{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:56:14Z","timestamp":1790776574150,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s10549-014-2944-4","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T09:33:32Z","timestamp":1397036012000},"page":"381-388","source":"Crossref","is-referenced-by-count":115,"title":["A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes"],"prefix":"10.1007","volume":"145","author":[{"given":"Wendy Y.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Giobbie-Hurder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Gantman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Savoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Scheib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy M.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva S.","family":"Schernhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"issue":"6","key":"2944_CR1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.smrv.2006.03.005","volume":"10","author":"L Fiorentino","year":"2006","unstructured":"Fiorentino L, Ancoli-Israel S (2006) Insomnia and its treatment in women with breast cancer. Sleep Med Rev 10(6):419\u2013429","journal-title":"Sleep Med Rev"},{"issue":"7538","key":"2944_CR2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/bmj.38731.532766.F6","volume":"332","author":"N Buscemi","year":"2006","unstructured":"Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, Vohra S, Klassen TP, Baker G (2006) Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 332(7538):385\u2013393","journal-title":"BMJ"},{"key":"2944_CR3","doi-asserted-by":"crossref","unstructured":"Herxheimer A, Petrie KJ (2002) Melatonin for the prevention and treatment of jet lag. Cochrane Database of Systematic Reviews","DOI":"10.1002\/14651858.CD001520"},{"issue":"4","key":"2944_CR4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1600-079X.2011.00962.x","volume":"52","author":"DP Cardinali","year":"2012","unstructured":"Cardinali DP, Srinivasan V, Brzezinski A, Brown GM (2012) Melatonin and its analogs in insomnia and depression. J Pineal Res 52(4):365\u2013375","journal-title":"J Pineal Res"},{"issue":"2","key":"2944_CR5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0531-5565(00)00217-5","volume":"36","author":"G Bellipanni","year":"2001","unstructured":"Bellipanni G, Bianchi P, Pierpaoli W, Bulian D, Ilyia E (2001) Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp Gerontol 36(2):297\u2013310","journal-title":"Exp Gerontol"},{"issue":"1","key":"2944_CR6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/jcem-55-1-27","volume":"55","author":"H Iguichi","year":"1982","unstructured":"Iguichi H, Kato KI, Ibayashi H (1982) Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab 55(1):27\u201329","journal-title":"J Clin Endocrinol Metab"},{"issue":"20","key":"2944_CR7","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1158\/0008-5472.CAN-06-1776","volume":"66","author":"B Jung","year":"2006","unstructured":"Jung B, Ahmad N (2006) Melatonin in cancer management: progress and promise. Cancer Res 66(20):9789\u20139793","journal-title":"Cancer Res"},{"issue":"4","key":"2944_CR8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1600-079X.2005.00258.x","volume":"39","author":"E Mills","year":"2005","unstructured":"Mills E, Wu P, Seely D, Guyatt G (2005) Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 39(4):360\u2013366","journal-title":"J Pineal Res"},{"issue":"4","key":"2944_CR9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10552-012-9927-8","volume":"23","author":"ES Schernhammer","year":"2012","unstructured":"Schernhammer ES, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, Chen WY (2012) A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control 23(4):609\u2013616","journal-title":"Cancer Causes Control"},{"issue":"2","key":"2944_CR10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatr Res 28(2):193\u2013213","journal-title":"Psychiatr Res"},{"issue":"5","key":"2944_CR11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-3999(99)00004-5","volume":"46","author":"D Hann","year":"1999","unstructured":"Hann D, Winter K, Jacobsen P (1999) Measurement of depressive symptoms in cancer patients: evaluation of the Center for Epidemiological Studies Depression Scale (CES-D). J Psychosom Res 46(5):437\u2013443","journal-title":"J Psychosom Res"},{"key":"2944_CR12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","volume":"1","author":"LS Radloff","year":"1977","unstructured":"Radloff LS (1977) The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Measure 1:385\u2013401","journal-title":"Appl Psychol Measure"},{"issue":"23","key":"2944_CR13","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1200\/JCO.2001.19.23.4280","volume":"19","author":"JA