{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:57:58Z","timestamp":1791356278480,"version":"4.3.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,6,24]],"date-time":"2011-06-24T00:00:00Z","timestamp":1308873600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s10549-011-1635-7","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T12:06:14Z","timestamp":1308830774000},"page":"937-945","source":"Crossref","is-referenced-by-count":33,"title":["Different CHEK2 germline mutations are associated with distinct immunophenotypic molecular subtypes of breast cancer"],"prefix":"10.1007","volume":"132","author":[{"given":"Pawel","family":"Domagala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Wokolorczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Cybulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Huzarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenancjusz","family":"Domagala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,24]]},"reference":[{"key":"1635_CR1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nrc2251","volume":"7","author":"L Antoni","year":"2007","unstructured":"Antoni L, Sodha N, Collins I, Garrett MD (2007) CHK2 kinase: cancer susceptibility and cancer therapy\u2014two sides of the same coin? Nat Rev Cancer 7:925\u2013936","journal-title":"Nat Rev Cancer"},{"key":"1635_CR2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/jama.295.12.1379","volume":"295","author":"T Walsh","year":"2006","unstructured":"Walsh T, Casadei S, Coats KH, Swisher E, Stray SM, Higgins J, Roach KC, Mandell J, Lee MK, Ciernikova S, Foretova L, Soucek P, King MC (2006) Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. JAMA 295:1379\u20131388","journal-title":"JAMA"},{"key":"1635_CR3","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1158\/0008-5472.CAN-06-1990","volume":"66","author":"N Sodha","year":"2006","unstructured":"Sodha N, Mantoni TS, Tavtigian SV, Eeles R, Garrett MD (2006) Rare germ line CHEK2 variants identified in breast cancer families encode proteins that show impaired activation. Cancer Res 66:8966\u20138970","journal-title":"Cancer Res"},{"key":"1635_CR4","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1074\/jbc.M009727200","volume":"276","author":"X Wu","year":"2001","unstructured":"Wu X, Webster SR, Chen J (2001) Characterization of tumor-associated Chk2 mutations. J Biol Chem 276:2971\u20132974","journal-title":"J Biol Chem"},{"key":"1635_CR5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1086\/346094","volume":"72","author":"X Dong","year":"2003","unstructured":"Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK, Qian C, Marks AF, Slager SL, Peterson BJ, Smith DI, Cheville JC, Blute ML, Jacobsen SJ, Schaid DJ, Tindall DJ, Thibodeau SN, Liu W (2003) Mutations in CHEK2 associated with prostate cancer risk. Am J Hum Genet 72:270\u2013280","journal-title":"Am J Hum Genet"},{"key":"1635_CR6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1086\/341943","volume":"71","author":"P Vahteristo","year":"2002","unstructured":"Vahteristo P, Bartkova J, Eerola H, Syrjakoski K, Ojala S, Kilpivaara O, Tamminen A, Kononen J, Aittomaki K, Heikkila P, Holli K, Blomqvist C, Bartek J, Kallioniemi OP, Nevanlinna H (2002) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Am J Hum Genet 71:432\u2013438","journal-title":"Am J Hum Genet"},{"key":"1635_CR7","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1038\/sj.onc.1204811","volume":"20","author":"J Falck","year":"2001","unstructured":"Falck J, Lukas C, Protopopova M, Lukas J, Selivanova G, Bartek J (2001) Functional impact of concomitant versus alternative defects in the Chk2\u2013p53 tumour suppressor pathway. Oncogene 20:5503\u20135510","journal-title":"Oncogene"},{"key":"1635_CR8","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/35071124","volume":"410","author":"J Falck","year":"2001","unstructured":"Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410:842\u2013847","journal-title":"Nature"},{"key":"1635_CR9","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S1097-2765(02)00527-0","volume":"9","author":"J Li","year":"2002","unstructured":"Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ (2002) Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell 9:1045\u20131054","journal-title":"Mol Cell"},{"key":"1635_CR10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/ijc.20299","volume":"111","author":"O Kilpivaara","year":"2004","unstructured":"Kilpivaara O, Vahteristo P, Falck J, Syrjakoski K, Eerola H, Easton D, Bartkova J, Lukas J, Heikkila P, Aittomaki K, Holli K, Blomqvist C, Kallioniemi OP, Bartek J, Nevanlinna H (2004) CHEK2 variant I157T may be associated