{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:08:04Z","timestamp":1790485684669,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30-CA046592"],"award-info":[{"award-number":["P30-CA046592"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s10549-016-3846-4","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T08:27:41Z","timestamp":1465201661000},"page":"597-603","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations between metabolic syndrome, breast cancer recurrence, and the 21-gene recurrence score assay"],"prefix":"10.1007","volume":"157","author":[{"given":"Jeanette","family":"Muniz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Kidwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Lynn","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,6]]},"reference":[{"key":"3846_CR1","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1056\/NEJMoa1510764","volume":"373","author":"JA Sparano","year":"2015","unstructured":"Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE, Dees EC, Perez EA, Olson JA, Zujewski J, Lively T, Badve SS, Saphner TJ, Wagner LI, Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin P, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Atkins JN, Berenberg JL, Sledge GW (2015) Prospective validation of a 21-gene expression assay in breast cancer. N Engl J Med 373:2005\u20132014. doi:\n                    10.1056\/NEJMoa1510764","journal-title":"N Engl J Med"},{"key":"3846_CR2","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1056\/NEJMoa041588","volume":"351","author":"S Paik","year":"2004","unstructured":"Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817\u20132826","journal-title":"N Engl J Med"},{"key":"3846_CR3","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1200\/JCO.2005.04.7985","volume":"24","author":"S Paik","year":"2006","unstructured":"Paik S, Tang G, Shak S, Kim C, Baker J, Kim W, Cronin M, Baehner FL, Watson D, Bryant J, Costantino JP, Geyer CE Jr, Wickerham DL, Wolmark N (2006) Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J Clin Oncol 24:3726\u20133734","journal-title":"J Clin Oncol"},{"key":"3846_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1470-2045(09)70314-6","volume":"11","author":"KS Albain","year":"2010","unstructured":"Albain KS, Barlow WE, Shak S, Hortobagyi GN, Livingston RB, Yeh IT, Ravdin P, Bugarini R, Baehner FL, Davidson NE, Sledge GW, Winer EP, Hudis C, Ingle JN, Perez EA, Pritchard KI, Shepherd L, Gralow JR, Yoshizawa C, Allred DC, Osborne CK, Hayes DF (2010) Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol 11:55\u201365. doi:\n                    10.1016\/S1470-2045(09)70314-6","journal-title":"Lancet Oncol"},{"key":"3846_CR5","doi-asserted-by":"crossref","unstructured":"Lakhani A, Guo A, Duan X, Ersahin C, Gaynor ER, Godellas C, Kay C, Lo SS, Mai H, Perez C, Albain K, Robinson P (2012) Metabolic syndrome and recurrence within the 21-gene recurrence score assay risk categories in lymph node negative breast cancer. Cancer Res 72(24 Supplement):Abstract PD10-02","DOI":"10.1158\/0008-5472.SABCS12-PD10-02"},{"key":"3846_CR6","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jbi.2015.05.003","volume":"55","author":"DA Hanauer","year":"2015","unstructured":"Hanauer DA, Mei Q, Law J, Khanna R, Zheng K (2015) Supporting information retrieval from electronic health records: a report of University of Michigan\u2019s nine-year experience in developing and using the Electronic Medical Record Search Engine (EMERSE). J Biomed Inform 55:290\u2013300. doi:\n                    10.1016\/j.jbi.2015.05.003","journal-title":"J Biomed Inform"},{"key":"3846_CR7","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1001\/jama.285.19.2486","volume":"106","author":"National Cholesterol Education Program","year":"2002","unstructured":"National Cholesterol Education Program (2002) Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106:3143\u20133421. doi:\n                    10.1001\/jama.285.19.2486","journal-title":"Circulation"},{"key":"3846_CR8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10549-010-0990-0","volume":"123","author":"M Protani","year":"2010","unstructured":"Protani M, Coory M, Martin JH (2010) Effect of obesity on survival of women with breast cancer: systematic review and meta-analysis. Breast Cancer Res Treat 123:627\u2013635. doi:\n                    10.1007\/s10549-010-0990-0","journal-title":"Breast Cancer Res Treat"},{"key":"3846_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1200\/JCO.2011.39.7877","volume":"30","author":"RT Chlebowski","year":"2012","unstructured":"Chlebowski RT (2012) Obesity and breast cancer outcome: adding to the evidence. J Clin Oncol 30:126\u2013128. doi:\n                    10.1200\/JCO.2011.39.7877","journal-title":"J Clin Oncol"},{"key":"3846_CR10","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1200\/JCO.2012.42.5496","volume":"30","author":"JA