{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:19:53Z","timestamp":1787235593311,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s10549-017-4657-y","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T01:17:15Z","timestamp":1515979035000},"page":"739-744","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Breast conserving surgery in combination with intraoperative radiotherapy after previous external beam therapy: an option to avoid mastectomy"],"prefix":"10.1007","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-7303","authenticated-orcid":false,"given":"F.","family":"Thangarajah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Malter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Marnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mallmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"4657_CR1","unstructured":"AGO Breast Committee (2017) Diagnosis and treatment of patients with primary and metastatic breast cancer. Recommendations. \n                    www.ago-online.de"},{"issue":"11","key":"4657_CR2","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1002\/cncr.20257","volume":"100","author":"HM Kuerer","year":"2004","unstructured":"Kuerer HM, Arthur DW, Haffty BG (2004) Repeat breast-conserving surgery for in-breast local breast carcinoma recurrence: the potential role of partial breast irradiation. Cancer 100(11):2269\u20132280. \n                    https:\/\/doi.org\/10.1002\/cncr.20257","journal-title":"Cancer"},{"key":"4657_CR3","doi-asserted-by":"publisher","first-page":"571946","DOI":"10.1155\/2012\/571946","volume":"2012","author":"J Siglin","year":"2012","unstructured":"Siglin J, Champ CE, Vakhnenko Y et al (2012) Radiation therapy for locally recurrent breast cancer. Int J breast cancer 2012:571946. \n                    https:\/\/doi.org\/10.1155\/2012\/571946","journal-title":"Int J breast cancer"},{"issue":"1","key":"4657_CR4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1046\/j.1365-2168.1999.00961.x","volume":"86","author":"B Salvadori","year":"1999","unstructured":"Salvadori B, Marubini E, Miceli R et al (1999) Reoperation for locally recurrent breast cancer in patients previously treated with conservative surgery. Br J Surg 86(1):84\u201387. \n                    https:\/\/doi.org\/10.1046\/j.1365-2168.1999.00961.x","journal-title":"Br J Surg"},{"issue":"1","key":"4657_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1023\/A:1005934513072","volume":"49","author":"K Dalberg","year":"1998","unstructured":"Dalberg K, Mattsson A, Sandelin K et al (1998) Outcome of treatment for ipsilateral breast tumor recurrence in early-stage breast cancer. Breast Cancer Res Treat 49(1):69\u201378","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"4657_CR6","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/1097-0142(19930301)71:5<1774::AID-CNCR2820710511>3.0.CO;2-V","volume":"71","author":"CC Cajucom","year":"1993","unstructured":"Cajucom CC, Tsangaris TN, Nemoto T et al (1993) Results of salvage mastectomy for local recurrence after breast-conserving surgery without radiation therapy. Cancer 71(5):1774\u20131779","journal-title":"Cancer"},{"issue":"1","key":"4657_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0360-3016(89)90003-5","volume":"16","author":"A Recht","year":"1989","unstructured":"Recht A, Schnitt SJ, Connolly JL et al (1989) Prognosis following local or regional recurrence after conservative surgery and radiotherapy for early stage breast carcinoma. Int J Radiat Oncol Biol Phys 16(1):3\u20139","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"4657_CR8","first-page":"189","volume":"174","author":"MP Osborne","year":"1992","unstructured":"Osborne MP, Borgen PI, Wong GY et al (1992) Salvage mastectomy for local and regional recurrence after breast-conserving operation and radiation therapy. Surg, Gynecol obstet 174(3):189\u2013194","journal-title":"Surg, Gynecol obstet"},{"issue":"8","key":"4657_CR9","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1002\/1097-0142(19890415)63:8<1630::AID-CNCR2820630833>3.0.CO;2-U","volume":"63","author":"JM Kurtz","year":"1989","unstructured":"Kurtz JM, Jacquemier J, Torhorst J et al (1989) Conservation therapy for breast cancers other than infiltrating ductal carcinoma. Cancer 63(8):1630\u20131635","journal-title":"Cancer"},{"issue":"33","key":"4657_CR10","doi-asserted-by":"publisher","first-page":"35051","DOI":"10.18632\/oncotarget.6036","volume":"6","author":"T Merino","year":"2015","unstructured":"Merino T, Tran WT, Czarnota GJ (2015) Re-irradiation for locally recurrent refractory breast cancer. Oncotarget 6(33):35051\u201335062. \n                    https:\/\/doi.org\/10.18632\/oncotarget.6036","journal-title":"Oncotarget"},{"issue":"2","key":"4657_CR11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.semradonc.2004.10.007","volume":"15","author":"JS Vaidya","year":"2005","unstructured":"Vaidya JS, Tobias JS, Baum M et al (2005) TARGeted Intraoperative radiotherapy (TARGIT): an innovative approach to partial-breast irradiation. Semin Radiat Oncol 15(2):84\u201391","journal-title":"Semin Radiat Oncol"},{"key":"4657_CR12","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/1471-2407-7-178","volume":"7","author":"U Kraus-Tiefenbacher","year":"2007","unstructured":"Kraus-Tiefenbacher U, Bauer L, Scheda A et al (2007) Intraoperative radiotherapy (IORT) is an option for patients with localized breast recurrences after previous external-beam radiotherapy. BMC cancer 7:178. \n                    https:\/\/doi.org\/10.1186\/1471-2407-7-178","journal-title":"BMC cancer"},{"issue":"1","key":"4657_CR13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s13014-016-0749-9","volume":"12","author":"F Sedlmayer","year":"2017","unstructured":"Sedlmayer F, Reitsamer R, Wenz F et al (2017) Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiat Oncol (Lond, Engl) 12(1):23. \n                    https:\/\/doi.org\/10.1186\/s13014-016-0749-9","journal-title":"Radiat Oncol (Lond, Engl)"},{"issue":"9735","key":"4657_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0140-6736(10)60837-9","volume":"376","author":"JS Vaidya","year":"2010","unstructured":"Vaidya JS, Joseph DJ, Tobias JS et al (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial). An international, prospective, randomised, non-inferiority phase 3 trial. Lancet (Lond, Engl) 376(9735):91\u2013102. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(10)60837-9","journal-title":"Lancet (Lond, Engl)"},{"issue":"4","key":"4657_CR15","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0360-3016(02)04202-5","volume":"55","author":"U Hoeller","year":"2003","unstructured":"Hoeller U, Tribius S, Kuhlmey A et al (2003) Increasing the rate of late toxicity by changing the score? A comparison of RTOG\/EORTC and LENT\/SOMA scores. Int J Radiat Oncol Biol Phys 55(4):1013\u20131018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"4657_CR16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.5152\/tjbh.2014.1919","volume":"10","author":"M Ak\u00e7a","year":"2013","unstructured":"Ak\u00e7a M, Ata A, Nay\u0131r E et al (2013) Impact of surgery type on quality of life in breast cancer patients. J Breast health 10(4):222\u2013228. \n                    https:\/\/doi.org\/10.5152\/tjbh.2014.1919","journal-title":"J Breast health"},{"issue":"1","key":"4657_CR17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s10549-012-2349-1","volume":"137","author":"S-Y Fang","year":"2013","unstructured":"Fang S-Y, Shu B-C, Chang Y-J (2013) The effect of breast reconstruction surgery on body image among women after mastectomy. A meta-analysis. Breast Cancer Res Treat 137(1):13\u201321. \n                    https:\/\/doi.org\/10.1007\/s10549-012-2349-1","journal-title":"Breast Cancer Res Treat"},{"issue":"Suppl 1","key":"4657_CR18","doi-asserted-by":"publisher","first-page":"C29","DOI":"10.4103\/0973-1482.163835","volume":"11","author":"Z Chen","year":"2015","unstructured":"Chen Z, Xu Y, Shu J et al (2015) Breast-conserving surgery versus modified radical mastectomy in treatment of early stage breast cancer: a retrospective study of 107 cases. J Cancer Res Ther 11(Suppl 1):C29\u2013C31. \n                    https:\/\/doi.org\/10.4103\/0973-1482.163835","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"4657_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.radonc.2011.07.020","volume":"102","author":"D Kauer-Dorner","year":"2012","unstructured":"Kauer-Dorner D, P\u00f6tter R, Resch A et al (2012) Partial breast irradiation for locally recurrent breast cancer within a second breast conserving treatment: alternative to mastectomy? Results from a prospective trial. Radiother Oncol 102(1):96\u2013101. \n                    https:\/\/doi.org\/10.1016\/j.radonc.2011.07.020","journal-title":"Radiother Oncol"},{"issue":"Suppl 3","key":"4657_CR20","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1016\/S0960-9776(11)70304-6","volume":"20","author":"M Intra","year":"2011","unstructured":"Intra M, Mattar D, Sangalli C et al (2011) Local therapy for breast cancer in malignant lymphoma survivors. Breast (Edinb, Scotl) 20(Suppl 3):S99\u2013103. \n                    https:\/\/doi.org\/10.1016\/S0960-9776(11)70304-6","journal-title":"Breast (Edinb, Scotl)"},{"issue":"4","key":"4657_CR21","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.rpor.2017.02.009","volume":"22","author":"G Blandino","year":"2017","unstructured":"Blandino G, Guenzi M, Belgioia L et al (2017) Adjuvant intraoperative radiotherapy for selected breast cancers in previously irradiated women. Evidence for excellent feasibility and favorable outcomes. Rep Practical Oncol Radiother 22(4):277\u2013283. \n                    https:\/\/doi.org\/10.1016\/j.rpor.2017.02.009","journal-title":"Rep Practical Oncol Radiother"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-017-4657-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-017-4657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-017-4657-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T20:37:07Z","timestamp":1547498227000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-017-4657-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,15]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["4657"],"URL":"https:\/\/doi.org\/10.1007\/s10549-017-4657-y","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,15]]},"assertion":[{"value":"23 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"FT, JH, RS, SK, SM, PM and ES do not have any conflict of interest to declare. WM works as a consultant for Carl Zeiss AG. FW receives research funding from Carl Zeiss AG and works as a consultant for this company.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}