{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:12:03Z","timestamp":1790644323726,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T00:00:00Z","timestamp":1502496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Canadian Institutes of Health Research (CA)","award":["290987"],"award-info":[{"award-number":["290987"]}]},{"name":"Canadian Institutes of Health Research (CA)","award":["358914"],"award-info":[{"award-number":["358914"]}]},{"name":"Canadian Institutes of Health Research (CA)","award":["300068"],"award-info":[{"award-number":["300068"]}]},{"name":"Michael Smith Foundation for Health Research (CA)","award":["5553"],"award-info":[{"award-number":["5553"]}]},{"name":"Killam Trusts (CA)"},{"name":"Australian National Health and Medical Research Council","award":["1072266"],"award-info":[{"award-number":["1072266"]}]},{"name":"Faculty of Medicine Summer Student Research Program"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s10549-017-4449-4","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T04:50:29Z","timestamp":1502513429000},"page":"367-381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Does obesity modify the relationship between physical activity and breast cancer risk?"],"prefix":"10.1007","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-3403","authenticated-orcid":false,"given":"S. E.","family":"Neil-Sztramko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C.","family":"Gotay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,12]]},"reference":[{"issue":"1","key":"4449_CR1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3322\/caac.21203","volume":"64","author":"C DeSantis","year":"2014","unstructured":"DeSantis C, Ma J, Bryan L, Jemal A (2014) Breast cancer statistics, 2013. CA Cancer J Clin 64(1):52\u201362","journal-title":"CA Cancer J Clin"},{"key":"4449_CR2","unstructured":"Canadian Cancer Statistis (2014) Canadian Cancer Society\u2019s Advisory Committee on Cancer Statistics. Canadian Cancer Society, Toronto"},{"issue":"1","key":"4449_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1524-4741.2007.00515.x","volume":"14","author":"HT Lynch","year":"2008","unstructured":"Lynch HT, Silva E, Snyder C, Lynch JF (2008) Hereditary breast cancer: part I. Diagnosing hereditary breast cancer syndromes. Breast J 14(1):3\u201313","journal-title":"Breast J"},{"issue":"3","key":"4449_CR4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ijc.23303","volume":"122","author":"D Trichopoulos","year":"2008","unstructured":"Trichopoulos D, Adami HO, Ekbom A, Hsieh CC, Lagiou P (2008) Early life events and conditions and breast cancer risk: from epidemiology to etiology. Int J Cancer 122(3):481\u2013485","journal-title":"Int J Cancer"},{"key":"4449_CR5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/oxfordjournals.epirev.a036215","volume":"1","author":"JL Kelsey","year":"1979","unstructured":"Kelsey JL (1979) A review of the epidemiology of human breast cancer. Epidemiol Rev 1:74\u2013109","journal-title":"Epidemiol Rev"},{"key":"4449_CR6","volume-title":"Hormonal contraception and post-menopausal hormonal therapy","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"1999","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1999) Hormonal contraception and post-menopausal hormonal therapy, vol 72. IARC, Lyon"},{"key":"4449_CR7","volume-title":"Tobacco smoke and involuntary smoking","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2004","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004) Tobacco smoke and involuntary smoking, vol 83. IARC Press, Lyon"},{"key":"4449_CR8","first-page":"1","volume-title":"Combined estrogen-progestogen contraceptives and combined estrogen-progestogen menopausal therapy","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2007","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2007) Combined estrogen-progestogen contraceptives and combined estrogen-progestogen menopausal therapy, vol 91. International Agency for Research on Cancer, Lyon, pp 1\u2013528"},{"key":"4449_CR9","volume-title":"Alcohol consumption and ethyl carbamate","author":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2010","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2010) Alcohol consumption and ethyl carbamate, vol 96. International Agency for Research on Cancer, Lyon"},{"issue":"Suppl 2","key":"4449_CR10","first-page":"S94","volume":"11","author":"H Vainio","year":"2002","unstructured":"Vainio H, Kaaks R, Bianchini F (2002) Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 11(Suppl 2):S94\u2013S100","journal-title":"Eur J Cancer Prev"},{"key":"4449_CR11","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research (2009) Policy and action for cancer prevention. World Cancer Research Fund\/American Institute for Cancer Research, Washington, DC"},{"issue":"3","key":"4449_CR12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3322\/caac.21225","volume":"64","author":"GA Colditz","year":"2014","unstructured":"Colditz GA, Bohlke K (2014) Priorities for