{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:39:56Z","timestamp":1785544796115,"version":"3.56.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["703058"],"award-info":[{"award-number":["703058"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RC4CA153828"],"award-info":[{"award-number":["RC4CA153828"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA74415"],"award-info":[{"award-number":["R01CA74415"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s10549-016-3685-3","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T06:40:07Z","timestamp":1452926407000},"page":"365-373","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case\u2013control study"],"prefix":"10.1007","volume":"155","author":[{"given":"Joanne","family":"Kotsopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Huzarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Moller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigha","family":"Senter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle","family":"Demsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Karlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,16]]},"reference":[{"issue":"9084","key":"3685_CR1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S0140-6736(97)08233-0","volume":"350","author":"Collaborative Group on Hormonal Factors in Breast Cancer","year":"1997","unstructured":"Collaborative Group on Hormonal Factors in Breast Cancer (1997) Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350(9084):1047\u20131059","journal-title":"Lancet"},{"issue":"3","key":"3685_CR2","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jama.288.3.321","volume":"288","author":"JE Rossouw","year":"2002","unstructured":"Rossouw JE et al (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women\u2019s Health Initiative randomized controlled trial. JAMA 288(3):321\u2013333","journal-title":"JAMA"},{"issue":"9382","key":"3685_CR3","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0140-6736(03)14065-2","volume":"362","author":"V Beral","year":"2003","unstructured":"Beral V (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362(9382):419\u2013427","journal-title":"Lancet"},{"issue":"7","key":"3685_CR4","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1002\/cncr.20499","volume":"101","author":"WY Chen","year":"2004","unstructured":"Chen WY et al (2004) Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma. Cancer 101(7):1490\u20131500","journal-title":"Cancer"},{"issue":"4","key":"3685_CR5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/jnci\/djq527","volume":"103","author":"V Beral","year":"2011","unstructured":"Beral V et al (2011) Breast cancer risk in relation to the interval between menopause and starting hormone therapy. J Natl Cancer Inst 103(4):296\u2013305","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"3685_CR6","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrclinonc.2011.110","volume":"8","author":"SA Narod","year":"2011","unstructured":"Narod SA (2011) Hormone replacement therapy and the risk of breast cancer. Nat Rev Clin Oncol 8(11):669\u2013676","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"3685_CR7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/jnci\/djt043","volume":"105","author":"RT Chlebowski","year":"2013","unstructured":"Chlebowski RT et al (2013) Estrogen plus progestin and breast cancer incidence and mortality in the Women\u2019s Health Initiative Observational Study. J Natl Cancer Inst 105(8):26\u201335","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"3685_CR8","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/S1470-2045(12)70075-X","volume":"13","author":"GL Anderson","year":"2012","unstructured":"Anderson GL et al (2012) Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women\u2019s Health Initiative randomised placebo-controlled trial. Lancet Oncol 13(5):476\u2013486","journal-title":"Lancet Oncol"},{"issue":"11","key":"3685_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/S1470-2045(06)70911-1","volume":"7","author":"GK Reeves","year":"2006","unstructured":"Reeves GK et al (2006) Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis. Lancet Oncol 7(11):910\u2013918","journal-title":"Lancet Oncol"},{"issue":"6","key":"3685_CR10","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/bcr2790","volume":"12","author":"J Kotsopoulos","year":"2010","unstructured":"Kotsopoulos J et al (2010) Risk factors for ductal and lobular breast cancer: results from the nurses\u2019 health study. Breast Cancer Res 12(6):R106","journal-title":"Breast Cancer Res"},{"issue":"33","key":"3685_CR11","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1200\/JCO.2006.08.6504","volume":"24","author":"CA Clarke","year":"2006","unstructured":"Clarke CA et al (2006) Recent declines in hormone therapy utilization and breast cancer incidence: clinical and population-based evidence. J Clin Oncol 24(33):e49\u2013e50","journal-title":"J Clin Oncol"},{"issue":"6","key":"3685_CR12","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1158\/1055-9965.EPI-08-1082","volume":"18","author":"CR Eheman","year":"2009","unstructured":"Eheman CR et al (2009) The changing incidence of in situ and invasive ductal and lobular breast carcinomas: United States, 1999\u20132004. Cancer Epidemiol Biomarkers Prev 18(6):1763\u20131769","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9639","key":"3685_CR13","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/S0140-6736(08)61255-6","volume":"372","author":"M Kumle","year":"2008","unstructured":"Kumle M (2008) Declining breast cancer incidence and decreased HRT use. Lancet 372(9639):608\u2013610","journal-title":"Lancet"},{"issue":"19","key":"3685_CR14","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1093\/jnci\/djn313","volume":"100","author":"A Eisen","year":"2008","unstructured":"Eisen A et al (2008) Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers. J Natl Cancer Inst 100(19):1361\u20131367","journal-title":"J Natl Cancer Inst"},{"issue":"31","key":"3685_CR15","doi-asserted-by":"publisher","first-page":"7804","DOI":"10.1200\/JCO.2004.00.8151","volume":"23","author":"TR Rebbeck","year":"2005","unstructured":"Rebbeck TR et al (2005) Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group. J Clin Oncol 23(31):7804\u20137810","journal-title":"J Clin Oncol"},{"issue":"5","key":"3685_CR16","doi-asserted-by":"publisher","first-page":"djv033","DOI":"10.1093\/jnci\/djv033","volume":"107","author":"BA Heemskerk-Gerritsen","year":"2015","unstructured":"Heemskerk-Gerritsen BA et al (2015) Breast cancer risk after salpingo-oophorectomy in healthy BRCA1\/2 mutation carriers: revisiting the evidence for risk reduction. J Natl Cancer Inst 107(5):djv033","journal-title":"J Natl Cancer