{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:08:00Z","timestamp":1788448080902,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T00:00:00Z","timestamp":1326326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1007\/s10549-012-1953-4","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T10:44:52Z","timestamp":1326278692000},"page":"765-771","source":"Crossref","is-referenced-by-count":33,"title":["Melatonin suppresses aromatase expression and activity in breast cancer associated fibroblasts"],"prefix":"10.1007","volume":"132","author":[{"given":"Kevin C.","family":"Knower","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Q.","family":"To","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan R.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin D.","family":"Clyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,12]]},"reference":[{"issue":"23","key":"1953_CR1","doi-asserted-by":"crossref","first-page":"8948","DOI":"10.1073\/pnas.85.23.8948","volume":"85","author":"CJ Corbin","year":"1988","unstructured":"Corbin CJ, Graham-Lorence S, McPhaul M, Mason JI, Mendelson CR, Simpson ER (1988) Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci USA 85(23):8948\u20138952","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1953_CR2","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/jc.77.6.1622","volume":"77","author":"SE Bulun","year":"1993","unstructured":"Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER (1993) A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab 77(6):1622\u20131628","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"1953_CR3","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1210\/en.137.12.5739","volume":"137","author":"Y Zhao","year":"1996","unstructured":"Zhao Y, Agarwal VR, Mendelson CR, Simpson ER (1996) Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137(12):5739\u20135742","journal-title":"Endocrinology"},{"issue":"11","key":"1953_CR4","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1210\/me.10.11.1350","volume":"10","author":"Y Zhao","year":"1996","unstructured":"Zhao Y, Nichols JE, Valdez R, Mendelson CR, Simpson ER (1996) Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4. Mol Endocrinol 10(11):1350\u20131357","journal-title":"Mol Endocrinol"},{"key":"1953_CR5","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1017\/S1462399409000982","volume":"11","author":"SG Grant","year":"2009","unstructured":"Grant SG, Melan MA, Latimer JJ, Witt-Enderby PA (2009) Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med 11:e5","journal-title":"Expert Rev Mol Med"},{"issue":"3","key":"1953_CR6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-079X.2011.00888.x","volume":"51","author":"DE Blask","year":"2011","unstructured":"Blask DE, Hill SM, Dauchy RT, Xiang S, Yuan L, Duplessis T, Mao L, Dauchy E et al (2011) Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the consequences of its disruption by light at night. J Pineal Res 51(3):259\u2013269","journal-title":"J Pineal Res"},{"issue":"36","key":"1953_CR7","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.2174\/092986710794183015","volume":"17","author":"MD Mediavilla","year":"2010","unstructured":"Mediavilla MD, Sanchez-Barcelo EJ, Tan DX, Manchester L, Reiter RJ (2010) Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem 17(36):4462\u20134481","journal-title":"Curr Med Chem"},{"issue":"Suppl 2","key":"1953_CR8","first-page":"28","volume":"23","author":"VN Anisimov","year":"2002","unstructured":"Anisimov VN (2002) The light\u2013dark regimen and cancer development. Neuro Endocrinol Lett 23(Suppl 2):28\u201336","journal-title":"Neuro Endocrinol Lett"},{"issue":"1","key":"1953_CR9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1158\/1055-9965.EPI-08-0637","volume":"18","author":"ES Schernhammer","year":"2009","unstructured":"Schernhammer ES, Hankinson SE (2009) Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses\u2019 Health Study cohort. Cancer Epidemiol Biomarkers Prev 18(1):74\u201379","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"1953_CR10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/jcem-55-1-27","volume":"55","author":"H Iguichi","year":"1982","unstructured":"Iguichi H, Kato KI, Ibayashi H (1982) Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 55(1):27\u201329","journal-title":"J Clin Endocrinol Metab"},{"issue":"4549","key":"1953_CR11","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1126\/science.7079745","volume":"216","author":"L Tamarkin","year":"1982","unstructured":"Tamarkin L, Danforth D, Lichter A, DeMoss E, Cohen M, Chabner B, Lippman M (1982) Decreased nocturnal plasma melatonin peak in patients with estrogen receptor positive breast cancer. Science 216(4549):1003\u20131005","journal-title":"Science"},{"issue":"1","key":"1953_CR12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10549-010-0958-0","volume":"127","author":"SM Hill","year":"2011","unstructured":"Hill SM, Cheng C, Yuan L, Mao L, Jockers R, Dauchy B, Frasch T, Blask DE (2011) Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin. Breast Cancer Res Treat 127(1):91\u201398","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"1953_CR13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-079X.2004.00186.x","volume":"38","author":"S Cos","year":"2005","unstructured":"Cos S, Martinez-Campa C, Mediavilla MD, Sanchez-Barcelo EJ (2005) Melatonin modulates aromatase activity in MCF-7 human breast cancer cells. J Pineal Res 38(2):136\u2013142","journal-title":"J Pineal Res"},{"issue":"9","key":"1953_CR14","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.bjc.6605336","volume":"101","author":"C Martinez-Campa","year":"2009","unstructured":"Martinez-Campa C, Gonzalez A, Mediavilla MD, Alonso-Gonzalez C, Alvarez-Garcia V, Sanchez-Barcelo EJ, Cos S (2009) Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. Br J Cancer 101(9):1613\u20131619","journal-title":"Br J Cancer"},{"issue":"1","key":"1953_CR15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1677\/ERC-07-0092","volume":"15","author":"R Shibuya","year":"2008","unstructured":"Shibuya R, Suzuki T, Miki Y, Yoshida K, Moriya T, Ono K, Akahira