with increased breast cancer risk. Int J Cancer 111:543\u2013547","journal-title":"Int J Cancer"},{"key":"1635_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0004.2010.01402.x","volume":"78","author":"SA Narod","year":"2010","unstructured":"Narod SA (2010) Testing for CHEK2 in the cancer genetics clinic: ready for prime time? Clin Genet 78:1\u20137","journal-title":"Clin Genet"},{"key":"1635_CR12","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/426403","volume":"75","author":"C Cybulski","year":"2004","unstructured":"Cybulski C, Gorski B, Huzarski T, Masojc B, Mierzejewski M, Debniak T, Teodorczyk U, Byrski T, Gronwald J, Matyjasik J, Zlowocka E, Lenner M, Grabowska E, Nej K, Castaneda J, Medrek K, Szymanska A, Szymanska J, Kurzawski G, Suchy J, Oszurek O, Witek A, Narod SA, Lubinski J (2004) CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet 75:1131\u20131135","journal-title":"Am J Hum Genet"},{"key":"1635_CR13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10549-004-3778-2","volume":"90","author":"T Huzarski","year":"2005","unstructured":"Huzarski T, Cybulski C, Domagala W, Gronwald J, Byrski T, Szwiec M, Woyke S, Narod SA, Lubinski J (2005) Pathology of breast cancer in women with constitutional CHEK2 mutations. Breast Cancer Res Treat 90:187\u2013189","journal-title":"Breast Cancer Res Treat"},{"key":"1635_CR14","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1158\/1078-0432.CCR-06-0158","volume":"12","author":"C Cybulski","year":"2006","unstructured":"Cybulski C, Gorski B, Huzarski T, Byrski T, Gronwald J, Debniak T, Wokolorczyk D, Jakubowska A, Kowalska E, Oszurek O, Narod SA, Lubinski J (2006) CHEK2-positive breast cancers in young Polish women. Clin Cancer Res 12:4832\u20134835","journal-title":"Clin Cancer Res"},{"key":"1635_CR15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/jmg.2004.019737","volume":"41","author":"GH Bock de","year":"2004","unstructured":"de Bock GH, Schutte M, Krol-Warmerdam EM, Seynaeve C, Blom J, Brekelmans CT, Meijers-Heijboer H, van Asperen CJ, Cornelisse CJ, Devilee P, Tollenaar RA, Klijn JG (2004) Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant. J Med Genet 41:731\u2013735","journal-title":"J Med Genet"},{"key":"1635_CR16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1399-0004.2008.01111.x","volume":"75","author":"C Cybulski","year":"2009","unstructured":"Cybulski C, Huzarski T, Byrski T, Gronwald J, Debniak T, Jakubowska A, Gorski B, Wokolorczyk D, Masojc B, Narod SA, Lubinski J (2009) Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention. Clin Genet 75:72\u201378","journal-title":"Clin Genet"},{"key":"1635_CR17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406:747\u2013752","journal-title":"Nature"},{"key":"1635_CR18","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","volume":"98","author":"T Sorlie","year":"2001","unstructured":"Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lonning P, Borresen-Dale AL (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869\u201310874","journal-title":"Proc Natl Acad Sci USA"},{"key":"1635_CR19","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1001\/jama.295.21.2492","volume":"295","author":"LA Carey","year":"2006","unstructured":"Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, Deming SL, Geradts J, Cheang MC, Nielsen TO, Moorman PG, Earp HS, Millikan RC (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295:2492\u20132502","journal-title":"JAMA"},{"key":"1635_CR20","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1158\/1078-0432.CCR-07-1658","volume":"14","author":"MC Cheang","year":"2008","unstructured":"Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK, Perou CM, Nielsen TO (2008) Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 14:1368\u20131376","journal-title":"Clin Cancer Res"},{"key":"1635_CR21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/PDM.0b013e31818d107b","volume":"18","author":"P Tang","year":"2009","unstructured":"Tang P, Skinner KA, Hicks DG (2009) Molecular classification of breast carcinomas by immunohistochemical analysis: are we ready? Diagn Mol Pathol 18:125\u2013132","journal-title":"Diagn Mol Pathol"},{"key":"1635_CR22","doi-asserted-by":"crossref","first-page":"e1000279","DOI":"10.1371\/journal.pmed.1000279","volume":"7","author":"FM Blows","year":"2010","unstructured":"Blows FM, Driver KE, Schmidt MK, Broeks A, van Leeuwen FE, Wesseling J, Cheang MC, Gelmon K, Nielsen TO, Blomqvist C, Heikkila P, Heikkinen T, Nevanlinna H, Akslen LA, Begin LR, Foulkes WD, Couch FJ, Wang X, Cafourek V, Olson JE, Baglietto L, Giles GG, Severi G, McLean CA, Southey MC, Rakha E, Green AR, Ellis IO, Sherman ME, Lissowska