{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:34:13Z","timestamp":1756895653381},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T00:00:00Z","timestamp":1159315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2007,6,20]]},"DOI":"10.1007\/s10549-006-9388-4","type":"journal-article","created":{"date-parts":[[2006,9,26]],"date-time":"2006-09-26T13:33:09Z","timestamp":1159277589000},"page":"57-66","source":"Crossref","is-referenced-by-count":6,"title":["A strong association between body fat mass and protein profiles in nipple aspirate fluid of healthy premenopausal non-lactating women"],"prefix":"10.1007","volume":"104","author":[{"given":"Yafei","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manubai","family":"Nagamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kurosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony M.","family":"Haag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Grady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee-Jane W.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"9388_CR1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF01805919","volume":"1","author":"NL Petrakis","year":"1986","unstructured":"Petrakis NL (1986) Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid. Breast Cancer Res Treat 1:7\u201319","journal-title":"Breast Cancer Res Treat"},{"key":"9388_CR2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1046\/j.1524-4741.2001.07601.x","volume":"6","author":"P Klein","year":"2001","unstructured":"Klein P, Glaser E, Grogan L, Keane M, Lipkowitz S, Soballe P, Brooks L, Jenkins J, Steinberg SM, DeMarini DM, Kirsch I (2001) Biomarker assays in nipple aspirate fluid. Breast J 6:378\u2013387","journal-title":"Breast J"},{"key":"9388_CR3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1075-122X.2005.21553.x","volume":"2","author":"Z Djuric","year":"2005","unstructured":"Djuric Z, Visscher DW, Heilbrun LK, Chen G, Atkins M, Covington CY (2005) Influence of lactation history on breast nipple aspirate fluid yields and fluid composition. Breast J 2:92\u201399","journal-title":"Breast J"},{"key":"9388_CR4","first-page":"33","volume":"1","author":"MM Lee","year":"1994","unstructured":"Lee MM, Petrakis NL, Wrensch MR, King EB, Miike R, Sickles E (1994) Association of abnormal nipple aspirate cytology and mammographic pattern and density. Cancer Epidemiol Biomarkers Prev 1:33\u201336","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9388_CR5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0361-090X(02)00028-4","volume":"2","author":"ER Sauter","year":"2002","unstructured":"Sauter ER, Chervoneva I, Diamandis A, Khosravi JM, Litwin S, Diamandis EP (2002) Prostate-specific antigen and insulin-like growth factor binding protein-3 in nipple aspirate fluid are associated with breast cancer. Cancer Detect Prev 2:149\u2013157","journal-title":"Cancer Detect Prev"},{"key":"9388_CR6","first-page":"95","volume":"1","author":"LM Sanchez","year":"1992","unstructured":"Sanchez LM, Vizoso F, Diez-Itza I, Lopez-Otin C (1992) Identification of the major protein components in breast secretions from women with benign and malignant breast diseases. Cancer Res 1:95\u2013100","journal-title":"Cancer Res"},{"key":"9388_CR7","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1002\/pmic.200401037","volume":"6","author":"S Hu","year":"2005","unstructured":"Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT (2005) Large-scale identification of proteins in human salivary proteome by liquid chromatography\/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics 6:1714\u20131728","journal-title":"Proteomics"},{"key":"9388_CR8","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1177\/39.9.1918940","volume":"9","author":"T Tada","year":"1991","unstructured":"Tada T, Ohkubo I, Niwa M, Sasaki M, Tateyama H, Eimoto T (1991) Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues. J Histochem Cytochem 9:1221\u20131226","journal-title":"J Histochem Cytochem"},{"key":"9388_CR9","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1042\/bst0310810","volume":"4","author":"B Ghafouri","year":"2003","unstructured":"Ghafouri B, Kihlstrom E, Stahlbom B, Tagesson C, Lindahl M (2003) PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid. Biochem Soc Trans Pt 4:810\u2013814","journal-title":"Biochem Soc Trans Pt"},{"key":"9388_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0277-5379(91)90213-W","volume":"5","author":"NJ Bundred","year":"1991","unstructured":"Bundred NJ, Scott WN, Davies SJ, Miller WR, Mansel RE (1991) Zinc alpha-2 glycoprotein levels in serum and breast fluids: a potential marker of apocrine activity. Eur J Cancer 5:549\u2013552","journal-title":"Eur J Cancer"},{"key":"9388_CR11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01831479","volume":"1\u20132","author":"DE Haagensen","year":"1992","unstructured":"Haagensen