{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:08:20Z","timestamp":1759939700133},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1007\/s10549-008-0284-y","type":"journal-article","created":{"date-parts":[[2009,1,12]],"date-time":"2009-01-12T14:26:43Z","timestamp":1231770403000},"page":"521-527","source":"Crossref","is-referenced-by-count":7,"title":["The addition of hormone therapy to tamoxifen does not prevent hot flashes in women at high risk for developing breast cancer"],"prefix":"10.1007","volume":"116","author":[{"given":"Cynthia R.","family":"Osborne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scot","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devchand","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frankie","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetislava","family":"Vukelja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Wilks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"McGee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wally G.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce A.","family":"O\u2019Shaughnessy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"284_CR1","doi-asserted-by":"crossref","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet 351(9114):1451\u20131467. doi: 10.1016\/S0140-6736(97)11423-4","DOI":"10.1016\/S0140-6736(97)11423-4"},{"issue":"21","key":"284_CR2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1093\/jnci\/88.21.1529","volume":"88","author":"B Fisher","year":"1996","unstructured":"Fisher B et al (1996) Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst 88(21):1529\u20131542. doi: 10.1093\/jnci\/88.21.1529","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"284_CR3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/jnci\/djk050","volume":"99","author":"TJ Powles","year":"2007","unstructured":"Powles TJ et al (2007) Twenty-year follow-up of the Royal Marsden randomized, double-blinded tamoxifen breast cancer prevention trial. J Natl Cancer Inst 99(4):283\u2013290. doi: 10.1093\/jnci\/djk050","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"284_CR4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1093\/jnci\/djk049","volume":"99","author":"J Cuzick","year":"2007","unstructured":"Cuzick J et al (2007) Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial. J Natl Cancer Inst 99(4):272\u2013282. doi: 10.1093\/jnci\/djk049","journal-title":"J Natl Cancer Inst"},{"issue":"22","key":"284_CR5","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1093\/jnci\/dji372","volume":"97","author":"B Fisher","year":"2005","unstructured":"Fisher B et al (2005) Tamoxifen for the prevention of breast cancer: current status of the national surgical adjuvant breast and bowel project P-1 study. J Natl Cancer Inst 97(22):1652\u20131662","journal-title":"J Natl Cancer Inst"},{"issue":"9122","key":"284_CR6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0140-6736(98)85011-3","volume":"352","author":"U Veronesi","year":"1998","unstructured":"Veronesi U et al (1998) Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Italian tamoxifen prevention study. Lancet 352(9122):93\u201397. doi: 10.1016\/S0140-6736(98)85011-3","journal-title":"Lancet"},{"issue":"24","key":"284_CR7","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/jnci\/81.24.1879","volume":"81","author":"MH Gail","year":"1989","unstructured":"Gail MH et al (1989) Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 81(24):1879\u20131886. doi: 10.1093\/jnci\/81.24.1879","journal-title":"J Natl Cancer Inst"},{"issue":"18","key":"284_CR8","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","volume":"90","author":"B Fisher","year":"1998","unstructured":"Fisher B et al (1998) Tamoxifen for prevention of breast cancer: report of the national surgical adjuvant breast and bowel project P-1 Study. J Natl Cancer Inst 90(18):1371\u20131388. doi: 10.1093\/jnci\/90.18.1371","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"284_CR9","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1200\/JCO.1999.17.9.2659","volume":"17","author":"R Day","year":"1999","unstructured":"Day R et al (1999) Health-related quality of life and tamoxifen in breast cancer prevention: a report from the national surgical adjuvant breast and bowel project P-1 study. J Clin Oncol 