J, Anderson WF, Cox A, Cross SS, Reed MW, Provenzano E, Dawson SJ, Dunning AM, Humphreys M, Easton DF, Garcia-Closas M, Caldas C, Pharoah PD, Huntsman D (2010) Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med 7:e1000279","journal-title":"PLoS Med"},{"key":"1635_CR23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10549-006-9320-y","volume":"102","author":"C Cybulski","year":"2007","unstructured":"Cybulski C, Wokolorczyk D, Huzarski T, Byrski T, Gronwald J, Gorski B, Debniak T, Masojc B, Jakubowska A, van de Wetering T, Narod SA, Lubinski J (2007) A deletion in CHEK2 of 5,395\u00a0bp predisposes to breast cancer in Poland. Breast Cancer Res Treat 102:119\u2013122","journal-title":"Breast Cancer Res Treat"},{"key":"1635_CR24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","volume":"19","author":"CW Elston","year":"1991","unstructured":"Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19:403\u2013410","journal-title":"Histopathology"},{"key":"1635_CR25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00428-010-0988-3","volume":"458","author":"P Domagala","year":"2011","unstructured":"Domagala P, Huzarski T, Lubinski J, Gugala K, Domagala W (2011) Immunophenotypic predictive profiling of BRCA1-associated breast cancer. Virchows Arch 458:55\u201364","journal-title":"Virchows Arch"},{"key":"1635_CR26","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10549-011-1441-2","volume":"127","author":"P Domagala","year":"2011","unstructured":"Domagala P, Huzarski T, Lubinski J, Gugala K, Domagala W (2011) PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: possible implications for PARP-1 inhibitor therapy. Breast Cancer Res Treat 127:861\u2013869","journal-title":"Breast Cancer Res Treat"},{"key":"1635_CR27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3816\/CCC.2002.n.005","volume":"1","author":"GG Chung","year":"2002","unstructured":"Chung GG, Kielhorn EP, Rimm DL (2002) Subjective differences in outcome are seen as a function of the immunohistochemical method used on a colorectal cancer tissue microarray. Clin Colorectal Cancer 1:237\u2013242","journal-title":"Clin Colorectal Cancer"},{"key":"1635_CR28","doi-asserted-by":"crossref","unstructured":"Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL, Hanna WM, Langer A, McShane LM, Paik S, Pegram MD, Perez EA, Press MF, Rhodes A, Sturgeon C, Taube SE, Tubbs R, Vance GH, van de Vijver M, Wheeler TM, Hayes DF, American Society of Clinical Oncology\/College of American Pathologists (2007) American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med 131:18\u201343","DOI":"10.1200\/JCO.2006.09.2775"},{"key":"1635_CR29","doi-asserted-by":"crossref","first-page":"907","DOI":"10.5858\/134.6.907","volume":"134","author":"ME Hammond","year":"2010","unstructured":"Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, Fitzgibbons PL, Francis G, Goldstein NS, Hayes M, Hicks DG, Lester S, Love R, Mangu PB, McShane L, Miller K, Osborne CK, Paik S, Perlmutter J, Rhodes A, Sasano H, Schwartz JN, Sweep FC, Taube S, Torlakovic EE, Valenstein P, Viale G, Visscher D, Wheeler T, Williams RB, Wittliff JL, Wolff AC (2010) American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. Arch Pathol Lab Med 134:907\u2013922","journal-title":"Arch Pathol Lab Med"},{"key":"1635_CR30","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1158\/1078-0432.CCR-04-0220","volume":"10","author":"TO Nielsen","year":"2004","unstructured":"Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM (2004) Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10:5367\u20135374","journal-title":"Clin Cancer Res"},{"key":"1635_CR31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.21004","volume":"116","author":"DM Abd El-Rehim","year":"2005","unstructured":"Abd El-Rehim DM, Ball G, Pinder SE, Rakha E, Paish C, Robertson JF, Macmillan D, Blamey RW, Ellis IO (2005) High-throughput protein expression analysis using tissue microarray technology of a large well-characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses. Int J Cancer 116:340\u2013350","journal-title":"Int J Cancer"},{"key":"1635_CR32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.critrevonc.2007.12.008","volume":"67","author":"V Durbecq","year":"2008","unstructured":"Durbecq V, Ameye L, Veys I, Paesmans M, Desmedt C, Sirtaine N, Sotiriou C, Bernard-Marty C, Nogaret JM, Piccart M, Larsimont D (2008) A significant proportion of elderly patients develop hormone-dependant \u201cluminal-B\u201d tumours associated with aggressive characteristics. Crit Rev Oncol Hematol 67:80\u201392","journal-title":"Crit Rev Oncol Hematol"},{"key":"1635_CR33","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/jnci\/djp082","volume":"101","author":"MC