{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:12:13Z","timestamp":1704877933030},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T00:00:00Z","timestamp":1161734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T00:00:00Z","timestamp":1161734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1007\/s10549-006-9358-x","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T17:09:12Z","timestamp":1161709752000},"page":"247-257","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Establishment, growth and in vivo differentiation of a new clonal human cell line, EM-G3, derived from breast cancer progenitors"],"prefix":"10.1007","volume":"103","author":[{"given":"Marketa","family":"Brozova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Kleibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Netikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sevcik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Scholzova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Brezinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Chaloupkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Vesely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Dundr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Zadinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luboslava","family":"Krasna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Matouskova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,10,25]]},"reference":[{"key":"9358_CR1","first-page":"1131","volume":"21","author":"EY Lasfargues","year":"1958","unstructured":"Lasfargues EY, Ozzello L (1958) Cultivation of human breast carcinomas. J Natl Cancer Inst 21:1131\u20131147","journal-title":"J Natl Cancer Inst"},{"key":"9358_CR2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1023\/B:BREA.0000014042.54925.cc","volume":"83","author":"M Lacroix","year":"2004","unstructured":"Lacroix M, Leclercq G (2004) Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res Treat 83:249\u2013289","journal-title":"Breast Cancer Res Treat"},{"key":"9358_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0165-4608(99)00158-2","volume":"117","author":"C Jones","year":"2000","unstructured":"Jones C, Payne J, Wells D, Delhanty JD, Lakhani SR, Kortenkamp A (2000) Comparative genomic hybridization reveals extensive variation among different MCF-7 cell stocks. Cancer Genet Cytogenet 117:153\u2013158","journal-title":"Cancer Genet Cytogenet"},{"key":"9358_CR4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0165-4608(99)00253-8","volume":"120","author":"CS Wang","year":"2000","unstructured":"Wang CS, Goulet F, Lavoie J, Drouin R, Auger F, Champetier S, Germain L, Tetu B (2000) Establishment and characterization of a new cell line derived from a human primary breast carcinoma. Cancer Genet Cytogenet 120:58\u201372","journal-title":"Cancer Genet Cytogenet"},{"key":"9358_CR5","volume-title":"Human cancer in primary culture, 1st edn","author":"MJ O\u2019Hare","year":"1991","unstructured":"O\u2019Hare MJ (1991) Breast cancer. In: Masters JRW (eds) Human cancer in primary culture, 1st edn. Kluwer Academic Publishers, Dordrecht"},{"key":"9358_CR6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1242\/jcs.94.3.403","volume":"94","author":"J Taylor-Papadimitriou","year":"1989","unstructured":"Taylor-Papadimitriou J, Stampfer M, Bartek J, Lewis A, Boshell M, Lane EB, Leigh IM (1989) Keratin expression in human mammary epithelial cells cultured from normal and malignant tissue: relation to in vivo phenotypes and influence of medium. J Cell Sci 94:403\u2013413","journal-title":"J Cell Sci"},{"key":"9358_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/dbio.1998.9133","volume":"206","author":"C Pechoux","year":"1999","unstructured":"Pechoux C, Gudjonsson T, Ronnov-Jessen L, Bissell MJ, Petersen OW (1999) Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev Biol 206:88\u201399","journal-title":"Dev Biol"},{"key":"9358_CR8","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.yexcr.2004.03.029","volume":"297","author":"H Clayton","year":"2004","unstructured":"Clayton H, Titley I, Vivanco M (2004) Growth and differentiation of progenitor\/stem cells derived from the human mammary gland. Exp Cell Res 297:444\u2013460","journal-title":"Exp Cell Res"},{"key":"9358_CR9","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/bcr459","volume":"4","author":"MA Deugnier","year":"2002","unstructured":"Deugnier MA, Teuliere J, Faraldo MM, Thiery JP, Glukhova MA (2002) The importance of being a myoepithelial cell. Breast Cancer Res 4:224\u2013230","journal-title":"Breast Cancer Res"},{"key":"9358_CR10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/01.LAB.0000017371.72714.C5","volume":"82","author":"W Bocker","year":"2002","unstructured":"Bocker W, Moll R, Poremba C, Holland R, Van Diest PJ, Dervan P, Burger H, Wai D, Ina DR, Brandt B, Herbst H, Schmidt A, Lerch MM, Buchwallow IB (2002) Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab Invest 82:737\u2013746","journal-title":"Lab Invest"},{"key":"9358_CR11","unstructured":"Birnbaum D, Bertucci F, Ginestier C, Tagett R, Jacquemier J, Charafe-Jauffret E: Basal and luminal breast cancers: basic or luminous? (review). Int J Oncol 25:249\u2013258"},{"key":"9358_CR12","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10911-005-2540-7","volume":"10","author":"J Stingl","year":"2005","unstructured":"Stingl J, Raouf A, Emerman