{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:54:29Z","timestamp":1773147269483,"version":"3.50.1"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T00:00:00Z","timestamp":1303862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s10549-011-1532-0","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T10:54:02Z","timestamp":1303815242000},"page":"613-624","source":"Crossref","is-referenced-by-count":33,"title":["Axillary lymph node dissection in early-stage invasive breast cancer: is it still standard today?"],"prefix":"10.1007","volume":"128","author":[{"given":"Bernd","family":"Gerber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Heintze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Stubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffi","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angrit","family":"Stachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toralf","family":"Reimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,4,27]]},"reference":[{"key":"1532_CR1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1524-4741.2002.08315.x","volume":"8","author":"GF Schwartz","year":"2002","unstructured":"Schwartz GF, Guiliano AE, Veronesi U (2002) Proceeding of the consensus conference of the role of sentinel lymph node biopsy in carcinoma or the breast April 19\u201322, 2001, Philadelphia, PA, USA. Breast J 8:124\u2013138","journal-title":"Breast J"},{"key":"1532_CR2","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1200\/JCO.2005.08.001","volume":"23","author":"GH Lyman","year":"2005","unstructured":"Lyman GH, Giuliano AE, Somerfield MR et al (2005) American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23:7703\u20137720","journal-title":"J Clin Oncol"},{"key":"1532_CR3","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1470-2045(10)70207-2","volume":"11","author":"DN Krag","year":"2010","unstructured":"Krag DN, Anderson SJ, Julian TB et al (2010) Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol 11:927\u2013933","journal-title":"Lancet Oncol"},{"key":"1532_CR4","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1245\/s10434-008-9909-y","volume":"15","author":"R Crane-Okada","year":"2008","unstructured":"Crane-Okada R, Wascher RA, Elashoff D et al (2008) Long-term morbidity of sentinel node biopsy versus complete axillary dissection for unilateral breast cancer. Ann Surg Oncol 15:1996\u20132005","journal-title":"Ann Surg Oncol"},{"key":"1532_CR5","unstructured":"AGO (2011) Diagnostic and treatment of early and metastatic breast cancer. http:\/\/www.ago-online.org"},{"key":"1532_CR6","unstructured":"NCCN (National Comprehensive Cancer Network) (2011). NCCN practice guidelines in oncology: breast cancer. Version 02.2011. http:\/\/www.nccn.org"},{"key":"1532_CR7","unstructured":"Cochrane Collaboration (2010) http:\/\/www.cochrane.org"},{"key":"1532_CR8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejso.2006.09.032","volume":"33","author":"C Lanng","year":"2007","unstructured":"Lanng C, Hoffmann J, Galatius H et al (2007) Assessment of clinical palpation of the axilla as a criterion for performing the sentinel node procedure in breast cancer. Eur J Surg Oncol 33:281\u2013284","journal-title":"Eur J Surg Oncol"},{"key":"1532_CR9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jamcollsurg.2004.09.010","volume":"200","author":"MC Specht","year":"2005","unstructured":"Specht MC, Fey JV, Borgen PI et al (2005) Is the clinically positive axilla in breast cancer really a contraindication to sentinel lymph node biopsy? J Am Coll Surg 200:10\u201314","journal-title":"J Am Coll Surg"},{"key":"1532_CR10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jso.20590","volume":"94","author":"IM Mathijssen","year":"2006","unstructured":"Mathijssen IM, Strijdhorst H, Kiestra SK et al (2006) Added value of ultrasound in screening the clinically negative axilla in breast cancer. J Surg Oncol 94:364\u2013367","journal-title":"J Surg Oncol"},{"key":"1532_CR11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10549-005-9123-6","volume":"97","author":"J Zgajnar","year":"2006","unstructured":"Zgajnar J, Hocevar M, Podkrajsek M et al (2006) Patients with preoperatively ultrasonically uninvolved axillary lymph nodes: a distinct subgroup of early breast cancer patients. Breast Cancer Res Treat 97:293\u2013299","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR12","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1245\/s10434-010-0919-1","volume":"17","author":"JC Boughey","year":"2010","unstructured":"Boughey JC, Moriarty JP, Degnim AC et al (2010) Cost modeling of preoperative axillary ultrasound and fine-needle aspiration to guide surgery for invasive breast cancer. Ann Surg Oncol 17:953\u2013958","journal-title":"Ann Surg Oncol"},{"key":"1532_CR13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1245\/s10434-010-1347-y","volume":"18","author":"SH Park","year":"2011","unstructured":"Park SH, Kim MJ, Park BW et al (2011) Impact of preoperative ultrasonography and fine-needle aspiration of axillary lymph nodes on surgical management of primary breast cancer. Ann Surg Oncol 18:738\u2013744","journal-title":"Ann Surg Oncol"},{"key":"1532_CR14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/bjs.6964","volume":"97","author":"BP Baruah","year":"2010","unstructured":"Baruah BP, Goyal A, Young P et al (2010) Axillary node staging by ultrasonography and fine-needle aspiration cytology in patients with breast cancer. Br J Surg 97:680\u2013683","journal-title":"Br J Surg"},{"key":"1532_CR15","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2214\/AJR.05.0936","volume":"186","author":"S Alvarez","year":"2006","unstructured":"Alvarez S, Anorbe E, Alcorta P et al (2006) Role of sonography in the diagnosis of axillary lymph node metastases in breast cancer: a systematic review. AJR Am J Roentgenol 186:1342\u20131348","journal-title":"AJR Am J Roentgenol"},{"key":"1532_CR16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ultrasmedbio.2010.10.011","volume":"37","author":"A