Sloan","year":"2001","unstructured":"Sloan JA, Loprinzi CL, Novotny PJ, Barton DL, Lavasseur BI, Windschitl H (2001) Methodologic lessons learned from hot flash studies. J Clin Oncol 19(23):4280\u20134290","journal-title":"J Clin Oncol"},{"issue":"6","key":"2944_CR14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1158\/1055-9965.EPI-12-0075","volume":"21","author":"KS Courneya","year":"2012","unstructured":"Courneya KS, Sellar CM, Trinh L, Forbes CC, Stevinson C, McNeely ML, Peddle-McIntyre CJ, Friedenreich CM, Reiman T (2012) A randomized trial of aerobic exercise and sleep quality in lymphoma patients receiving chemotherapy or no treatments. Cancer Epidemiol Biomarkers Prev 21(6):887\u2013894","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"2944_CR15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1188\/08.ONF.635-642","volume":"35","author":"JK Payne","year":"2008","unstructured":"Payne JK, Held J, Thorpe J, Shaw H (2008) Effect of exercise on biomarkers, fatigue, sleep disturbances, and depressive symptoms in older women with breast cancer receiving hormonal therapy. Oncol Nurs Forum 35(4):635\u2013642","journal-title":"Oncol Nurs Forum"},{"issue":"9","key":"2944_CR16","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1089\/jwh.2008.1257","volume":"18","author":"ME Yurcheshen","year":"2009","unstructured":"Yurcheshen ME, Guttuso T Jr, McDermott M, Holloway RG, Perlis M (2009) Effects of gabapentin on sleep in menopausal women with hot flashes as measured by a Pittsburgh Sleep Quality Index factor scoring model. J Womens Health (Larchmt) 18(9):1355\u20131360","journal-title":"J Womens Health (Larchmt)"},{"issue":"12","key":"2944_CR17","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/sleep\/33.12.1605","volume":"33","author":"IM Geijlswijk van","year":"2010","unstructured":"van Geijlswijk IM, Korzilius HP, Smits MG (2010) The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 33(12):1605\u20131614","journal-title":"Sleep"},{"issue":"1","key":"2944_CR18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10549-011-1530-2","volume":"130","author":"CM Alfano","year":"2011","unstructured":"Alfano CM, Lichstein KL, Vander Wal GS, Smith AW, Reeve BB, Mc Tiernan A, Bernstein L, Baumgartner KB, Ballard-Barbash R (2011) Sleep duration change across breast cancer survivorship: associations with symptoms and health-related quality of life. Breast Cancer Res Treat 130(1):243\u2013254","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"2944_CR19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jpainsymman.2009.07.004","volume":"39","author":"JL Otte","year":"2010","unstructured":"Otte JL, Carpenter JS, Russell KM, Bigatti S, Champion VL (2010) Prevalence, severity, and correlates of sleep-wake disturbances in long-term breast cancer survivors. J Pain Symptom Manage 39(3):535\u2013547","journal-title":"J Pain Symptom Manage"},{"issue":"35","key":"2944_CR20","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1200\/JCO.2008.20.8306","volume":"27","author":"AM Berger","year":"2009","unstructured":"Berger AM, Kuhn BR, Farr LA, Von Essen SG, Chamberlain J, Lynch JC, Agrawal S (2009) One-year outcomes of a behavioral therapy intervention trial on sleep quality and cancer-related fatigue. J Clin Oncol 27(35):6033\u20136040","journal-title":"J Clin Oncol"},{"issue":"5","key":"2944_CR21","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1188\/07.ONF.E51-E59","volume":"34","author":"DR Epstein","year":"2007","unstructured":"Epstein DR, Dirksen SR (2007) Randomized trial of a cognitive-behavioral intervention for insomnia in breast cancer survivors. Oncol Nurs Forum 34(5):E51\u2013E59","journal-title":"Oncol Nurs Forum"},{"issue":"25","key":"2944_CR22","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1200\/JCO.2005.12.513","volume":"23","author":"J Savard","year":"2005","unstructured":"Savard J, Simard S, Ivers H, Morin CM (2005) Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part II: immunologic effects. J Clin Oncol 23(25):6097\u20136106","journal-title":"J Clin Oncol"},{"issue":"1","key":"2944_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-5122(03)00219-6","volume":"47","author":"G Secreto","year":"2004","unstructured":"Secreto G, Chiechi LM, Amadori A, Miceli R, Venturelli E, Valerio T, Marubini E (2004) Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 47(1):11\u201320","journal-title":"Maturitas"},{"issue":"4","key":"2944_CR24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1600-079X.2011.00956.x","volume":"52","author":"MP Kotlarczyk","year":"2012","unstructured":"Kotlarczyk MP, Lassila HC, O\u2019Neil CK, D\u2019Amico F, Enderby LT, Witt-Enderby PA, Balk