JT, Eaves CJ (2005) Epithelial progenitors in the normal human mammary gland. J Mammary Gland Biol Neoplasia 10:49\u201359","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"9358_CR13","first-page":"89","volume":"62","author":"J DiRenzo","year":"2002","unstructured":"DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M (2002) Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res 62:89\u201398","journal-title":"Cancer Res"},{"key":"9358_CR14","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/bcr1041","volume":"7","author":"B Gusterson","year":"2005","unstructured":"Gusterson B, Ross D, Heath V, Stein T (2005) Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res 7:143\u2013148","journal-title":"Breast Cancer Res"},{"key":"9358_CR15","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1101\/gad.952602","volume":"16","author":"T Gudjonsson","year":"2002","unstructured":"Gudjonsson T, Villadsen R, Nielsen HL, Ronnov-Jessen L, Bissell MJ, Petersen OW (2002) Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev 16:693\u2013706","journal-title":"Genes Dev"},{"key":"9358_CR16","first-page":"231","volume":"55","author":"SR Wellings","year":"1975","unstructured":"Wellings SR, Jensen HM, Marcum RG (1975) An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J Natl Cancer Inst 55:231\u2013273","journal-title":"J Natl Cancer Inst"},{"issue":"Suppl 1","key":"9358_CR17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1046\/j.1365-2184.36.s.1.4.x","volume":"36","author":"OW Petersen","year":"2003","unstructured":"Petersen OW, Gudjonsson T, Villadsen R, Bissell MJ, Ronnov-Jessen L (2003) Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia. Cell Prolif 36(Suppl 1):33\u201344","journal-title":"Cell Prolif"},{"issue":"Suppl 1","key":"9358_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1046\/j.1365-2184.36.s.1.6.x","volume":"36","author":"G Dontu","year":"2003","unstructured":"Dontu G, Al Hajj M, Abdallah WM, Clarke MF, Wicha MS (2003) Stem cells in normal breast development and breast cancer. Cell Prolif 36(Suppl 1):59\u201372","journal-title":"Cell Prolif"},{"key":"9358_CR19","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1073\/pnas.0530291100","volume":"100","author":"M Al Hajj","year":"2003","unstructured":"Al Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100:3983\u20133988","journal-title":"Proc Natl Acad Sci USA"},{"key":"9358_CR20","doi-asserted-by":"publisher","first-page":"5506","DOI":"10.1158\/0008-5472.CAN-05-0626","volume":"65","author":"D Ponti","year":"2005","unstructured":"Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG (2005) Isolation and in vitro propagation of tumorigenic breast cancer cells with stem\/progenitor cell properties. Cancer Res 65:5506\u20135511","journal-title":"Cancer Res"},{"key":"9358_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1023\/A:1006409605067","volume":"60","author":"E Matouskova","year":"2000","unstructured":"Matouskova E, Dudorkinova D, Krasna L, Vesely P (2000) Temporal in vitro expansion of the luminal lineage of human mammary epithelial cells achieved with the 3T3 feeder layer technique. Breast Cancer Res Treat 60:241\u2013249","journal-title":"Breast Cancer Res Treat"},{"key":"9358_CR22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1023\/A:1014457731494","volume":"71","author":"L Krasna","year":"2002","unstructured":"Krasna L, Dudorkinova D, Vedralova J, Vesely P, Pokorna E, Kudlackova I, Chaloupkova A, Petruzelka L, Danes J, Matouskova E (2002) Large expansion of morphologically heterogeneous mammary epithelial cells, including the luminal phenotype, from human breast tumours. Breast Cancer Res Treat 71:219\u2013235","journal-title":"Breast Cancer Res Treat"},{"key":"9358_CR23","first-page":"319","volume":"50","author":"M Hermanova","year":"2003","unstructured":"Hermanova M, Lukas Z, Kroupova I, Kleibl Z, Novotny J, Nenutil R, Pazourkova M, Brazdil J, Kren L, Dite P (2003) Relationship between K-ras mutation and the expression of p21WAF1\/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma. Neoplasma 50:319\u2013325","journal-title":"Neoplasma"},{"key":"9358_CR24","unstructured":"Brezinova J, Zemanova Z, Ransdorfova S, Sindelarova L, Siskova M, Neuwirtova R, Cermak J, Michalova K Prognostic significance of del(20q) in patients with hematological malignancies. Cancer Genet Cytogenet 160:188\u2013192"},{"key":"9358_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10549-005-9048-0","volume":"96","author":"SY Li","year":"2006","unstructured":"Li SY, Rong M, Grieu F, Iacopetta B (2006) PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 96:91\u201395","journal-title":"Breast Cancer Res Treat"},{"key":"9358_CR26","doi-asserted-by":"crossref","unstructured":"Mayr D, Hirschmann A, Lohrs U, Diebold J (2006) KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants. Gynecol Oncol (in press)","DOI":"10.1016\/j.ygyno.2006.05.029"},{"key":"9358_CR27","doi-asserted-by":"publisher","first-page":"7678","DOI":"10.1158\/0008-5472.CAN-04-2933","volume":"64","author":"IG Campbell","year":"2004","unstructured":"Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA (2004) Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64:7678\u20137681","journal-title":"Cancer Res"},{"key":"9358_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10549-005-9048-0","volume":"96","author":"SY Li","year":"2006","unstructured":"Li SY, Rong M, Grieu