{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:07:07Z","timestamp":1790863627000,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1007\/s10549-009-0715-4","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T03:45:33Z","timestamp":1263181533000},"page":"121-131","source":"Crossref","is-referenced-by-count":22,"title":["Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells"],"prefix":"10.1007","volume":"124","author":[{"given":"Scott R.","family":"Burks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana F.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene D.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine H.","family":"Tkaczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart S.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald M.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Halpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Brodie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P. Y.","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,12]]},"reference":[{"key":"715_CR1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/CCO.0b013e3282f0ad79","volume":"19","author":"C Alix-Panabieres","year":"2007","unstructured":"Alix-Panabieres C, Muller V, Pantel K (2007) Current status in human breast cancer micrometastasis. Curr Opin Oncol 19:558\u2013563. doi: 10.1097\/CCO.0b013e3282f0ad79","journal-title":"Curr Opin Oncol"},{"key":"715_CR2","doi-asserted-by":"crossref","unstructured":"Park D, Karesen R, Naume B et al (2009) The prognostic impact of occult nodal metastasis in early breast carcinoma. Breast Cancer Res Treat. doi: 10.1007\/s10549-009-0340-2","DOI":"10.1007\/s10549-009-0340-2"},{"key":"715_CR3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1023\/B:BREA.0000004377.12288.3c","volume":"82","author":"GN Naumov","year":"2003","unstructured":"Naumov GN, Townson JL, MacDonald IC et al (2003) Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res Treat 82:199\u2013206. doi: 10.1023\/B:BREA.0000004377.12288.3c","journal-title":"Breast Cancer Res Treat"},{"key":"715_CR4","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1063\/1.1140314","volume":"60","author":"HJ Halpern","year":"1989","unstructured":"Halpern HJ, Spencer DP, Vanpolen J et al (1989) Imaging radio-frequency electron-spin-resonance spectrometer with high-resolution and sensitivity for in vivo measurements. Rev Sci Instrum 60:1040\u20131050","journal-title":"Rev Sci Instrum"},{"key":"715_CR5","first-page":"1","volume-title":"Introduction to magnetic resonance","author":"A Carrington","year":"1967","unstructured":"Carrington A, McLachlan A (1967) Introduction to magnetic resonance. Harper & Row, New York, pp 1\u20134"},{"key":"715_CR6","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1158\/1078-0432.CCR-05-0446","volume":"12","author":"M Elas","year":"2006","unstructured":"Elas M, Ahn KH, Parasca A et al (2006) Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements. Clin Cancer Res 12:4209\u20134217","journal-title":"Clin Cancer Res"},{"key":"715_CR7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ijrobp.2008.02.022","volume":"71","author":"M Elas","year":"2008","unstructured":"Elas M, Bell R, Hleihel D et al (2008) Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas. Int J Radiat Oncol Biol Phys 71:542\u2013549","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"715_CR8","first-page":"5836","volume":"59","author":"HJ Halpern","year":"1999","unstructured":"Halpern HJ, Chandramouli GV, Barth ED et al (1999) Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance. Cancer Res 59:5836\u20135841","journal-title":"Cancer Res"},{"key":"715_CR9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0009-2614(82)87035-8","volume":"91","author":"VV Khramtsov","year":"1982","unstructured":"Khramtsov VV, Weiner LM, Grigoriev IA et al (1982) Proton exchange in stable nitroxyl radicals. EPR study of the pH of aqueous solutions. Chem Phys Lett 91:69\u201372","journal-title":"Chem Phys Lett"},{"key":"715_CR10","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1118\/1.1782677","volume":"31","author":"MR Dreher","year":"2004","unstructured":"Dreher MR, Elas M, Ichikawa K et al (2004) Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Med Phys 31:2755\u20132762","journal-title":"Med Phys"},{"key":"715_CR11","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1073\/pnas.0510670103","volume":"103","author":"H Utsumi","year":"2006","unstructured":"Utsumi H, Yamada K, Ichikawa K et al (2006) Simultaneous molecular imaging of redox reactions monitored by Overhauser-enhanced MRI with 14 N- and 15 N-labeled nitroxyl radicals. Proc Natl Acad Sci USA 103:1463\u20131468","journal-title":"Proc Natl Acad Sci USA"},{"key":"715_CR12","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1039\/b415586f","volume":"3","author":"GM Rosen","year":"2005","unstructured":"Rosen GM, Burks SR, Kohr MJ et al (2005) Synthesis and biological testing of aminoxyls designed for long-term retention by living cells. Org Biomol Chem 3:645\u2013648. doi: 10.1039\/b415586f","journal-title":"Org Biomol Chem"},{"key":"715_CR13","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/mrm.21388","volume":"58","author":"JP Kao","year":"2007","unstructured":"Kao JP, Barth ED, Burks SR et al (2007) Very-low-frequency electron paramagnetic resonance (EPR) imaging of nitroxide-loaded cells. Magn Reson Med 58:850\u2013854. doi: 10.1002\/mrm.21388","journal-title":"Magn Reson Med"},{"key":"715_CR14","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.bbamem.2009.08.007","volume":"1788","author":"SR Burks","year":"2009","unstructured":"Burks SR, Barth ED, Halpern HJ et al (2009) Cellular uptake of electron paramagnetic resonance imaging probes through endocytosis of liposomes. Biochim Biophys Acta 1788:2301\u20132308. doi: 10.1016\/j.bbamem.2009.08.007","journal-title":"Biochim Biophys Acta"},{"key":"715_CR15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-3659(01)00315-7","volume":"74","author":"JW Park","year":"2001","unstructured":"Park JW, Kirpotin DB, Hong K et al (2001) Tumor targeting using anti-her2 immunoliposomes. J Control Release 74:95\u2013113. doi: S0168365901003157","journal-title":"J Control Release"},{"key":"715_CR16","first-page":"1172","volume":"8","author":"JW Park","year":"2002","unstructured":"Park JW, Hong K, Kirpotin DB et al (2002) Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin Cancer Res 8:1172\u20131181","journal-title":"Clin Cancer Res"},{"key":"715_CR17","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.2992089","volume":"229","author":"CR King","year":"1985","unstructured":"King CR, Kraus MH, Aaronson SA (1985) Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science 229:974\u2013976","journal-title":"Science"},{"key":"715_CR18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00918679","volume":"11","author":"HM Shepard","year":"1991","unstructured":"Shepard HM, Lewis GD, Sarup JC et al (1991) Monoclonal antibody therapy of human cancer: taking the HER2 protooncogene to the clinic. J Clin Immunol 11:117\u2013127","journal-title":"J Clin Immunol"},{"key":"715_CR19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/j.1460-2075.1987.tb04797.x","volume":"6","author":"MH Kraus","year":"1987","unstructured":"Kraus MH, Popescu NC, Amsbaugh SC et al (1987) Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J 6:605\u2013610","journal-title":"EMBO J"},{"key":"715_CR20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","volume":"235","author":"DJ Slamon","year":"1987","unstructured":"Slamon DJ, Clark GM, Wong SG et al (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene. Science 235:177\u2013182","journal-title":"Science"},{"key":"715_CR21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01612634","volume":"116","author":"D Marx","year":"1990","unstructured":"Marx D, Schauer A, Reiche C et al (1990) c-erbB2 expression in correlation to other biological parameters of breast cancer. J Cancer Res Clin Oncol 116:15\u201320","journal-title":"J Cancer Res Clin Oncol"},{"key":"715_CR22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.yexcr.2008.10.008","volume":"315","author":"KR Schmitz","year":"2009","unstructured":"Schmitz KR, Ferguson KM (2009) Interaction of antibodies with ErbB receptor extracellular regions. Exp Cell Res 315:659\u2013670. doi: 10.1016\/j.yexcr.2008.10.008","journal-title":"Exp Cell Res"},{"key":"715_CR23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0093-7754(01)90276-3","volume":"28","author":"J Baselga","year":"2001","unstructured":"Baselga J, Albanell J, Molina MA et al (2001) Mechanism of action of trastuzumab and scientific update. Semin Oncol 28:4\u201311. doi: asonc02805n0004","journal-title":"Semin Oncol"},{"key":"715_CR24","first-page":"60","volume":"26","author":"MX Sliwkowski","year":"1999","unstructured":"Sliwkowski MX, Lofgren JA, Lewis GD et al (1999) Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Semin Oncol 26:60\u201370","journal-title":"Semin