Garcia Fernandez","year":"2011","unstructured":"Garcia Fernandez A, Fraile M, Gimenez N et al (2011) Use of axillary ultrasound, ultrasound-fine needle aspiration biopsy and magnetic resonance imaging in the preoperative triage of breast cancer patients considered for sentinel node biopsy. Ultrasound Med Biol 37:16\u201322","journal-title":"Ultrasound Med Biol"},{"key":"1532_CR17","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.2214\/AJR.10.4414","volume":"195","author":"MB Mainiero","year":"2010","unstructured":"Mainiero MB, Cinelli CM, Koelliker SL et al (2010) Axillary ultrasound and fine-needle aspiration in the preoperative evaluation of the breast cancer patient: an algorithm based on tumor size and lymph node appearance. AJR Am J Roentgenol 195:1261\u20131267","journal-title":"AJR Am J Roentgenol"},{"key":"1532_CR18","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2214\/AJR.09.3122","volume":"193","author":"N Cho","year":"2009","unstructured":"Cho N, Moon WK, Han W et al (2009) Preoperative sonographic classification of axillary lymph nodes in patients with breast cancer: node-to-node correlation with surgical histology and sentinel node biopsy results. AJR Am J Roentgenol 193:1731\u20131737","journal-title":"AJR Am J Roentgenol"},{"key":"1532_CR19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1055\/s-0028-1109847","volume":"31","author":"I Steppan","year":"2010","unstructured":"Steppan I, Reimer D, Muller-Holzner E et al (2010) Breast cancer in women: evaluation of benign and malignant axillary lymph nodes with contrast-enhanced ultrasound. Ultraschall Med 31:63\u201367","journal-title":"Ultraschall Med"},{"key":"1532_CR20","first-page":"RA37","volume":"13","author":"JS Sloka","year":"2007","unstructured":"Sloka JS, Hollett PD, Mathews M (2007) A quantitative review of the use of FDG-PET in the axillary staging of breast cancer. Med Sci Monit 13:RA37\u2013RA46","journal-title":"Med Sci Monit"},{"key":"1532_CR21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10549-010-0771-9","volume":"123","author":"R Peare","year":"2010","unstructured":"Peare R, Staff RT, Heys SD (2010) The use of FDG-PET in assessing axillary lymph node status in breast cancer: a systematic review and meta-analysis of the literature. Breast Cancer Res Treat 123:281\u2013290","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00259-009-1343-2","volume":"37","author":"ME Straver","year":"2010","unstructured":"Straver ME, Aukema TS, Olmos RA et al (2010) Feasibility of FDG PET\/CT to monitor the response of axillary lymph node metastases to neoadjuvant chemotherapy in breast cancer patients. Eur J Nucl Med Mol Imaging 37:1069\u20131076","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1532_CR23","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/02841851.2010.501342","volume":"51","author":"JH Ahn","year":"2010","unstructured":"Ahn JH, Son EJ, Kim JA et al (2010) The role of ultrasonography and FDG-PET in axillary lymph node staging of breast cancer. Acta Radiol 51:859\u2013865","journal-title":"Acta Radiol"},{"key":"1532_CR24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ejrad.2007.02.010","volume":"63","author":"T Harada","year":"2007","unstructured":"Harada T, Tanigawa N, Matsuki M et al (2007) Evaluation of lymph node metastases of breast cancer using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging. Eur J Radiol 63:401\u2013407","journal-title":"Eur J Radiol"},{"key":"1532_CR25","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00330-006-0276-4","volume":"16","author":"TW Stadnik","year":"2006","unstructured":"Stadnik TW, Everaert H, Makkat S et al (2006) Breast imaging. Preoperative breast cancer staging: comparison of USPIO-enhanced MR imaging and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging for axillary lymph node staging\u2014initial findings. Eur Radiol 16:2153\u20132160","journal-title":"Eur Radiol"},{"key":"1532_CR26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1259\/bjr.75.891.750220","volume":"75","author":"AD Murray","year":"2002","unstructured":"Murray AD, Staff RT, Redpath TW et al (2002) Dynamic contrast enhanced MRI of the axilla in women with breast cancer: comparison with pathology of excised nodes. Br J Radiol 75:220\u2013228","journal-title":"Br J Radiol"},{"key":"1532_CR27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiol.2252011605","volume":"225","author":"SC Michel","year":"2002","unstructured":"Michel SC, Keller TM, Frohlich JM et al (2002) Preoperative breast cancer staging: MR imaging of the axilla with ultrasmall superparamagnetic iron oxide enhancement. Radiology 225:527\u2013536","journal-title":"Radiology"},{"key":"1532_CR28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1148\/radiol.2412050693","volume":"241","author":"M Memarsadeghi","year":"2006","unstructured":"Memarsadeghi M, Riedl CC, Kaneider A et al (2006) Axillary lymph node metastases in patients with breast carcinomas: assessment with nonenhanced versus uspio-enhanced MR imaging. Radiology 241:367\u2013377","journal-title":"Radiology"},{"key":"1532_CR29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02967550","volume":"9","author":"T Suzuma","year":"2002","unstructured":"Suzuma T, Sakurai T, Yoshimura G et al (2002) MR-axillography oriented surgical sampling for assessment of nodal status in the selection of patients with breast cancer for axillary lymph nodes dissection. Breast Cancer 9:69\u201374","journal-title":"Breast Cancer"},{"key":"1532_CR30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/jmri.10134","volume":"16","author":"C Stets","year":"2002","unstructured":"Stets C, Brandt S, Wallis F et al (2002) Axillary lymph node metastases: a statistical analysis of various parameters in MRI with USPIO. J Magn Reson Imaging 16:60\u201368","journal-title":"J Magn Reson Imaging"},{"key":"1532_CR31","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2214\/ajr.183.6.01831805","volume":"183","author":"K