17(9):2659\u20132669","journal-title":"J Clin Oncol"},{"issue":"9122","key":"284_CR10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0140-6736(98)85012-5","volume":"352","author":"T Powles","year":"1998","unstructured":"Powles T et al (1998) Interim analysis of the incidence of breast cancer in the royal Marsden hospital tamoxifen randomised chemoprevention trial. Lancet 352(9122):98\u2013101. doi: 10.1016\/S0140-6736(98)85012-5","journal-title":"Lancet"},{"issue":"7","key":"284_CR11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/oxfordjournals.annonc.a010715","volume":"7","author":"J Chang","year":"1996","unstructured":"Chang J et al (1996) The effect of tamoxifen and hormone replacement therapy on serum cholesterol, bone mineral density and coagulation factors in healthy postmenopausal women participating in a randomised, controlled tamoxifen prevention study. Ann Oncol 7(7):671\u2013675","journal-title":"Ann Oncol"},{"issue":"7","key":"284_CR12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10434-001-0580-9","volume":"8","author":"ER Port","year":"2001","unstructured":"Port ER et al (2001) Patient reluctance toward tamoxifen use for breast cancer primary prevention. Ann Surg Oncol 8(7):580\u2013585. doi: 10.1007\/s10434-001-0580-9","journal-title":"Ann Surg Oncol"},{"key":"284_CR13","unstructured":"NIH (2005) NIH state-of-the-science conference statement on management of menopause-related symptoms. NIH Consens State Sci Statements 22(1):1\u201338"},{"issue":"4","key":"284_CR14","first-page":"CD002978","volume":"18","author":"AH Maclennan","year":"2004","unstructured":"Maclennan AH et al (2004) Oral oestrogen and combined oestrogen\/progestogen therapy versus placebo for hot flushes. Cochrane Database Syst Rev 18(4):CD002978","journal-title":"Cochrane Database Syst Rev"},{"issue":"24","key":"284_CR15","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1200\/JCO.2005.04.3745","volume":"24","author":"I Sestak","year":"2006","unstructured":"Sestak I et al (2006) Influence of hormone replacement therapy on tamoxifen-induced vasomotor symptoms. J Clin Oncol 24(24):3991\u20133996. doi: 10.1200\/JCO.2005.04.3745","journal-title":"J Clin Oncol"},{"issue":"2","key":"284_CR16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1075-122X.2006.00218.x","volume":"12","author":"GG Kimmick","year":"2006","unstructured":"Kimmick GG et al (2006) Randomized, double-blind, placebo-controlled, crossover study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen. Breast J 12(2):114\u2013122. doi: 10.1111\/j.1075-122X.2006.00218.x","journal-title":"Breast J"},{"issue":"9247","key":"284_CR17","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(00)03403-6","volume":"356","author":"CL Loprinzi","year":"2000","unstructured":"Loprinzi CL et al (2000) Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet 356(9247):2059\u20132063. doi: 10.1016\/S0140-6736(00)03403-6","journal-title":"Lancet"},{"issue":"6","key":"284_CR18","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1200\/JCO.2002.20.6.1578","volume":"20","author":"CL Loprinzi","year":"2002","unstructured":"Loprinzi CL et al (2002) Phase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol 20(6):1578\u20131583. doi: 10.1200\/JCO.20.6.1578","journal-title":"J Clin Oncol"},{"issue":"1","key":"284_CR19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clpt.2006.03.013","volume":"80","author":"S Borges","year":"2006","unstructured":"Borges S et al (2006) Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80(1):61\u201374. doi: 10.1016\/j.clpt.2006.03.013","journal-title":"Clin Pharmacol Ther"},{"issue":"7","key":"284_CR20","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1200\/JCO.2005.01.079","volume":"23","author":"CH Kroenke","year":"2005","unstructured":"Kroenke CH et al (2005) Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol 23(7):1370\u20131378. doi: 10.1200\/JCO.2005.01.079","journal-title":"J Clin Oncol"},{"issue":"17","key":"284_CR21","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jama.1997.03550170037029","volume":"278","author":"Z Huang","year":"1997","unstructured":"Huang Z et al (1997) Dual effects of weight and weight gain on breast cancer risk. JAMA 278(17):1407\u20131411. doi: 