Inst"},{"issue":"15","key":"3685_CR17","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1200\/JCO.2013.53.2820","volume":"32","author":"AP Finch","year":"2014","unstructured":"Finch AP et al (2014) Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol 32(15):1547\u20131553","journal-title":"J Clin Oncol"},{"issue":"9","key":"3685_CR18","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1002\/ijc.23340","volume":"122","author":"KA Metcalfe","year":"2008","unstructured":"Metcalfe KA et al (2008) International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer 122(9):2017\u20132022","journal-title":"Int J Cancer"},{"issue":"5","key":"3685_CR19","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2217\/whe.12.41","volume":"8","author":"A Finch","year":"2012","unstructured":"Finch A, Evans G, Narod SA (2012) BRCA carriers, prophylactic salpingo-oophorectomy and menopause: clinical management considerations and recommendations. Women\u2019s Health 8(5):543\u2013555","journal-title":"Women\u2019s Health"},{"issue":"3","key":"3685_CR20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s10549-013-2823-4","volume":"143","author":"J Kotsopoulos","year":"2014","unstructured":"Kotsopoulos J et al (2014) Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers. Breast Cancer Res Treat 143(3):579\u2013586","journal-title":"Breast Cancer Res Treat"},{"issue":"12","key":"3685_CR21","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/S1470-2045(13)70448-0","volume":"14","author":"M Widschwendter","year":"2013","unstructured":"Widschwendter M et al (2013) The sex hormone system in carriers of BRCA1\/2 mutations: a case-control study. Lancet Oncol 14(12):1226\u20131232","journal-title":"Lancet Oncol"},{"issue":"15","key":"3685_CR22","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1200\/JCO.2013.53.2820","volume":"32","author":"AP Finch","year":"2014","unstructured":"Finch AP et al (2014) Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation. J Clin Oncol 32(15):1547\u20131553","journal-title":"J Clin Oncol"},{"issue":"9382","key":"3685_CR23","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0140-6736(03)14065-2","volume":"362","author":"V Beral","year":"2003","unstructured":"Beral V, Million C (2003) Women Study, Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362(9382):419\u2013427","journal-title":"Lancet"},{"issue":"1","key":"3685_CR24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.epirev.a036102","volume":"15","author":"MC Pike","year":"1993","unstructured":"Pike MC et al (1993) Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 15(1):17\u201335","journal-title":"Epidemiol Rev"},{"issue":"15","key":"3685_CR25","doi-asserted-by":"publisher","first-page":"5774","DOI":"10.1073\/pnas.0706216105","volume":"105","author":"KB Horwitz","year":"2008","unstructured":"Horwitz KB et al (2008) Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci USA 105(15):5774\u20135779","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"3685_CR26","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1210\/jc.2008-0938","volume":"93","author":"KB Horwitz","year":"2008","unstructured":"Horwitz KB, Sartorius CA (2008) Progestins in hormone replacement therapies reactivate cancer stem cells in women with preexisting breast cancers: a hypothesis. J Clin Endocrinol Metab 93(9):3295\u20133298","journal-title":"J Clin Endocrinol Metab"},{"issue":"7320","key":"3685_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature09495","volume":"468","author":"E Gonzalez-Suarez","year":"2010","unstructured":"Gonzalez-Suarez E et al (2010) RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis. Nature 468(7320):103\u2013107","journal-title":"Nature"},{"issue":"7320","key":"3685_CR28","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature09387","volume":"468","author":"D Schramek","year":"2010","unstructured":"Schramek D et al (2010) Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 468(7320):98\u2013102","journal-title":"Nature"},{"issue":"7299","key":"3685_CR29","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nature09091","volume":"465","author":"PA Joshi","year":"2010","unstructured":"Joshi PA et al (2010) Progesterone induces adult mammary stem cell expansion. Nature 465(7299):803\u2013807","journal-title":"Nature"},{"issue":"1","key":"3685_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.stemcr.2015.05.012","volume":"5","author":"PA Joshi","year":"2015","unstructured":"Joshi PA et al (2015) RANK signaling amplifies WNT-responsive mammary progenitors through R-SPONDIN1. Stem Cell Rep 5(1):31\u201344","journal-title":"Stem Cell Rep"},{"issue":"1","key":"3685_CR31","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1158\/1055-9965.EPI-11-0775","volume":"21","author":"N Mavaddat","year":"2012","unstructured":"Mavaddat N et al (2012) Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the consortium of investigators of modifiers of BRCA1\/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 21(1):134\u2013147","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"3685_CR32","doi-asserted-by":"publisher","first-page":"R833","DOI":"10.1186\/bcr1293","volume":"7","author":"J Kotsopoulos","year":"2005","unstructured":"Kotsopoulos J et al (2005) Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 7(5):R833\u2013R843","journal-title":"Breast Cancer Res"},{"issue":"6","key":"3685_CR33","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10552-005-1724-1","volume":"16","author":"J Kotsopoulos","year":"2005","unstructured":"Kotsopoulos J et al (2005) Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer Causes Control 16(6):667\u2013674","journal-title":"Cancer Causes Control"},{"issue":"12","key":"3685_CR34","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.jclinepi.2007.02.013","volume":"60","author":"S Kropp","year":"2007","unstructured":"Kropp S et al (2007) Good agreement between physician and self-reported hormone therapy data in a case-control study. J Clin Epidemiol 60(12):1280\u20131287","journal-title":"J Clin Epidemiol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3685-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-016-3685-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3685-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3685-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T09:11:17Z","timestamp":1589706677000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-016-3685-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["3685"],"URL":"https:\/\/doi.org\/10.1007\/s10549-016-3685-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726083267.793513623","asserted-by":"object"}]},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"6 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standard"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}