Kitagawa","year":"2004","unstructured":"Kitagawa K, Sakuma H, Ishida N et al (2004) Contrast-enhanced high-resolution MRI of invasive breast cancer: correlation with histopathologic subtypes. AJR Am J Roentgenol 183:1805\u20131809","journal-title":"AJR Am J Roentgenol"},{"key":"1532_CR32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10549-006-9400-z","volume":"104","author":"TF Bathen","year":"2007","unstructured":"Bathen TF, Jensen LR, Sitter B et al (2007) MR-determined metabolic phenotype of breast cancer in prediction of lymphatic spread, grade, and hormone status. Breast Cancer Res Treat 104:181\u2013189","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3816\/CBC.2010.n.033","volume":"10","author":"KA Gelmon","year":"2010","unstructured":"Gelmon KA (2010) The ongoing debate about nodes. Clin Breast Cancer 10:265\u2013266","journal-title":"Clin Breast Cancer"},{"key":"1532_CR34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijrobp.2009.04.073","volume":"77","author":"P Tai","year":"2010","unstructured":"Tai P, Yu E, Joseph K (2010) Prognostic significance of number of positive nodes: a long-term study of one to two nodes versus three nodes in breast cancer patients. Int J Radiat Oncol Biol Phys 77:180\u2013187","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1532_CR35","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1245\/s10434-009-0653-8","volume":"16","author":"HA Hatoum","year":"2009","unstructured":"Hatoum HA, Jamali FR, El Saghir NS et al (2009) Ratio between positive lymph nodes and total excised axillary lymph nodes as an independent prognostic factor for overall survival in patients with nonmetastatic lymph node-positive breast cancer. Ann Surg Oncol 16:3388\u20133395","journal-title":"Ann Surg Oncol"},{"key":"1532_CR36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3816\/CBC.2008.n.028","volume":"8","author":"SJ Crabb","year":"2008","unstructured":"Crabb SJ, Cheang MC, Leung S et al (2008) Basal breast cancer molecular subtype predicts for lower incidence of axillary lymph node metastases in primary breast cancer. Clin Breast Cancer 8:249\u2013256","journal-title":"Clin Breast Cancer"},{"key":"1532_CR37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10549-008-9914-7","volume":"113","author":"B Calster Van","year":"2009","unstructured":"Van Calster B, Vanden Bempt I, Drijkoningen M et al (2009) Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive. Breast Cancer Res Treat 113:181\u2013187","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR38","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1200\/JCO.2008.16.7619","volume":"27","author":"H Wildiers","year":"2009","unstructured":"Wildiers H, Van Calster B, van de Poll-Franse LV et al (2009) Relationship between age and axillary lymph node involvement in women with breast cancer. J Clin Oncol 27:2931\u20132937","journal-title":"J Clin Oncol"},{"key":"1532_CR39","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3816\/CBC.2010.n.042","volume":"10","author":"E Botteri","year":"2010","unstructured":"Botteri E, Bagnardi V, Goldhirsch A et al (2010) Axillary lymph node involvement in women with breast cancer: does it depend on age? Clin Breast Cancer 10:318\u2013321","journal-title":"Clin Breast Cancer"},{"key":"1532_CR40","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","volume":"28","author":"H Kennecke","year":"2010","unstructured":"Kennecke H, Yerushalmi R, Woods R et al (2010) Metastatic behavior of breast cancer subtypes. J Clin Oncol 28:3271\u20133277","journal-title":"J Clin Oncol"},{"key":"1532_CR41","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1200\/JCO.2009.24.9284","volume":"28","author":"KD Voduc","year":"2010","unstructured":"Voduc KD, Cheang MC, Tyldesley S et al (2010) Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol 28:1684\u20131691","journal-title":"J Clin Oncol"},{"key":"1532_CR42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10549-008-0102-6","volume":"117","author":"WD Foulkes","year":"2009","unstructured":"Foulkes WD, Grainge MJ, Rakha EA et al (2009) Tumor size is an unreliable predictor of prognosis in basal-like breast cancers and does not correlate closely with lymph node status. Breast Cancer Res Treat 117:199\u2013204","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR43","doi-asserted-by":"crossref","first-page":"e1000279","DOI":"10.1371\/journal.pmed.1000279","volume":"7","author":"FM Blows","year":"2010","unstructured":"Blows FM, Driver KE, Schmidt MK et al (2010) Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10, 159 cases from 12 studies. PLoS Med 7:e1000279","journal-title":"PLoS Med"},{"key":"1532_CR44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.semradonc.2009.05.004","volume":"19","author":"KE Huber","year":"2009","unstructured":"Huber KE, Carey LA, Wazer DE (2009) Breast cancer molecular subtypes in patients with locally advanced disease: impact on prognosis, patterns of recurrence, and response to therapy. Semin Radiat Oncol 19:204\u2013210","journal-title":"Semin Radiat Oncol"},{"key":"1532_CR45","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","volume":"347","author":"MJ Vijver van de","year":"2002","unstructured":"van de Vijver MJ, He YD, van\u2019t Veer LJ et al (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347:1999\u20132009","journal-title":"N Engl J Med"},{"key":"1532_CR46","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","volume":"98","author":"T Sorlie","year":"2001","unstructured":"Sorlie T, Perou CM, Tibshirani R et al (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98:10869\u201310874","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1532_CR47","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1245\/s10434-007-9670-7","volume":"15","author":"T Reimer","year":"2008","unstructured":"Reimer T, Fietkau R, Markmann S et al (2008) How important is the axillary nodal status for adjuvant treatment decisions at a