the primary prevention of breast cancer. CA Cancer J Clin 64(3):186\u2013194","journal-title":"CA Cancer J Clin"},{"key":"4449_CR13","volume-title":"Continuous update project report. Food, nutrition, physical activity, and the prevention of breast cancer","author":"World Cancer Research Fund\/American Institute for Cancer Research","year":"2010","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research (2010) Continuous update project report. Food, nutrition, physical activity, and the prevention of breast cancer. World Cancer Research Fund\/American Institute for Cancer Research, Washington, DC"},{"key":"4449_CR14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-642-04231-7_2","volume":"186","author":"BM Lynch","year":"2011","unstructured":"Lynch BM, Neilson HK, Friedenreich CM (2011) Physical activity and breast cancer prevention. Recent Results Cancer Res 186:13\u201342","journal-title":"Recent Results Cancer Res"},{"key":"4449_CR15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-1-60327-492-0_8","volume":"472","author":"SY Pan","year":"2009","unstructured":"Pan SY, DesMeules M (2009) Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence. Methods Mol Biol 472:191\u2013215","journal-title":"Methods Mol Biol"},{"issue":"6","key":"4449_CR16","doi-asserted-by":"crossref","first-page":"S530","DOI":"10.1097\/00005768-200106001-00025","volume":"33","author":"I Thune","year":"2001","unstructured":"Thune I, Furberg AS (2001) Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc 33(6):S530\u2013S550 (Discussion S510\u2013S609)","journal-title":"Med Sci Sports Exerc"},{"issue":"8","key":"4449_CR17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/bjsm.2006.029132","volume":"42","author":"CM Friedenreich","year":"2008","unstructured":"Friedenreich CM, Cust AE (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 42(8):636\u2013647","journal-title":"Br J Sports Med"},{"issue":"12","key":"4449_CR18","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1158\/1055-9965.EPI-08-0479","volume":"17","author":"ME Schmidt","year":"2008","unstructured":"Schmidt ME, Steindorf K, Mutschelknauss E, Slanger T, Kropp S, Obi N, Flesch-Janys D, Chang-Claude J (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomarkers Prev 17(12):3402\u20133410","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"4449_CR19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/jnci\/djp068","volume":"101","author":"R Ballard-Barbash","year":"2009","unstructured":"Ballard-Barbash R, Hunsberger S, Alciati MH, Blair SN, Goodwin PJ, McTiernan A, Wing R, Schatzkin A (2009) Physical activity, weight control, and breast cancer risk and survival: clinical trial rationale and design considerations. J Natl Cancer Inst 101(9):630\u2013643","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"4449_CR20","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/jama.2010.312","volume":"303","author":"IM Lee","year":"2010","unstructured":"Lee IM, Djousse L, Sesso HD, Wang L, Buring JE (2010) Physical activity and weight gain prevention. JAMA 303(12):1173\u20131179","journal-title":"JAMA"},{"issue":"10","key":"4449_CR21","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/j.1471-0528.2006.01021.x","volume":"113","author":"AR Carmichael","year":"2006","unstructured":"Carmichael AR (2006) Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 113(10):1160\u20131166","journal-title":"BJOG"},{"issue":"3","key":"4449_CR22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3945\/jn.115.221481","volume":"146","author":"M Deschasaux","year":"2016","unstructured":"Deschasaux M, Souberbielle JC, Latino-Martel P, Sutton A, Charnaux N, Druesne-Pecollo N, Galan P, Hercberg S, Le Clerc S, Kesse-Guyot E et al (2016) Weight status and alcohol intake modify the association between vitamin D and breast cancer risk. J Nutr 146(3):576\u2013585","journal-title":"J Nutr"},{"issue":"4","key":"4449_CR23","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3945\/ajcn.114.104323","volume":"102","author":"C Cadeau","year":"2015","unstructured":"Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC (2015) Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr 102(4):966\u2013973","journal-title":"Am J Clin Nutr"},{"key":"4449_CR24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejca.2015.10.063","volume":"52","author":"C Pizot","year":"2016","unstructured":"Pizot C, Boniol M, Mullie P, Koechlin A, Boniol M, Boyle P, Autier P (2016) Physical activity, hormone replacement therapy and breast cancer risk: a meta-analysis of prospective studies. Eur J Cancer 52:138\u2013154","journal-title":"Eur J Cancer"},{"issue":"6","key":"4449_CR25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/obr.12281","volume":"16","author":"S Schmidt","year":"2015","unstructured":"Schmidt S, Monk JM, Robinson LE, Mourtzakis M (2015) The integrative role of leptin, oestrogen and the insulin family in obesity-associated breast cancer: potential effects of exercise. Obes Rev 16(6):473\u2013487","journal-title":"Obes