10.1001\/jama.278.17.1407","journal-title":"JAMA"},{"issue":"1","key":"284_CR22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1200\/JCO.2002.20.1.42","volume":"20","author":"PJ Goodwin","year":"2002","unstructured":"Goodwin PJ et al (2002) Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 20(1):42\u201351. doi: 10.1200\/JCO.20.1.42","journal-title":"J Clin Oncol"},{"issue":"4","key":"284_CR23","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1200\/JCO.2002.20.4.1128","volume":"20","author":"RT Chlebowski","year":"2002","unstructured":"Chlebowski RT, Aiello E, McTiernan A (2002) Weight loss in breast cancer patient management. J Clin Oncol 20(4):1128\u20131143. doi: 10.1200\/JCO.20.4.1128","journal-title":"J Clin Oncol"},{"issue":"20","key":"284_CR24","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","volume":"289","author":"SA Shumaker","year":"2003","unstructured":"Shumaker SA et al (2003) Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women\u2019s Health Initiative Memory Study: a randomized controlled trial. JAMA 289(20):2651\u20132662. doi: 10.1001\/jama.289.20.2651","journal-title":"JAMA"},{"issue":"24","key":"284_CR25","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1001\/jama.291.24.2947","volume":"291","author":"SA Shumaker","year":"2004","unstructured":"Shumaker SA et al (2004) Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women\u2019s Health Initiative Memory Study. JAMA 291(24):2947\u20132958. doi: 10.1001\/jama.291.24.2947","journal-title":"JAMA"},{"issue":"20","key":"284_CR26","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.289.20.2673","volume":"289","author":"S Wassertheil-Smoller","year":"2003","unstructured":"Wassertheil-Smoller S et al (2003) Effect of estrogen plus progestin on stroke in postmenopausal women: the Women\u2019s Health Initiative: a randomized trial. JAMA 289(20):2673\u20132684. doi: 10.1001\/jama.289.20.2673","journal-title":"JAMA"},{"issue":"14","key":"284_CR27","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1775","volume":"291","author":"GL Anderson","year":"2004","unstructured":"Anderson GL et al (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women\u2019s Health Initiative randomized controlled trial. JAMA 291(14):1701\u20131712. doi: 10.1001\/jama.291.14.1775","journal-title":"JAMA"},{"issue":"3","key":"284_CR28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"JE Rossouw","year":"2002","unstructured":"Rossouw JE et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women\u2019s Health Initiative randomized controlled trial. JAMA 288(3):321\u2013333. doi: 10.1001\/jama.288.3.321","journal-title":"JAMA"},{"issue":"23","key":"284_CR29","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1200\/JCO.2001.19.23.4280","volume":"19","author":"JA Sloan","year":"2001","unstructured":"Sloan JA et al (2001) Methodologic lessons learned from hot flash studies. J Clin Oncol 19(23):4280\u20134290","journal-title":"J Clin Oncol"},{"issue":"10","key":"284_CR30","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2387::AID-CNCR25>3.0.CO;2-P","volume":"88","author":"E Maunsell","year":"2000","unstructured":"Maunsell E et al (2000) A brief pain diary for ambulatory patients with advanced cancer: acceptability and validity. Cancer 88(10):2387\u20132397. doi:10.1002\/(SICI)1097-0142(20000515)88:10<2387::AID-CNCR25>3.0.CO;2-P","journal-title":"Cancer"},{"key":"284_CR31","unstructured":"Duncan AJ, Sedlacek SM, Holmes FA, Vukelja SJ, Wilkes ST, O\u2019Shaughnessy JA (2002) No difference in menopausal symptoms and severity of hot flashes comparing combined hormone replacement therapy plus tamoxifen to tamoxifen alone in peri- or post-menopausal women at high risk for developing breast cancer. In 25th annual San Antonio breast cancer symposium. Kluwer, San Antonio"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-008-0284-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-008-0284-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-008-0284-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T16:29:04Z","timestamp":1559233744000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-008-0284-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,13]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["284"],"URL":"https:\/\/doi.org\/10.1007\/s10549-008-0284-y","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,13]]}}}