breast cancer multidisciplinary tumor board? A survival analysis. Ann Surg Oncol 15:472\u2013477","journal-title":"Ann Surg Oncol"},{"key":"1532_CR48","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1056\/NEJMoa0910320","volume":"363","author":"M Martin","year":"2010","unstructured":"Martin M, Segui MA, Anton A et al (2010) Adjuvant docetaxel for high-risk, node-negative breast cancer. N Engl J Med 363:2200\u20132210","journal-title":"N Engl J Med"},{"key":"1532_CR49","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/annonc\/mdn005","volume":"19","author":"M Untch","year":"2008","unstructured":"Untch M, Gelber RD, Jackisch C et al (2008) Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial. Ann Oncol 19:1090\u20131096","journal-title":"Ann Oncol"},{"key":"1532_CR50","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.breast.2005.05.009","volume":"15","author":"J Engel","year":"2006","unstructured":"Engel J, Lebeau A, Sauer H et al (2006) Are we wasting our time with the sentinel technique? Fifteen reasons to stop axilla dissection. Breast 15:452\u2013455","journal-title":"Breast"},{"key":"1532_CR51","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1200\/JCO.2009.25.9226","volume":"28","author":"HG Moon","year":"2010","unstructured":"Moon HG, Han W, Noh DY (2010) Comparable survival between pN0 breast cancer patients undergoing sentinel node biopsy and extensive axillary dissection: a report from the Korean Breast Cancer Society. J Clin Oncol 28:1692\u20131699","journal-title":"J Clin Oncol"},{"key":"1532_CR52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10549-009-0705-6","volume":"120","author":"MR Kell","year":"2010","unstructured":"Kell MR, Burke JP, Barry M et al (2010) Outcome of axillary staging in early breast cancer: a meta-analysis. Breast Cancer Res Treat 120:441\u2013447","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR53","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1200\/JCO.2010.28.2491","volume":"28","author":"SR Land","year":"2010","unstructured":"Land SR, Kopec JA, Julian TB et al (2010) Patient-reported outcomes in sentinel node-negative adjuvant breast cancer patients receiving sentinel-node biopsy or axillary dissection: National Surgical Adjuvant Breast and Bowel Project phase III protocol B-32. J Clin Oncol 28:3929\u20133936","journal-title":"J Clin Oncol"},{"key":"1532_CR54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1200\/JCO.2005.01.5784","volume":"24","author":"CM Rudenstam","year":"2006","unstructured":"Rudenstam CM, Zahrieh D, Forbes JF et al (2006) Randomized trial comparing axillary clearance versus no axillary clearance in older patients with breast cancer: first results of International Breast Cancer Study Group Trial 10\u201393. J Clin Oncol 24:337\u2013344","journal-title":"J Clin Oncol"},{"key":"1532_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000167759.15670.14","volume":"242","author":"G Martelli","year":"2005","unstructured":"Martelli G, Boracchi P, De Palo M et al (2005) A randomized trial comparing axillary dissection to no axillary dissection in older patients with T1N0 breast cancer: results after 5\u00a0years of follow-up. Ann Surg 242:1\u20136","journal-title":"Ann Surg"},{"key":"1532_CR56","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/annonc\/mdi089","volume":"16","author":"U Veronesi","year":"2005","unstructured":"Veronesi U, Orecchia R, Zurrida S et al (2005) Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy. Ann Oncol 16:383\u2013388","journal-title":"Ann Oncol"},{"key":"1532_CR57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1245\/s10434-010-1217-7","volume":"18","author":"G Martelli","year":"2011","unstructured":"Martelli G, Miceli R, Daidone MG et al (2011) Axillary dissection versus no axillary dissection in elderly patients with breast cancer and no palpable axillary nodes: results after 15 years of follow-up. Ann Surg Oncol 18:125\u2013133","journal-title":"Ann Surg Oncol"},{"key":"1532_CR58","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1046\/j.1365-2168.2002.02117.x","volume":"89","author":"I Fredriksson","year":"2002","unstructured":"Fredriksson I, Liljegren G, Arnesson LG et al (2002) Consequences of axillary recurrence after conservative breast surgery. Br J Surg 89:902\u2013908","journal-title":"Br J Surg"},{"key":"1532_CR59","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1200\/JCO.2004.12.108","volume":"22","author":"C Louis-Sylvestre","year":"2004","unstructured":"Louis-Sylvestre C, Clough K, Asselain B et al (2004) Axillary treatment in conservative management of operable breast cancer: dissection or radiotherapy? Results of a randomized study with 15\u00a0years of follow-up. J Clin Oncol 22:97\u2013101","journal-title":"J Clin Oncol"},{"key":"1532_CR60","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3816\/CBC.2002.n.034","volume":"3","author":"R Bourez","year":"2002","unstructured":"Bourez R, Rutgers E, van de Velde C (2002) Will we need lymph node dissection at all in the future? Clin Breast Cancer 3:315\u2013322","journal-title":"Clin Breast Cancer"},{"key":"1532_CR61","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1245\/s10434-010-0945-z","volume":"17","author":"ME Straver","year":"2010","unstructured":"Straver ME, Meijnen P, van Tienhoven G et al (2010) Sentinel node identification rate and nodal involvement in the EORTC 10981\u201322023 AMAROS trial. Ann Surg Oncol 17:1854\u20131861","journal-title":"Ann Surg Oncol"},{"key":"1532_CR62","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/COC.0b013e318161dc1b","volume":"31","author":"SB Evans","year":"2008","unstructured":"Evans SB, Gass J, Wazer DE (2008) Management of the axilla after the finding of a positive sentinel lymph node: a proposal for an evidence-based risk-adapted algorithm. Am J Clin Oncol 31:293\u2013299","journal-title":"Am J Clin Oncol"},{"key":"1532_CR63","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1470-2045(07)70278-4","volume":"8","author":"DN