Rev"},{"key":"4449_CR26","unstructured":"Guyatt G, Busse J (2011) Tool to assess risk of bias in cohort studies. Hamilton"},{"key":"4449_CR27","unstructured":"Guyatt G, Busse J (2011) Tool to assess risk of bias in case-control studies. Hamilton"},{"key":"4449_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.epirev.a036298","volume":"9","author":"S Greenland","year":"1987","unstructured":"Greenland S (1987) Quantitative methods in the review of epidemiologic literature. Epidemiol Rev 9:1\u201330","journal-title":"Epidemiol Rev"},{"key":"4449_CR29","volume-title":"Meta-analysis in Stata: an updated collection from the Stata Journal","author":"JAC Sterne","year":"2009","unstructured":"Sterne JAC (2009) Meta-analysis in Stata: an updated collection from the Stata Journal. Stata Press, College Station"},{"issue":"2","key":"4449_CR30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1677\/erc.1.00729","volume":"13","author":"AM Lorincz","year":"2006","unstructured":"Lorincz AM, Sukumar S (2006) Molecular links between obesity and breast cancer. Endocr Relat Cancer 13(2):279\u2013292","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"4449_CR31","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13058-015-0647-3","volume":"17","author":"K Ennour-Idrissi","year":"2015","unstructured":"Ennour-Idrissi K, Maunsell E, Diorio C (2015) Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials. Breast Cancer Res 17(1):139","journal-title":"Breast Cancer Res"},{"issue":"19","key":"4449_CR32","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1200\/JCO.2011.37.9792","volume":"30","author":"KL Campbell","year":"2012","unstructured":"Campbell KL, Foster-Schubert KE, Alfano CM, Wang CC, Wang CY, Duggan CR, Mason C, Imayama I, Kong A, Xiao L et al (2012) Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial. J Clin Oncol 30(19):2314\u20132326","journal-title":"J Clin Oncol"},{"issue":"3","key":"4449_CR33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ijo.2009.251","volume":"34","author":"KH Pietilainen","year":"2010","unstructured":"Pietilainen KH, Korkeila M, Bogl LH, Westerterp KR, Yki-Jarvinen H, Kaprio J, Rissanen A (2010) Inaccuracies in food and physical activity diaries of obese subjects: complementary evidence from doubly labeled water and co-twin assessments. Int J Obes 34(3):437\u2013445","journal-title":"Int J Obes"},{"issue":"2","key":"4449_CR34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5993\/AJHB.36.2.3","volume":"36","author":"ET Warner","year":"2012","unstructured":"Warner ET, Wolin KY, Duncan DT, Heil DP, Askew S, Bennett GG (2012) Differential accuracy of physical activity self-report by body mass index. Am J Health Behav 36(2):168\u2013178","journal-title":"Am J Health Behav"},{"issue":"1","key":"4449_CR35","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1007\/BF03405657","volume":"104","author":"CC Gotay","year":"2012","unstructured":"Gotay CC, Katzmarzyk PT, Janssen I, Dawson MY, Aminoltejari K, Bartley NL (2012) Updating the Canadian obesity maps: an epidemic in progress. Can J Public Health 104(1):e64\u2013e68","journal-title":"Can J Public Health"},{"key":"4449_CR36","volume-title":"Epidemiology: an introduction","author":"KJ Rothman","year":"2012","unstructured":"Rothman KJ (2012) Epidemiology: an introduction, 2nd edn edn. Oxford University Press, New York","edition":"2"},{"issue":"1","key":"4449_CR37","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/EDE.0b013e318193e7b5","volume":"20","author":"S Greenland","year":"2009","unstructured":"Greenland S (2009) Interactions in epidemiology: relevance, identification, and estimation. Epidemiology 20(1):14\u201317","journal-title":"Epidemiology"},{"issue":"2","key":"4449_CR38","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/EDE.0b013e31818f6651","volume":"20","author":"MJ Knol","year":"2009","unstructured":"Knol MJ, Egger M, Scott P, Geerlings MI, Vandenbroucke JP (2009) When one depends on the other: reporting of interaction in case-control and cohort studies. Epidemiology 20(2):161\u2013166","journal-title":"Epidemiology"},{"issue":"10","key":"4449_CR39","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0040297","volume":"4","author":"JP Vandenbroucke","year":"2007","unstructured":"Vandenbroucke JP, von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M, Initiative S (2007) Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Med 4(10):e297","journal-title":"PLoS Med"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-017-4449-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-017-4449-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-017-4449-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T06:32:50Z","timestamp":1569997970000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-017-4449-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,12]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["4449"],"URL":"https:\/\/doi.org\/10.1007\/s10549-017-4449-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,12]]}}}