J, Ishida T et al (2008) Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast. Endocr Relat Cancer 15(1):113\u2013124","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"1953_CR16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1210\/jcem-53-2-412","volume":"53","author":"GE Ackerman","year":"1981","unstructured":"Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER (1981) Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab 53(2):412\u2013417","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1953_CR17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-079X.2008.00559.x","volume":"45","author":"A Gonzalez","year":"2008","unstructured":"Gonzalez A, Cos S, Martinez-Campa C, Alonso-Gonzalez C, Sanchez-Mateos S, Mediavilla MD, Sanchez-Barcelo EJ (2008) Selective estrogen enzyme modulator actions of melatonin in human breast cancer cells. J Pineal Res 45(1):86\u201392","journal-title":"J Pineal Res"},{"issue":"4","key":"1953_CR18","first-page":"947","volume":"17","author":"A Gonzalez","year":"2007","unstructured":"Gonzalez A, Martinez-Campa C, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Mateos S, Hill SM, Sanchez-Barcelo EJ, Cos S (2007) Effects of MT1 melatonin receptor overexpression on the aromatase-suppressive effect of melatonin in MCF-7 human breast cancer cells. Oncol Rep 17(4):947\u2013953","journal-title":"Oncol Rep"},{"issue":"1","key":"1953_CR19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2008.05.038","volume":"273","author":"D Chen","year":"2009","unstructured":"Chen D, Reierstad S, Lu M, Lin Z, Ishikawa H, Bulun SE (2009) Regulation of breast cancer-associated aromatase promoters. Cancer Lett 273(1):15\u201327","journal-title":"Cancer Lett"},{"issue":"1\u20135","key":"1953_CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jsbmb.2005.04.002","volume":"95","author":"S Chen","year":"2005","unstructured":"Chen S, Ye J, Kijima I, Kinoshita Y, Zhou D (2005) Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. J Steroid Biochem Mol Biol 95(1\u20135):17\u201323","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"1953_CR21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-079X.2004.00198.x","volume":"38","author":"TL Kiefer","year":"2005","unstructured":"Kiefer TL, Lai L, Yuan L, Dong C, Burow ME, Hill SM (2005) Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. J Pineal Res 38(4):231\u2013239","journal-title":"J Pineal Res"},{"issue":"2","key":"1953_CR22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-079X.2010.00821.x","volume":"50","author":"G Negi","year":"2011","unstructured":"Negi G, Kumar A, Sharma SS (2011) Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades. J Pineal Res 50(2):124\u2013131","journal-title":"J Pineal Res"},{"key":"1953_CR23","doi-asserted-by":"crossref","unstructured":"Gonzalez A, Alvarez-Garcia V, Martinez-Campa C, Alonso-Gonzalez C, Cos S (2011) Melatonin promotes differentiation of 3T3-L1 fibroblasts. J Pineal Res","DOI":"10.1111\/j.1600-079X.2011.00911.x"},{"issue":"3","key":"1953_CR24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10549-005-9006-x","volume":"94","author":"C Martinez-Campa","year":"2005","unstructured":"Martinez-Campa C, Gonzalez A, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Barcelo EJ, Cos S (2005) Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells. Breast Cancer Res Treat 94(3):249\u2013254","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"1953_CR25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ijc.21401","volume":"118","author":"S Cos","year":"2006","unstructured":"Cos S, Gonzalez A, Guezmes A, Mediavilla MD, Martinez-Campa C, Alonso-Gonzalez C, Sanchez-Barcelo EJ (2006) Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity. Int J Cancer 118(2):274\u2013278","journal-title":"Int J Cancer"},{"issue":"2","key":"1953_CR26","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10549-010-0834-y","volume":"123","author":"KA Brown","year":"2010","unstructured":"Brown KA, Hunger NI, Docanto M, Simpson ER (2010) Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase. Breast Cancer Res Treat 123(2):591\u2013596","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"1953_CR27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/cc.9.1.10407","volume":"9","author":"VN Anisimov","year":"2010","unstructured":"Anisimov VN, Egormin PA, Piskunova TS, Popovich IG, Tyndyk ML, Yurova MN, Zabezhinski MA, Anikin IV et al (2010) Metformin extends life span of HER-2\/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle 9(1):188\u2013197","journal-title":"Cell Cycle"},{"issue":"8","key":"1953_CR28","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0046-8177(95)90010-1","volume":"26","author":"P Robbins","year":"1995","unstructured":"Robbins P, Pinder S, de Klerk N, Dawkins H, Harvey J, Sterrett G, Ellis I, Elston C (1995) Histological grading of breast carcinomas: a study of interobserver agreement. Hum Pathol 26(8):873\u2013879","journal-title":"Hum Pathol"},{"issue":"2","key":"1953_CR29","first-page":"155","volume":"11","author":"DC Allred","year":"1998","unstructured":"Allred DC, Harvey JM, Berardo M, Clark GM (1998) Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 11(2):155\u2013168","journal-title":"Mod Pathol"},{"issue":"1","key":"1953_CR30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5858\/2007-131-18-ASOCCO","volume":"131","author":"AC Wolff","year":"2007","unstructured":"Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL et al (2007) American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med 131(1):18\u201343","journal-title":"Arch Pathol Lab Med"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-012-1953-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-012-1953-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-012-1953-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T15:12:39Z","timestamp":1713366759000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-012-1953-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,12]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["1953"],"URL":"https:\/\/doi.org\/10.1007\/s10549-012-1953-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,12]]}}}