Krag","year":"2007","unstructured":"Krag DN, Anderson SJ, Julian TB et al (2007) Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol 8:881\u2013888","journal-title":"Lancet Oncol"},{"key":"1532_CR64","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0748-7983(98)91381-6","volume":"24","author":"G Canavese","year":"1998","unstructured":"Canavese G, Catturich A, Vecchio C et al (1998) Prognostic role of lymph-node level involvement in patients undergoing axillary dissection for breast cancer. Eur J Surg Oncol 24:104\u2013109","journal-title":"Eur J Surg Oncol"},{"key":"1532_CR65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11912-009-0004-8","volume":"11","author":"KM Erb","year":"2009","unstructured":"Erb KM, Julian TB (2009) Completion of axillary dissection for a positive sentinel node: necessary or not? Curr Oncol Rep 11:15\u201320","journal-title":"Curr Oncol Rep"},{"key":"1532_CR66","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijrobp.2009.04.059","volume":"77","author":"JY Wo","year":"2010","unstructured":"Wo JY, Taghian AG, Nguyen PL et al (2010) The association between biological subtype and isolated regional nodal failure after breast-conserving therapy. Int J Radiat Oncol Biol Phys 77:188\u2013196","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1532_CR67","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1200\/JCO.2005.04.3273","volume":"24","author":"IL Wapnir","year":"2006","unstructured":"Wapnir IL, Anderson SJ, Mamounas EP et al (2006) Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in five National Surgical Adjuvant Breast and Bowel Project node-positive adjuvant breast cancer trials. J Clin Oncol 24:2028\u20132037","journal-title":"J Clin Oncol"},{"key":"1532_CR68","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/SLA.0b013e3181f08f32","volume":"252","author":"AE Giuliano","year":"2010","unstructured":"Giuliano AE, McCall L, Beitsch P et al (2010) Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg 252:426\u2013432","journal-title":"Ann Surg"},{"key":"1532_CR69","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1001\/jama.2011.90","volume":"305","author":"AE Giuliano","year":"2011","unstructured":"Giuliano AE, Hunt KK, Ballman KV et al (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis. JAMA 305:569\u2013575","journal-title":"JAMA"},{"key":"1532_CR70","doi-asserted-by":"crossref","first-page":"S343","DOI":"10.1245\/s10434-010-1253-3","volume":"17","author":"M Yi","year":"2010","unstructured":"Yi M, Giordano SH, Meric-Bernstam F et al (2010) Trends in and outcomes from sentinel lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for node-positive breast cancer patients: experience from the SEER database. Ann Surg Oncol 17:S343\u2013S351","journal-title":"Ann Surg Oncol"},{"key":"1532_CR71","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1200\/JCO.2008.19.5750","volume":"27","author":"KY Bilimoria","year":"2009","unstructured":"Bilimoria KY, Bentrem DJ, Hansen NM et al (2009) Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer. J Clin Oncol 27:2946\u20132953","journal-title":"J Clin Oncol"},{"key":"1532_CR72","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0959-8049(99)00133-1","volume":"35","author":"U Veronesi","year":"1999","unstructured":"Veronesi U, Marubini E, Mariani L et al (1999) The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial. Eur J Cancer 35:1320\u20131325","journal-title":"Eur J Cancer"},{"key":"1532_CR73","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00432-003-0465-3","volume":"129","author":"W Janni","year":"2003","unstructured":"Janni W, Rack B, Sommer H et al (2003) Intra-mammary tumor location does not influence prognosis but influences the prevalence of axillary lymph-node metastases. J Cancer Res Clin Oncol 129:503\u2013510","journal-title":"J Cancer Res Clin Oncol"},{"key":"1532_CR74","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0959-8049(02)00124-7","volume":"38","author":"PS Sinha","year":"2002","unstructured":"Sinha PS, Thrush S, Bendall S et al (2002) Does radical surgery to the axilla give a survival advantage in more severe breast cancer? Eur J Cancer 38:1474\u20131477","journal-title":"Eur J Cancer"},{"key":"1532_CR75","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1245\/ASO.2003.03.015","volume":"10","author":"KJ Zee Van","year":"2003","unstructured":"Van Zee KJ, Manasseh DM, Bevilacqua JL et al (2003) A nomogram for predicting the likelihood in breast cancer patients with a positive sentinel node biopsy. Ann Surg Oncol 10:1140\u20131151","journal-title":"Ann Surg Oncol"},{"key":"1532_CR76","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1200\/JCO.2006.08.8013","volume":"25","author":"JL Bevilacqua","year":"2007","unstructured":"Bevilacqua JL, Kattan MW, Fey JV et al (2007) Doctor, what are my chances of having a positive sentinel node? A validated nomogram for risk estimation. J Clin Oncol 25:3670\u20133679","journal-title":"J Clin Oncol"},{"key":"1532_CR77","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1245\/ASO.2005.06.037","volume":"12","author":"MC Specht","year":"2005","unstructured":"Specht MC, Kattan MW, Fey J et al (2005) Predicting nonsentinel node status after positive sentinel lymph node biopsy for breast cancer: clinicians versus nomogram. Ann Surg Oncol 12:654\u2013659","journal-title":"Ann Surg Oncol"},{"key":"1532_CR78","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1245\/s10434-006-9331-2","volume":"14","author":"S Alran","year":"2007","unstructured":"Alran S, De Rycke Y, Fourchotte V et al (2007) Validation and limitations of use of a breast cancer nomogram predicting the likelihood of non-sentinel node involvement after positive sentinel node biopsy. Ann Surg Oncol 14:2195\u20132201","journal-title":"Ann Surg Oncol"},{"key":"1532_CR79","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/bjs.4725","volume":"91","author":"G Cserni","year":"2004","unstructured":"Cserni G, Gregori