DE, Stewart P, Dilley WG, Wells SA (1992) Secretion of breast gross cystic disease fluid proteins by T47D breast cancer cells in culture\u2013modulation by steroid hormones. Breast Cancer Res Treat 1\u20132:77\u201386","journal-title":"Breast Cancer Res Treat"},{"key":"9388_CR12","first-page":"1115","volume":"3","author":"J Simard","year":"1992","unstructured":"Simard J, de Launoit Y, Haagensen DE, Labrie F (1992) Additive stimulatory action of glucocorticoids and androgens on basal and estrogen-repressed apolipoprotein-D messenger ribonucleic acid levels and secretion in human breast cancer cells. Endocrinology 3:1115\u20131121","journal-title":"Endocrinology"},{"key":"9388_CR13","first-page":"805","volume":"8","author":"C Boutteville","year":"1989","unstructured":"Boutteville C, Revillion F, Vandewalle B, Lefebvre J (1989) [Hormonal regulation of GCDFP-15 secretion in breast tumors. Study of cultured cells]. Bull Cancer 8:805\u2013811","journal-title":"Study of cultured cells]. Bull Cancer"},{"key":"9388_CR14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/mend-3-4-694","volume":"4","author":"J Simard","year":"1989","unstructured":"Simard J, Hatton AC, Labrie C, Dauvois S, Zhao HF, Haagensen DE, Labrie F (1989) Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75\u20131 human breast cancer cells. Mol Endocrinol 4:694\u2013702","journal-title":"Mol Endocrinol"},{"key":"9388_CR15","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1210\/endo-126-6-3223","volume":"6","author":"J Simard","year":"1990","unstructured":"Simard J, Dauvois S, Haagensen DE, Levesque C, Merand Y, Labrie F (1990) Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer. Endocrinology 6:3223\u20133231","journal-title":"Endocrinology"},{"key":"9388_CR16","doi-asserted-by":"crossref","first-page":"15236","DOI":"10.1016\/S0021-9258(18)48164-1","volume":"31","author":"LC Murphy","year":"1987","unstructured":"Murphy LC, Tsuyuki D, Myal Y, Shiu RP (1987) Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. J Biol Chem 31:15236\u201315241","journal-title":"J Biol Chem"},{"key":"9388_CR17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1096\/fj.99-0863com","volume":"12","author":"J Zhou","year":"2000","unstructured":"Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy CA (2000) Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J 12:1725\u20131730","journal-title":"FASEB J"},{"key":"9388_CR18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1152\/physrev.1980.60.4.1049","volume":"4","author":"YJ Topper","year":"1980","unstructured":"Topper YJ, Freeman CS (1980) Multiple hormone interactions in the developmental biology of the mammary gland. Physiol Rev 4:1049\u20131106","journal-title":"Physiol Rev"},{"key":"9388_CR19","first-page":"573","volume":"2","author":"DB Ray","year":"1981","unstructured":"Ray DB, Horst IA, Jansen RW, Kowal J (1981) Normal mammary cells in long term culture. I. development of hormone-dependent functional monolayer cultures and assay of alpha-lactalbumin production. Endocrinology 2:573\u2013583","journal-title":"Endocrinology"},{"key":"9388_CR20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1210\/endo-124-2-992","volume":"2","author":"CT Teng","year":"1989","unstructured":"Teng CT, Pentecost BT, Chen YH, Newbold RR, Eddy EM, McLachlan JA (1989) Lactotransferrin gene expression in the mouse uterus and mammary gland. Endocrinology 2:992\u2013999","journal-title":"Endocrinology"},{"key":"9388_CR21","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10434-001-0667-3","volume":"8","author":"F Vizoso","year":"2001","unstructured":"Vizoso F, Plaza E, Vazquez J, Serra C, Lamelas ML, Gonzalez LO, Merino AM, Mendez J (2001) Lysozyme expression by breast carcinomas, correlation with clinicopathologic parameters, and prognostic significance. Ann Surg Oncol 8:667\u2013674","journal-title":"Ann Surg Oncol"},{"key":"9388_CR22","doi-asserted-by":"crossref","unstructured":"Webster J, Oxley D (2005) Peptide mass fingerprinting: protein identification using MALDI-TOF mass spectrometry. Methods Mol Biol 227\u2013240","DOI":"10.1007\/978-1-59259-948-6_16"},{"key":"9388_CR23","first-page":"43","volume":"1","author":"DP Rose","year":"1992","unstructured":"Rose DP (1992) Hormones and growth factors in nipple aspirates from normal women and benign breast disease patients. Cancer Detect Prev 1:43\u201351","journal-title":"Cancer Detect Prev"},{"key":"9388_CR24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF01833522","volume":"3","author":"F Vizoso","year":"1992","unstructured":"Vizoso F, Sanchez LM, Diez-Itza I, Luz LM, Lopez-Otin C (1992) Factors affecting protein composition of breast secretions from nonlactating women. Breast Cancer Res Treat 3:251\u2013258","journal-title":"Breast Cancer Res Treat"},{"key":"9388_CR25","first-page":"525","volume":"2","author":"F