Cheang","year":"2009","unstructured":"Cheang MC, Chia SK, Voduc D, Gao D, Leung S, Snider J, Watson M, Davies S, Bernard PS, Parker JS, Perou CM, Ellis MJ, Nielsen TO (2009) Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer. J Natl Cancer Inst 101:736\u2013750","journal-title":"J Natl Cancer Inst"},{"key":"1635_CR34","first-page":"444","volume":"2","author":"R Bhargava","year":"2009","unstructured":"Bhargava R, Striebel J, Beriwal S, Flickinger JC, Onisko A, Ahrendt G, Dabbs DJ (2009) Prevalence, morphologic features and proliferation indices of breast carcinoma molecular classes using immunohistochemical surrogate markers. Int J Clin Exp Pathol 2:444\u2013455","journal-title":"Int J Clin Exp Pathol"},{"key":"1635_CR35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.molonc.2010.04.001","volume":"4","author":"KA Kwei","year":"2010","unstructured":"Kwei KA, Kung Y, Salari K, Holcomb IN, Pollack JR (2010) Genomic instability in breast cancer: pathogenesis and clinical implications. Mol Oncol 4:255\u2013266","journal-title":"Mol Oncol"},{"key":"1635_CR36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/ijc.20638","volume":"113","author":"O Kilpivaara","year":"2005","unstructured":"Kilpivaara O, Bartkova J, Eerola H, Syrjakoski K, Vahteristo P, Lukas J, Blomqvist C, Holli K, Heikkila P, Sauter G, Kallioniemi OP, Bartek J, Nevanlinna H (2005) Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients. Int J Cancer 113:575\u2013580","journal-title":"Int J Cancer"},{"key":"1635_CR37","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.radonc.2006.12.002","volume":"82","author":"A Meyer","year":"2007","unstructured":"Meyer A, Dork T, Sohn C, Karstens JH, Bremer M (2007) Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy. Radiother Oncol 82:349\u2013353","journal-title":"Radiother Oncol"},{"key":"1635_CR38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1200\/JCO.2006.06.3024","volume":"25","author":"MK Schmidt","year":"2007","unstructured":"Schmidt MK, Tollenaar RA, de Kemp SR, Broeks A, Cornelisse CJ, Smit VT, Peterse JL, van Leeuwen FE, Van\u2019t Veer LJ (2007) Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation. J Clin Oncol 25:64\u201369","journal-title":"J Clin Oncol"},{"key":"1635_CR39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1200\/JCO.2005.05.5160","volume":"25","author":"M Weischer","year":"2007","unstructured":"Weischer M, Bojesen SE, Tybjaerg-Hansen A, Axelsson CK, Nordestgaard BG (2007) Increased risk of breast cancer associated with CHEK2*1100delC. J Clin Oncol 25:57\u201363","journal-title":"J Clin Oncol"},{"key":"1635_CR40","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/1097-0142(19881215)62:12<2517::AID-CNCR2820621211>3.0.CO;2-9","volume":"62","author":"B Chevallier","year":"1988","unstructured":"Chevallier B, Heintzmann F, Mosseri V, Dauce JP, Bastit P, Graic Y, Brunelle P, Basuyau JP, Comoz M, Asselain B (1988) Prognostic value of estrogen and progesterone receptors in operable breast cancer. Results of a univariate and multivariate analysis. Cancer 62:2517\u20132524","journal-title":"Cancer"},{"key":"1635_CR41","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1200\/JCO.2007.12.5922","volume":"26","author":"M Weischer","year":"2008","unstructured":"Weischer M, Bojesen SE, Ellervik C, Tybjaerg-Hansen A, Nordestgaard BG (2008) CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. J Clin Oncol 26:542\u2013548","journal-title":"J Clin Oncol"},{"key":"1635_CR42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1200\/JCO.2007.13.8503","volume":"26","author":"K Offit","year":"2008","unstructured":"Offit K, Garber JE (2008) Time to check CHEK2 in families with breast cancer? J Clin Oncol 26:519\u2013520","journal-title":"J Clin Oncol"},{"key":"1635_CR43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1399-0004.2010.01444.x","volume":"78","author":"M Robson","year":"2010","unstructured":"Robson M (2010) CHEK2, breast cancer, and the understanding of clinical utility. Clin Genet 78:8\u201310","journal-title":"Clin Genet"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-011-1635-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-011-1635-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-011-1635-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T05:46:31Z","timestamp":1637905591000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-011-1635-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,24]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["1635"],"URL":"https:\/\/doi.org\/10.1007\/s10549-011-1635-7","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,24]]}}}