D, Merletti F et al (2004) Meta-analysis of non-sentinel node metastases associated with micrometastatic sentinel nodes in breast cancer. Br J Surg 91:1245\u20131252","journal-title":"Br J Surg"},{"key":"1532_CR80","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1245\/s10434-009-0660-9","volume":"16","author":"I Langer","year":"2009","unstructured":"Langer I, Guller U, Viehl CT et al (2009) Axillary lymph node dissection for sentinel lymph node micrometastases may be safely omitted in early-stage breast cancer patients: long-term outcomes of a prospective study. Ann Surg Oncol 16:3366\u20133374","journal-title":"Ann Surg Oncol"},{"key":"1532_CR81","doi-asserted-by":"crossref","first-page":"869","DOI":"10.5858\/133.6.869","volume":"133","author":"AA Sahin","year":"2009","unstructured":"Sahin AA, Guray M, Hunt KK (2009) Identification and biologic significance of micrometastases in axillary lymph nodes in patients with invasive breast cancer. Arch Pathol Lab Med 133:869\u2013878","journal-title":"Arch Pathol Lab Med"},{"key":"1532_CR82","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/S0959-8049(03)00203-X","volume":"39","author":"G Cserni","year":"2003","unstructured":"Cserni G, Amendoeira I, Apostolikas N et al (2003) Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines. Eur J Cancer 39:1654\u20131667","journal-title":"Eur J Cancer"},{"key":"1532_CR83","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1200\/JCO.2007.13.0179","volume":"26","author":"RR Turner","year":"2008","unstructured":"Turner RR, Weaver DL, Cserni G et al (2008) Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training. J Clin Oncol 26:258\u2013263","journal-title":"J Clin Oncol"},{"key":"1532_CR84","first-page":"2434","volume":"7","author":"N Klauber-DeMore","year":"2001","unstructured":"Klauber-DeMore N, Van Zee KJ, Linkov I et al (2001) Biological behavior of human breast cancer micrometastases. Clin Cancer Res 7:2434\u20132439","journal-title":"Clin Cancer Res"},{"key":"1532_CR85","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/cncr.23368","volume":"112","author":"I Mascarel de","year":"2008","unstructured":"de Mascarel I, MacGrogan G, Debled M et al (2008) Distinction between isolated tumor cells and micrometastases in breast cancer: is it reliable and useful? Cancer 112:1672\u20131678","journal-title":"Cancer"},{"key":"1532_CR86","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1200\/JCO.2007.12.6425","volume":"26","author":"LK Tan","year":"2008","unstructured":"Tan LK, Giri D, Hummer AJ et al (2008) Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node-negative patients with 20-year follow-up. J Clin Oncol 26:1803\u20131809","journal-title":"J Clin Oncol"},{"key":"1532_CR87","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archsurg.2010.84","volume":"145","author":"S Yegiyants","year":"2010","unstructured":"Yegiyants S, Romero LM, Haigh PI et al (2010) Completion axillary lymph node dissection not required for regional control in patients with breast cancer who have micrometastases in a sentinel node. Arch Surg 145:564\u2013569","journal-title":"Arch Surg"},{"key":"1532_CR88","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1200\/JCO.2001.19.4.960","volume":"19","author":"B Gerber","year":"2001","unstructured":"Gerber B, Krause A, Muller H et al (2001) Simultaneous immunohistochemical detection of tumor cells in lymph nodes and bone marrow aspirates in breast cancer and its correlation with other prognostic factors. J Clin Oncol 19:960\u2013971","journal-title":"J Clin Oncol"},{"key":"1532_CR89","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1056\/NEJMoa0904832","volume":"361","author":"M Boer de","year":"2009","unstructured":"de Boer M, van Deurzen CH, van Dijck JA et al (2009) Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med 361:653\u2013663","journal-title":"N Engl J Med"},{"key":"1532_CR90","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1200\/JCO.2009.26.7575","volume":"28","author":"PJ Diest van","year":"2010","unstructured":"van Diest PJ, de Boer M, van Deurzen CH et al (2010) Micrometastases and isolated tumor cells in breast cancer are indeed associated with poorer outcome. J Clin Oncol 28:e140\u2013e142","journal-title":"J Clin Oncol"},{"key":"1532_CR91","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1200\/JCO.2008.19.0686","volume":"27","author":"NM Hansen","year":"2009","unstructured":"Hansen NM, Grube B, Ye X et al (2009) Impact of micrometastases in the sentinel node of patients with invasive breast cancer. J Clin Oncol 27:4679\u20134684","journal-title":"J Clin Oncol"},{"key":"1532_CR92","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jamcollsurg.2008.10.036","volume":"208","author":"J Reed","year":"2009","unstructured":"Reed J, Rosman M, Verbanac KM et al (2009) Prognostic implications of isolated tumor cells and micrometastases in sentinel nodes of patients with invasive breast cancer: 10-year analysis of patients enrolled in the prospective East Carolina University\/Anne Arundel Medical Center Sentinel Node Multicenter Study. J Am Coll Surg 208:333\u2013340","journal-title":"J Am Coll Surg"},{"key":"1532_CR93","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.ejso.2008.01.034","volume":"34","author":"I Ploeg van der","year":"2008","unstructured":"van der Ploeg I, Nieweg OE, van Rijk MC et al (2008) Axillary recurrence after a tumour-negative sentinel node biopsy in breast cancer patients: a systematic review and meta-analysis of the literature. Eur J Surg Oncol 34:1277\u20131284","journal-title":"Eur J Surg Oncol"},{"key":"1532_CR94","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/annonc\/mdp453","volume":"21","author":"G Masci","year":"2010","unstructured":"Masci G, Di Tommaso L, Del Prato I et al (2010) Sinusal localization of nodal micrometastases is a prognostic factor in breast cancer. Ann Oncol 21:1228\u20131232","journal-title":"Ann