Oncol"},{"issue":"Suppl 2","key":"715_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000055396","volume":"61","author":"Y Yarden","year":"2001","unstructured":"Yarden Y (2001) Biology of HER2 and its importance in breast cancer. Oncology 61(Suppl 2):1\u201313. doi: ocl1b001","journal-title":"Oncology"},{"key":"715_CR26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1158\/0008-5472.CAN-08-3116","volume":"69","author":"M Ogawa","year":"2009","unstructured":"Ogawa M, Kosaka N, Choyke PL et al (2009) In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. Cancer Res 69:1268\u20131272. doi: 10.1158\/0008-5472.CAN-08-3116","journal-title":"Cancer Res"},{"key":"715_CR27","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2967\/jnumed.108.057919","volume":"50","author":"A Orlova","year":"2009","unstructured":"Orlova A, Wallberg H, Stone-Elander S et al (2009) On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft model. J Nucl Med 50:417\u2013425. doi: 10.2967\/jnumed.108.057919","journal-title":"J Nucl Med"},{"key":"715_CR28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00775-008-0445-9","volume":"14","author":"TJ Chen","year":"2009","unstructured":"Chen TJ, Cheng TH, Chen CY et al (2009) Targeted Herceptin-dextran iron oxide nanoparticles for noninvasive imaging of HER2\/neu receptors using MRI. J Biol Inorg Chem 14:253\u2013260. doi: 10.1007\/s00775-008-0445-9","journal-title":"J Biol Inorg Chem"},{"key":"715_CR29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0079-6638(08)70123-9","volume-title":"Progress in optics XXI","author":"HH Barrett","year":"1984","unstructured":"Barrett HH (1984) The Radon transformation and its applications. In: Wolf E (ed) Progress in optics XXI. Elsevier, Amsterdam, pp 217\u2013286"},{"key":"715_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmr.2007.02.013","volume":"187","author":"KH Ahn","year":"2007","unstructured":"Ahn KH, Halpern HJ (2007) Simulation of 4D spectral-spatial EPR images. J Magn Reson 187:1\u20139","journal-title":"J Magn Reson"},{"key":"715_CR31","first-page":"5400","volume":"55","author":"J Szollosi","year":"1995","unstructured":"Szollosi J, Balazs M, Feuerstein BG et al (1995) ERBB-2 (HER2\/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer. Cancer Res 55:5400\u20135407","journal-title":"Cancer Res"},{"key":"715_CR32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0005-2736(95)00196-4","volume":"1278","author":"F Liu","year":"1996","unstructured":"Liu F, Liu D (1996) Serum independent liposome uptake by mouse liver. Biochim Biophys Acta 1278:5\u201311","journal-title":"Biochim Biophys Acta"},{"key":"715_CR33","first-page":"171","volume":"1113","author":"MC Woodle","year":"1992","unstructured":"Woodle MC, Lasic DD (1992) Sterically stabilized liposomes. BiochimBiophysActa 1113:171\u2013199","journal-title":"BiochimBiophysActa"},{"key":"715_CR34","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1158\/0008-5472.CAN-05-4199","volume":"66","author":"DB Kirpotin","year":"2006","unstructured":"Kirpotin DB, Drummond DC, Shao Y et al (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66:6732\u20136740. doi: 10.1158\/0008-5472.CAN-05-4199","journal-title":"Cancer Res"},{"key":"715_CR35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/187152006778699121","volume":"6","author":"TM Allen","year":"2006","unstructured":"Allen TM, Cheng WW, Hare JI et al (2006) Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer. Anticancer Agents Med Chem 6:513\u2013523","journal-title":"Anticancer Agents Med Chem"},{"key":"715_CR36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0005-2736(02)00661-2","volume":"1609","author":"GJ Charrois","year":"2003","unstructured":"Charrois GJ, Allen TM (2003) Rate of biodistribution of STEALTH liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity. Biochim Biophys Acta 1609:102\u2013108. doi: S0005273602006612","journal-title":"Biochim Biophys Acta"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-009-0715-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-009-0715-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-009-0715-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T12:32:26Z","timestamp":1559219546000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-009-0715-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,12]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["715"],"URL":"https:\/\/doi.org\/10.1007\/s10549-009-0715-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,12]]}}}