Ligibel","year":"2012","unstructured":"Ligibel JA, Goodwin PJ (2012) NEW and RENEW: building the case for weight loss in breast cancer. J Clin Oncol 30:2294\u20132296. doi:\n                    10.1200\/JCO.2012.42.5496","journal-title":"J Clin Oncol"},{"key":"3846_CR11","doi-asserted-by":"publisher","first-page":"e41380","DOI":"10.1371\/journal.pone.0041380","volume":"7","author":"S Chen","year":"2012","unstructured":"Chen S, Chen CM, Zhou Y, Zhou RJ, Yu KD, Shao ZM (2012) Obesity or overweight is associated with worse pathological response to neoadjuvant chemotherapy among Chinese women with breast cancer. PLoS One 7:e41380. doi:\n                    10.1371\/journal.pone.0041380","journal-title":"PLoS One"},{"key":"3846_CR12","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.1200\/JCO.2011.40.8666","volume":"30","author":"M Ewertz","year":"2012","unstructured":"Ewertz M, Gray KP, Regan MM, Ejlertsen B, Price KN, Th\u00fcrlimann B, Bonnefoi H, Forbes JF, Paridaens RJ, Rabaglio M, Gelber RD, Colleoni M, L\u00e1ng I, Smith IE, Coates AS, Goldhirsch A, Mouridsen HT (2012) Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the Breast International Group 1\u201398 trial. J Clin Oncol 30:3967\u20133975. doi:\n                    10.1200\/JCO.2011.40.8666","journal-title":"J Clin Oncol"},{"key":"3846_CR13","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1200\/JCO.2005.01.079","volume":"23","author":"CH Kroenke","year":"2005","unstructured":"Kroenke CH, Chen WY, Rosner B, Holmes MD (2005) Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol 23:1370\u20131378. doi:\n                    10.1200\/JCO.2005.01.079","journal-title":"J Clin Oncol"},{"key":"3846_CR14","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1158\/1055-9965.EPI-05-0042","volume":"14","author":"S Loi","year":"2005","unstructured":"Loi S, Milne RL, Friedlander ML, McCredie MR, Giles GG, Hopper JL, Phillips KA (2005) Obesity and outcomes in premenopausal and postmenopausal breast cancer. Cancer Epidemiol Biomark Prev 14:1686\u20131691. doi:\n                    10.1158\/1055-9965.EPI-05-0042","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"3846_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.clon.2010.02.001","volume":"22","author":"LA Healy","year":"2010","unstructured":"Healy LA, Ryan AM, Carroll P, Ennis D, Crowley V, Boyle T, Kennedy MJ, Connolly E, Reynolds JV (2010) Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer. Clin Oncol (R Coll Radiol) 22:281\u2013288. doi:\n                    10.1016\/j.clon.2010.02.001","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"3846_CR16","doi-asserted-by":"publisher","first-page":"189384","DOI":"10.1155\/2014\/189384","volume":"2014","author":"R Bhandari","year":"2014","unstructured":"Bhandari R, Kelley GA, Hartley TA, Rockett IR (2014) Metabolic syndrome is associated with increased breast cancer risk: a systematic review with meta-analysis. Int J Breast Cancer 2014:189384. doi:\n                    10.1155\/2014\/189384","journal-title":"Int J Breast Cancer"},{"key":"3846_CR17","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1097\/GME.0b013e31828ce95d","volume":"20","author":"K Esposito","year":"2013","unstructured":"Esposito K, Chiodini P, Capuano A, Bellastella G, Maiorino MI, Rafaniello C, Giugliano D (2013) Metabolic syndrome and postmenopausal breast cancer: systematic review and meta-analysis. Menopause 20:1301\u20131309. doi:\n                    10.1097\/GME.0b013e31828ce95d","journal-title":"Menopause"},{"key":"3846_CR18","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1093\/annonc\/mdr025","volume":"22","author":"V Rosato","year":"2011","unstructured":"Rosato V, Bosetti C, Talamini R, Levi F, Montella M, Giacosa A, Negri E, La Vecchia C (2011) Metabolic syndrome and the risk of breast cancer in postmenopausal women. Ann Oncol 22:2687\u20132692. doi:\n                    10.1093\/annonc\/mdr025","journal-title":"Ann Oncol"},{"key":"3846_CR19","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s10549-014-3157-6","volume":"148","author":"GS Calip","year":"2014","unstructured":"Calip GS, Malone KE, Gralow JR, Stergachis A, Hubbard RA, Boudreau DM (2014) Metabolic syndrome and outcomes following early-stage breast cancer. Breast Cancer Res Treat 148:363\u2013377. doi:\n                    10.1007\/s10549-014-3157-6","journal-title":"Breast Cancer Res Treat"},{"key":"3846_CR20","doi-asserted-by":"crossref","unstructured":"Chun J, Refinetti AP, Schnabel F, Price A, Billig J, Cimeno A, Schwartz S, Guth A, Axelrod D (2012)\u00a0Tumor characteristics in obese women with breast cancer. J Clin Oncol 30(suppl 27; abstr 179)","DOI":"10.1200\/jco.2012.30.27_suppl.179"},{"key":"3846_CR21","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/S0140-6736(05)66544-0","volume":"365","author":"Early Breast Cancer Trialists\u2019 Collaborative