Oncol"},{"key":"1532_CR95","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/jnci\/djq008","volume":"102","author":"M Boer de","year":"2010","unstructured":"de Boer M, van Dijck JA, Bult P et al (2010) Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases. J Natl Cancer Inst 102:410\u2013425","journal-title":"J Natl Cancer Inst"},{"key":"1532_CR96","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1008108","volume":"364","author":"DL Weaver","year":"2011","unstructured":"Weaver DL, Ashikaga T, Krag DN et al (2011) Effect of occult metastases on survival in node-negative breast cancer. N Engl J Med 364:412\u2013421","journal-title":"N Engl J Med"},{"key":"1532_CR97","doi-asserted-by":"crossref","unstructured":"Maaskant-Braat AJ, van de Poll-Franse LV, Voogd AC et al (2010) Sentinel node micrometastases in breast cancer do not affect prognosis: a population-based study. Breast Cancer Res Treat. doi: 10.1007\/s10549-010-1086-6","DOI":"10.1007\/s10549-010-1086-6"},{"key":"1532_CR98","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10549-009-0446-6","volume":"118","author":"E Montagna","year":"2009","unstructured":"Montagna E, Viale G, Rotmensz N et al (2009) Minimal axillary lymph node involvement in breast cancer has different prognostic implications according to the staging procedure. Breast Cancer Res Treat 118:385\u2013394","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR99","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/annonc\/mdn535","volume":"20","author":"PD Gobardhan","year":"2009","unstructured":"Gobardhan PD, Elias SG, Madsen EV et al (2009) Prognostic value of micrometastases in sentinel lymph nodes of patients with breast carcinoma: a cohort study. Ann Oncol 20:41\u201348","journal-title":"Ann Oncol"},{"key":"1532_CR100","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jamcollsurg.2007.08.024","volume":"206","author":"CE Cox","year":"2008","unstructured":"Cox CE, Kiluk JV, Riker AI et al (2008) Significance of sentinel lymph node micrometastases in human breast cancer. J Am Coll Surg 206:261\u2013268","journal-title":"J Am Coll Surg"},{"key":"1532_CR101","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2325\/jbcs.13.186","volume":"13","author":"T Nagashima","year":"2006","unstructured":"Nagashima T, Sakakibara M, Nakano S et al (2006) Sentinel node micrometastasis and distant failure in breast cancer patients. Breast Cancer 13:186\u2013191","journal-title":"Breast Cancer"},{"key":"1532_CR102","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.ejso.2006.08.006","volume":"32","author":"S Imoto","year":"2006","unstructured":"Imoto S, Ochiai A, Okumura C et al (2006) Impact of isolated tumor cells in sentinel lymph nodes detected by immunohistochemical staining. Eur J Surg Oncol 32:1175\u20131179","journal-title":"Eur J Surg Oncol"},{"key":"1532_CR103","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1245\/ASO.2005.08.020","volume":"12","author":"YG Fan","year":"2005","unstructured":"Fan YG, Tan YY, Wu CT et al (2005) The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer. Ann Surg Oncol 12:705\u2013711","journal-title":"Ann Surg Oncol"},{"key":"1532_CR104","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.1245\/s10434-010-1255-1","volume":"17","author":"A Cyr","year":"2010","unstructured":"Cyr A, Gillanders WE, Aft RL et al (2010) Micrometastatic disease and isolated tumor cells as a predictor for additional breast cancer axillary metastatic burden. Ann Surg Oncol 17:S303\u2013S311","journal-title":"Ann Surg Oncol"},{"key":"1532_CR105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/path.1544","volume":"203","author":"CR Tait","year":"2004","unstructured":"Tait CR, Dodwell D, Horgan K (2004) Do metastases metastasize? J Pathol 203:515\u2013518","journal-title":"J Pathol"},{"key":"1532_CR106","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/418823a","volume":"418","author":"R Bernards","year":"2002","unstructured":"Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418:823","journal-title":"Nature"},{"key":"1532_CR107","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1158\/0008-5472.CAN-09-3739","volume":"70","author":"X Lu","year":"2010","unstructured":"Lu X, Yan CH, Yuan M et al (2010) In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res 70:3905\u20133914","journal-title":"Cancer Res"},{"key":"1532_CR108","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10911-007-9047-3","volume":"12","author":"X Lu","year":"2007","unstructured":"Lu X, Kang Y (2007) Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia 12:153\u2013162","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"1532_CR109","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1158\/0008-5472.CAN-07-5644","volume":"68","author":"M Smid","year":"2008","unstructured":"Smid M, Wang Y, Zhang Y et al (2008) Subtypes of breast cancer show preferential site of relapse. Cancer Res 68:3108\u20133114","journal-title":"Cancer Res"},{"key":"1532_CR110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pathophys.2009.11.003","volume":"17","author":"S Ran","year":"2010","unstructured":"Ran S, Volk L, Hall K et al (2010) Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 17:229\u2013251","journal-title":"Pathophysiology"},{"key":"1532_CR111","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1126\/science.152.3727.1397","volume":"152","author":"B Fisher","year":"1966","unstructured":"Fisher B, Fisher ER (1966) Transmigration of lymph nodes by tumor cells. Science 152:1397\u20131398","journal-title":"Science"},{"key":"1532_CR112","first-page":"713","volume":"63","author":"J Krishnan","year":"2003","unstructured":"Krishnan J, Kirkin V, Steffen A et al (2003) Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res 63:713\u2013722","journal-title":"Cancer Res"},{"key":"1532_CR113","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1182\/blood-2006-05-021758","volume":"109","author":"S Hirakawa","year":"2007","unstructured":"Hirakawa S, Brown LF, Kodama S et al (2007) VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 