Vizoso","year":"1994","unstructured":"Vizoso F, Diez-Itza I, Sanchez LM, Tuya AF, Ruibal A, Lopez-Otin C (1994) Relationship between serum prolactin levels and protein composition of breast secretions in nonlactating women. J Clin Endocrinol Metab 2:525\u2013529","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl","key":"9388_CR26","doi-asserted-by":"crossref","first-page":"3451S","DOI":"10.1093\/jn\/132.11.3451S","volume":"11","author":"GA Bray","year":"2002","unstructured":"Bray GA (2002) The underlying basis for obesity: relationship to cancer. J Nutr 11(Suppl):3451S\u20133455S","journal-title":"J Nutr"},{"key":"9388_CR27","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1210\/jc.2004-0535","volume":"6","author":"GA Bray","year":"2004","unstructured":"Bray GA (2004) Medical consequences of obesity. J Clin Endocrinol Metab 6:2583\u20132589","journal-title":"J Clin Endocrinol Metab"},{"key":"9388_CR28","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1158\/1055-9965.EPI-05-0185","volume":"12","author":"ML Irwin","year":"2005","unstructured":"Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R (2005) Relationship of obesity and physical activity with C-peptide, leptin, and insulin-like growth factors in breast cancer survivors. Cancer Epidemiol Biomarkers Prev 12:2881\u20132888","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9388_CR29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.1.05762","volume":"2","author":"M Quinkler","year":"2004","unstructured":"Quinkler M, Sinha B, Tomlinson JW, Bujalska IJ, Stewart PM, Arlt W (2004) Androgen generation in adipose tissue in women with simple obesity\u2013a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5. J Endocrinol 2:331\u2013342","journal-title":"J Endocrinol"},{"key":"9388_CR30","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1096\/fj.00-0530fje","volume":"7","author":"Z Liu","year":"2001","unstructured":"Liu Z, Chang GQ, Leibowitz SF (2001) Apolipoprotein D interacts with the long-form leptin receptor: a hypothalamic function in the control of energy homeostasis. FASEB J 7:1329\u20131331","journal-title":"FASEB J"},{"key":"9388_CR31","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1073\/pnas.0308647100","volume":"8","author":"C Bing","year":"2004","unstructured":"Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ, Trayhurn P (2004) Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci U S A 8:2500\u20132505","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9388_CR32","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.2337\/diabetes.52.8.2175","volume":"8","author":"T Gohda","year":"2003","unstructured":"Gohda T, Makita Y, Shike T, Tanimoto M, Funabiki K, Horikoshi S, Tomino Y (2003) Identification of epistatic interaction involved in obesity using the KK\/Ta mouse as a Type 2 diabetes model: is Zn-alpha2 glycoprotein-1 a candidate gene for obesity? Diabetes 8:2175\u20132181","journal-title":"Diabetes"},{"key":"9388_CR33","first-page":"141","volume":"3","author":"A Manni","year":"1984","unstructured":"Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Drago J, Rohner T, Haagensen D, Glode M, Santner SJ (1984) Evaluation of CEA and GCDFP-15 plasma level during hormonally induced cancer stimulation. Anticancer Res 3:141\u2013144","journal-title":"Anticancer Res"},{"key":"9388_CR34","doi-asserted-by":"crossref","unstructured":"Haagensen DE, Jr., Dilley WG, Mazoujian G, Wells SA, Jr (1990) Review of GCDFP-15. An apocrine marker protein. Ann N Y Acad Sci 161\u2013173","DOI":"10.1111\/j.1749-6632.1990.tb17804.x"},{"key":"9388_CR35","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1158\/1078-0432.CCR-04-1002","volume":"22","author":"H Alexander","year":"2004","unstructured":"Alexander H, Stegner AL, Wagner-Mann C, Du Bois GC, Alexander S, Sauter ER (2004) Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid. Clin Cancer Res 22:7500\u20137510","journal-title":"Clin Cancer Res"},{"key":"9388_CR36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF01811888","volume":"1","author":"MR Wrensch","year":"1990","unstructured":"Wrensch MR, Petrakis NL, Gruenke LD, Ernster VL, Miike R, King EB, Hauck WW (1990) Factors associated with obtaining nipple aspirate fluid: analysis of 1428 women and literature review. Breast Cancer Res Treat 1:39\u201351","journal-title":"Breast Cancer Res Treat"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-006-9388-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-006-9388-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-006-9388-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T15:31:57Z","timestamp":1627831917000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-006-9388-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,6,20]]}},"alternative-id":["9388"],"URL":"https:\/\/doi.org\/10.1007\/s10549-006-9388-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}