F, Iacopetta B (2006) PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 96:91\u201395","journal-title":"Breast Cancer Res Treat"},{"key":"9358_CR29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0076-6879(05)07018-7","volume":"407","author":"R Wooster","year":"2005","unstructured":"Wooster R, Futreal AP, Stratton MR (2005) Sequencing Analysis of BRAF Mutations in Human Cancers. Methods Enzymol 407:218\u2013224","journal-title":"Methods Enzymol"},{"key":"9358_CR30","volume-title":"Essentials of stem cell biology, 1st edn","author":"T Tumbar","year":"2006","unstructured":"Tumbar T, Fuchs E (2006) Epithelial skin stemm cells. In: Lanza R, Gearhart J, Hogan B (eds) Essentials of stem cell biology, 1st edn. Elsevier, Amsterdam, Academic Press, New York"},{"key":"9358_CR31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/path.1647","volume":"204","author":"CL Clarke","year":"2004","unstructured":"Clarke CL, Sandle J, Parry SC, Reis-Filho JS, O\u2019Hare MJ, Lakhani SR (2004) Cytokeratin 5\/6 in normal human breast: lack of evidence for a stem cell phenotype. J Pathol 204:147\u2013152","journal-title":"J Pathol"},{"key":"9358_CR32","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/modpathol.3800456","volume":"18","author":"M Laakso","year":"2005","unstructured":"Laakso M, Loman N, Borg A, Isola J (2005) Cytokeratin 5\/14-positive breast cancer: true basal phenotype confined to BRCA1 tumors. Mod Pathol 18:1321\u20131328","journal-title":"Mod Pathol"},{"issue":"Suppl 1","key":"9358_CR33","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1046\/j.1365-2184.36.s.1.7.x","volume":"36","author":"W Boecker","year":"2003","unstructured":"Boecker W, Buerger H (2003) Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif 36(Suppl 1):73\u201384","journal-title":"Cell Prolif"},{"key":"9358_CR34","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1083\/jcb.200207138","volume":"159","author":"MA Deugnier","year":"2002","unstructured":"Deugnier MA, Faraldo MM, Janji B, Rousselle P, Thiery JP, Glukhova MA (2002) The EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties. J Cell Biol 159:453\u2013463","journal-title":"J Cell Biol"},{"key":"9358_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1023\/A:1018789527533","volume":"4","author":"EC Rosfjord","year":"1999","unstructured":"Rosfjord EC, Dickson RB (1999) Growth factors, apoptosis, and survival of mammary epithelial cells. J Mammary Gland Biol Neoplasia 4:229\u2013237","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"9358_CR36","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ijc.2910500323","volume":"50","author":"TM Paine","year":"1992","unstructured":"Paine TM, Soule HD, Pauley RJ, Dawson PJ (1992) Characterization of epithelial phenotypes in mortal and immortal human breast cells. Int J Cancer 50:463\u2013473","journal-title":"Int J Cancer"},{"key":"9358_CR37","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1038\/nrc1212","volume":"3","author":"M Smalley","year":"2003","unstructured":"Smalley M, Ashworth A (2003) Stem cells and breast cancer: a field in transit. Nat Rev Cancer 3:832\u2013844","journal-title":"Nat Rev Cancer"},{"key":"9358_CR38","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1126\/science.274.5295.2057","volume":"274","author":"G Deng","year":"1996","unstructured":"Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS (1996) Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 274:2057\u20132059","journal-title":"Science"},{"key":"9358_CR39","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<496::AID-PATH485>3.0.CO;2-D","volume":"189","author":"SR Lakhani","year":"1999","unstructured":"Lakhani SR, Chaggar R, Davies S, Jones C, Collins N, Odel C, Stratton MR, O\u2019Hare MJ (1999) Genetic alterations in \u2018normal\u2019 luminal and myoepithelial cells of the breast. J Pathol 189:496\u2013503","journal-title":"J Pathol"},{"key":"9358_CR40","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1126\/science.301.5638.1308","volume":"301","author":"J Marx","year":"2003","unstructured":"Marx J (2003) Cancer research. Mutant stem cells may seed cancer. Science 301:1308\u20131310","journal-title":"Science"},{"key":"9358_CR41","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105\u2013111","journal-title":"Nature"},{"key":"9358_CR42","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s10540-005-2797-5","volume":"24","author":"SL Wenger","year":"2004","unstructured":"Wenger SL, Senft JR, Sargent LM, Bamezai R, Bairwa N, Grant SG (2004) Comparison of established cell lines at different passages by karyotype and comparative genomic hybridization. Biosci Rep 24:631\u2013639","journal-title":"Biosci Rep"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-006-9358-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-006-9358-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-006-9358-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-006-9358-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T20:46:35Z","timestamp":1652820395000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-006-9358-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,25]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["9358"],"URL":"https:\/\/doi.org\/10.1007\/s10549-006-9358-x","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,25]]},"assertion":[{"value":"13 April 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}