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MPL received honoraria from Pfizer, Roche, MSD, Hexal, Novartis, AstraZeneca, Celgene, Eisai, Medac, and Thieme for advisory boards, lectures, and travel support. WJ received research grants from Novartis. ADH participated on advisory boards for Novartis. RW participated on advisory boards for Novartis, AstraZeneca, Pfizer, and Lilly. SK participated on advisory boards for Roche\/Genentech, Genomic Health, Novartis, AstraZeneca, Amgen, Celgene, SOMATEX, Daiichi Sankyo, Puma Biotechnology, pfm medical, Pfizer, and MSD Oncology and received funding from Roche and Daiichi Sankyo. CT received honoraria from Amgen, AstraZeneca, Celgene, Genomic Health, Lilly, NanoString, Novartis, Pfizer, Puma, and Roche for lectures and advisory boards. CCH received honoraria from Roche. PG received honoraria from Novartis, Roche, and PharmaMar. NN received honoraria from Janssen-Cilag and Novartis. HCK received honoraria from Carl Zeiss Meditec, TEVA, Theraclion, Novartis, Amgen, AstraZeneca, Pfizer, Janssen-Cilag, GSK, LIV Pharma, Roche, and Genomic Health and is stock owner of Theraclion and Phaon Scientific GmbH. MW participated on advisory boards for Novartis, Roche, Pfizer, and Celgene. BR participated on advisory boards for Novartis and Roche and received funding from AstraZeneca, Chugai, Lilly, Novartis, Janssen-Cilag, and Sanofi Aventis. TF participated on advisory boards for Novartis, Roche, AstraZeneca, Pfizer, and Daiichi Sankyo. MWB\u2019s institution received research grants from Novartis. PAF received honoraria from Novartis, Roche, Pfizer, and Amgen. CR received honoraria from Novartis, Roche, Celgene, and Eisai. All remaining authors have declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval for the study was obtained from the ethics committee of the Faculty of Medicine at Friedrich Alexander University of Erlangen-Nuremberg and all of the relevant local ethics committees. All procedures were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the patients as part of the inclusion criteria before they entered the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}