109:1010\u20131017","journal-title":"Blood"},{"key":"1532_CR114","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjc.6603678","volume":"96","author":"RA Mohammed","year":"2007","unstructured":"Mohammed RA, Green A, El Shikh S et al (2007) Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer 96:1092\u20131100","journal-title":"Br J Cancer"},{"key":"1532_CR115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10549-004-5783-x","volume":"91","author":"Y Nakamura","year":"2005","unstructured":"Nakamura Y, Yasuoka H, Tsujimoto M et al (2005) Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast Cancer Res Treat 91:125\u2013132","journal-title":"Breast Cancer Res Treat"},{"key":"1532_CR116","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1471-2407-8-340","volume":"8","author":"H Yasuoka","year":"2008","unstructured":"Yasuoka H, Tsujimoto M, Yoshidome K et al (2008) Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis. BMC Cancer 8:340","journal-title":"BMC Cancer"},{"key":"1532_CR117","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1158\/1078-0432.CCR-05-0014","volume":"11","author":"N Cabioglu","year":"2005","unstructured":"Cabioglu N, Yazici MS, Arun B et al (2005) CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer. Clin Cancer Res 11:5686\u20135693","journal-title":"Clin Cancer Res"},{"key":"1532_CR118","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/annonc\/mdp427","volume":"21","author":"SJ Aitken","year":"2010","unstructured":"Aitken SJ, Thomas JS, Langdon SP et al (2010) Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases. Ann Oncol 21:1254\u20131261","journal-title":"Ann Oncol"},{"key":"1532_CR119","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrc1098","volume":"3","author":"IJ Fidler","year":"2003","unstructured":"Fidler IJ (2003) The pathogenesis of cancer metastasis: the \u2018seed and soil\u2019 hypothesis revisited. Nat Rev Cancer 3:453\u2013458","journal-title":"Nat Rev Cancer"},{"key":"1532_CR120","doi-asserted-by":"crossref","first-page":"812","DOI":"10.4161\/cc.5.8.2646","volume":"5","author":"SY Wong","year":"2006","unstructured":"Wong SY, Hynes RO (2006) Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle 5:812\u2013817","journal-title":"Cell Cycle"},{"key":"1532_CR121","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/jnci\/91.13.1113","volume":"91","author":"K Pantel","year":"1999","unstructured":"Pantel K, Cote RJ, Fodstad O (1999) Detection and clinical importance of micrometastatic disease. J Natl Cancer Inst 91:1113\u20131124","journal-title":"J Natl Cancer Inst"},{"key":"1532_CR122","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/ijc.21576","volume":"118","author":"G Wiedswang","year":"2006","unstructured":"Wiedswang G, Borgen E, Schirmer C et al (2006) Comparison of the clinical significance of occult tumor cells in blood and bone marrow in breast cancer. Int J Cancer 118:2013\u20132019","journal-title":"Int J Cancer"},{"key":"1532_CR123","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/annonc\/mdp391","volume":"21","author":"FC Bidard","year":"2010","unstructured":"Bidard FC, Mathiot C, Delaloge S et al (2010) Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer. Ann Oncol 21:729\u2013733","journal-title":"Ann Oncol"},{"key":"1532_CR124","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/annonc\/mdm507","volume":"19","author":"FC Bidard","year":"2008","unstructured":"Bidard FC, Vincent-Salomon A, Sigal-Zafrani B et al (2008) Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells. Ann Oncol 19:496\u2013500","journal-title":"Ann Oncol"},{"key":"1532_CR125","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1073\/pnas.1331931100","volume":"100","author":"O Schmidt-Kittler","year":"2003","unstructured":"Schmidt-Kittler O, Ragg T, Daskalakis A et al (2003) From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci USA 100:7737\u20137742","journal-title":"Proc Natl Acad Sci USA"},{"key":"1532_CR126","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ccr.2005.08.003","volume":"8","author":"JA Schardt","year":"2005","unstructured":"Schardt JA, Meyer M, Hartmann CH et al (2005) Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 8:227\u2013239","journal-title":"Cancer Cell"},{"key":"1532_CR127","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.canlet.2009.06.027","volume":"288","author":"PA Theodoropoulos","year":"2010","unstructured":"Theodoropoulos PA, Polioudaki H, Agelaki S et al (2010) Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer. Cancer Lett 288:99\u2013106","journal-title":"Cancer Lett"},{"key":"1532_CR128","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1200\/JCO.2009.27.5388","volume":"28","author":"S Liu","year":"2010","unstructured":"Liu S, Wicha MS (2010) Targeting breast cancer stem cells. J Clin Oncol 28:4006\u20134012","journal-title":"J Clin Oncol"},{"key":"1532_CR129","doi-asserted-by":"crossref","unstructured":"McDermott SP, Wicha MS (2010) Targeting breast cancer stem cells. Mol Oncol 4(5):404\u2013419","DOI":"10.1016\/j.molonc.2010.06.005"},{"key":"1532_CR130","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1200\/JCO.2008.16.3931","volume":"26","author":"M Kakarala","year":"2008","unstructured":"Kakarala M, Wicha MS (2008) Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 26:2813\u20132820","journal-title":"J Clin Oncol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-011-1532-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-011-1532-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-011-1532-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T06:33:30Z","timestamp":1637562810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-011-1532-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,27]]},"references-count":130,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["1532"],"URL":"https:\/\/doi.org\/10.1007\/s10549-011-1532-0","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,27]]}}}