JL (2012) Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J Pineal Res 52(4):414\u2013426","journal-title":"J Pineal Res"},{"issue":"9791","key":"2944_CR25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(11)60095-0","volume":"378","author":"IB Hickie","year":"2011","unstructured":"Hickie IB, Rogers NL (2011) Novel melatonin-based therapies: potential advances in the treatment of major depression. Lancet 378(9791):621\u2013631","journal-title":"Lancet"},{"issue":"12","key":"2944_CR26","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/S0959-8049(99)00159-8","volume":"35","author":"P Lissoni","year":"1999","unstructured":"Lissoni P, Barni S, Mandala M, Ardizzoia A, Paolorossi F, Vaghi M, Longarini R, Malugani F, Tancini G (1999) Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer 35(12):1688\u20131692","journal-title":"Eur J Cancer"},{"issue":"4","key":"2944_CR27","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/bjc.1995.164","volume":"71","author":"P Lissoni","year":"1995","unstructured":"Lissoni P, Barni S, Meregalli S, Fossati V, Cazzaniga M, Esposti D, Tancini G (1995) Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. Br J Cancer 71(4):854\u2013856","journal-title":"Br J Cancer"},{"issue":"1","key":"2944_CR28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1034\/j.1600-079X.2003.00032.x","volume":"35","author":"P Lissoni","year":"2003","unstructured":"Lissoni P, Chilelli M, Villa S, Cerizza L, Tancini G (2003) Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J Pineal Res 35(1):12\u201315","journal-title":"J Pineal Res"},{"issue":"1","key":"2944_CR29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-079X.1997.tb00329.x","volume":"23","author":"P Lissoni","year":"1997","unstructured":"Lissoni P, Paolorossi F, Ardizzoia A, Barni S, Chilelli M, Mancuso M, Tancini G, Conti A, Maestroni GJ (1997) A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J Pineal Res 23(1):15\u201319","journal-title":"J Pineal Res"},{"issue":"3","key":"2944_CR30","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1309\/1T4V-CT1G-UBJP-3EHP","volume":"118","author":"DC Dillon","year":"2002","unstructured":"Dillon DC, Easley SE, Asch BB, Cheney RT, Brydon L, Jockers R, Winston JS, Brooks JS, Hurd T, Asch HL (2002) Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue. Am J Clin Pathol 118(3):451\u2013458","journal-title":"Am J Clin Pathol"},{"key":"2944_CR31","first-page":"4383","volume":"58","author":"S Cos","year":"1998","unstructured":"Cos S, Fernandez R, Guezmes A, Sanchez-Barcelo EJ (1998) Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 58:4383\u20134390","journal-title":"Cancer Res"},{"issue":"2","key":"2944_CR32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/frne.1999.0194","volume":"21","author":"S Cos","year":"2000","unstructured":"Cos S, Sanchez-Barcelo EJ (2000) Melatonin and mammary pathological growth. Front Neuroendocrinol 21(2):133\u2013170","journal-title":"Front Neuroendocrinol"},{"key":"2944_CR33","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1017\/S1462399409000982","volume":"11","author":"SG Grant","year":"2009","unstructured":"Grant SG, Melan MA, Latimer JJ, Witt-Enderby PA (2009) Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med 11:e5","journal-title":"Expert Rev Mol Med"},{"issue":"4","key":"2944_CR34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1600-079X.2004.00207.x","volume":"38","author":"EJ Sanchez-Barcelo","year":"2005","unstructured":"Sanchez-Barcelo EJ, Cos S, Mediavilla D, Martinez-Campa C, Gonzalez A, Alonso-Gonzalez C (2005) Melatonin\u2013estrogen interactions in breast cancer. J Pineal Res 38(4):217\u2013222","journal-title":"J Pineal Res"},{"issue":"3","key":"2944_CR35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/jpi.12032","volume":"54","author":"K Jablonska","year":"2013","unstructured":"Jablonska K, Pula B, Zemla A, Owczarek T, Wojnar A, Rys J, Ambicka A, Podhorska-Okolow M, Ugorski M, Dziegiel P (2013) Expression of melatonin receptor MT1 in cells of human invasive ductal breast carcinoma. J Pineal Res 54(3):334\u2013345","journal-title":"J Pineal Res"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-014-2944-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-014-2944-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-014-2944-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T06:35:49Z","timestamp":1565332549000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-014-2944-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["2944"],"URL":"https:\/\/doi.org\/10.1007\/s10549-014-2944-4","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718346160.793496340","asserted-by":"object"}]},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,10]]}}}