Group","year":"2005","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687\u20131717. doi:\n                    10.1016\/s0140-6736(05)66544-0","journal-title":"Lancet"},{"key":"3846_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1080\/07853890500300311","volume":"38","author":"DJ Magliano","year":"2006","unstructured":"Magliano DJ, Shaw JE, Zimmet PZ (2006) How to best define the metabolic syndrome. Ann Med 38:34\u201341. doi:\n                    10.1080\/07853890500300311","journal-title":"Ann Med"},{"key":"3846_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1242\/dmm.001180","volume":"2","author":"PL Huang","year":"2009","unstructured":"Huang PL (2009) A comprehensive definition for metabolic syndrome. Dis Model Mech 2:231\u2013237. doi:\n                    10.1242\/dmm.001180","journal-title":"Dis Model Mech"},{"key":"3846_CR24","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1200\/JCO.2009.22.7918","volume":"28","author":"MD Holmes","year":"2010","unstructured":"Holmes MD, Chen WY, Li L, Hertzmark E, Spiegelman D, Hankinson SE (2010) Aspirin intake and survival after breast cancer. J Clin Oncol 28:1467\u20131472. doi:\n                    10.1200\/JCO.2009.22.7918","journal-title":"J Clin Oncol"},{"key":"3846_CR25","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv006","author":"PJ Goodwin","year":"2015","unstructured":"Goodwin PJ, Parulekar WR, Gelmon KA, Shepherd LE, Ligibel JA, Hershman DL, Rastogi P, Mayer IA, Hobday TJ, Lemieux J, Thompson AM, Pritchard KI, Whelan TJ, Mukherjee SD, Chalchal HI, Oja CD, Tonkin KS, Bernstein V, Chen BE, Stambolic V (2015) Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32. J Natl Cancer. doi:\n                    10.1093\/jnci\/djv006","journal-title":"J Natl Cancer"},{"key":"3846_CR26","unstructured":"NCIC Clinical Trials Group. A phase III randomized trial of metformin vs placebo in early stage breast cancer. \n                    https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01101438\n                    \n                  . Accessed 25 May 2016"},{"key":"3846_CR27","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/jnci\/djj494","volume":"98","author":"RT Chlebowski","year":"2006","unstructured":"Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, Hudis C, Butler J, Merkel D, Kristal A, Caan B, Michaelson R, Vinciguerra V, Del Prete S, Winkler M, Hall R, Simon M, Winters BL, Elashoff RM (2006) Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women\u2019s Intervention Nutrition Study. J Natl Cancer Inst 98:1767\u20131776. doi:\n                    10.1093\/jnci\/djj494","journal-title":"J Natl Cancer Inst"},{"key":"3846_CR28","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/S0197-2456(02)00241-6","volume":"23","author":"JP Pierce","year":"2002","unstructured":"Pierce JP, Faerber S, Wright FA, Rock CL, Newman V, Flatt SW, Kealey S, Jones VE, Caan BJ, Gold EB, Haan M, Hollenbach KA, Jones L, Marshall JR, Ritenbaugh C, Stefanick ML, Thomson C, Wasserman L, Natarajan L, Thomas RG, Gilpin EA (2002) A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the Women\u2019s Healthy Eating and Living (WHEL) Study. Control Clin Trials 23:728\u2013756","journal-title":"Control Clin Trials"},{"key":"3846_CR29","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1200\/JCO.20.4.1128","volume":"20","author":"RT Chlebowski","year":"2002","unstructured":"Chlebowski RT, Aiello E, McTiernan A (2002) Weight loss in breast cancer patient management. J Clin Oncol 20:1128\u20131143","journal-title":"J Clin Oncol"},{"key":"3846_CR30","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1200\/JCO.2015.63.1440","volume":"33","author":"JA Ligibel","year":"2015","unstructured":"Ligibel JA, Alfano CM, Hershman D, Ballard RM, Bruinooge SS, Courneya KS, Daniels EC, Demark-Wahnefried W, Frank ES, Goodwin PJ, Irwin ML, Levit LA, McCaskill-Stevens W, Minasian LM, O\u2019Rourke MA, Pierce JP, Stein KD, Thomson CA, Hudis CA (2015) Recommendations for obesity clinical trials in cancer survivors: American Society of Clinical Oncology Statement. J Clin Oncol 33:3961\u20133967. doi:\n                    10.1200\/jco.2015.63.1440","journal-title":"J Clin Oncol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3846-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-016-3846-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3846-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-016-3846-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T12:49:00Z","timestamp":1589719740000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-016-3846-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["3846"],"URL":"https:\/\/doi.org\/10.1007\/s10549-016-3846-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"25 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No authors had any conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}