cancer Res 60: 5340\u20135344","journal-title":"Cancer Res"},{"key":"9017_CR19","first-page":"6240","volume":"62","author":"E Hyman","year":"2002","unstructured":"Hyman E, Kauraniemi P, Hautaniemi S, Wolf M, Mousses S, Rozenblum E, Ringner M, Sauter G, Monni O, Elkahloun A, Kallioniemi OP, Kallioniemi A, 2002 Impact of DNA amplification on gene expression patterns in breast cancer Cancer Res 62: 6240\u20136245","journal-title":"Cancer Res"},{"key":"9017_CR20","doi-asserted-by":"publisher","first-page":"6453","DOI":"10.1158\/0008-5472.CAN-04-0756","volume":"64","author":"B Orsetti","year":"2004","unstructured":"Orsetti B, Nugoli M, Cervera N, Lasorsa L, Chuchana P, Ursule L, Nguyen C, Redon R, du Manoir S, Rodriguez C, Theillet C, 2004 Genomic and expression profiling of chromosome 17 in breast cancer reveals complex patterns of alterations and novel candidate genes Cancer Res 64: 6453\u20136460","journal-title":"Cancer Res"},{"key":"9017_CR21","first-page":"8861","volume":"63","author":"K Rennstam","year":"2003","unstructured":"Rennstam K, Ahlstedt-Soini M, Baldetorp B, Bendahl PO, Borg A, Karhu R, Tanner M, Tirkkonen M, Isola J, 2003 Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridization. Cancer Res 63: 8861\u20138868","journal-title":"Cancer Res"},{"key":"9017_CR22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/humu.10174","volume":"21","author":"AL Borresen-Dale","year":"2003","unstructured":"Borresen-Dale AL, 2003 TP53 and breast cancer Hum Mutat 21: 292\u2013300","journal-title":"Hum Mutat"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-005-9017-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-005-9017-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-005-9017-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-005-9017-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:10:56Z","timestamp":1652487056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-005-9017-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,28]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["9017"],"URL":"https:\/\/doi.org\/10.1007\/s10549-005-9017-7","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,28]]},"assertion":[{"value":"21 June 2005","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2005","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}