{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:38:54Z","timestamp":1775666334251,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T00:00:00Z","timestamp":1526515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000015","name":"Canadian Cancer Society Research Institute","doi-asserted-by":"publisher","award":["703058"],"award-info":[{"award-number":["703058"]}],"id":[{"id":"10.13039\/501100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10549-018-4822-y","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T08:24:02Z","timestamp":1526545442000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers"],"prefix":"10.1007","volume":"171","author":[{"name":"the Hereditary Breast Cancer Clinical Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Kotsopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Gronwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Neuhausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ainsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey N.","family":"Weitzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuya","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian F.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigha","family":"Senter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lubinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-0626","authenticated-orcid":false,"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"4822_CR1","doi-asserted-by":"publisher","first-page":"143153","DOI":"10.1016\/j.molmed.2013.11.002","volume":"20","author":"F Meier-Abt","year":"2014","unstructured":"Meier-Abt F, Bentires-Alj M (2014) How pregnancy at early age protects against breast cancer. Trends Mol Med 20:143\u2013153","journal-title":"Trends Mol Med"},{"key":"4822_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-014-2852-7","volume":"144","author":"KN Anderson","year":"2014","unstructured":"Anderson KN, Schwab RB, Martinez ME (2014) Reproductive risk factors and breast cancer subtypes: a review of the literature. Breast Cancer Res Treat 144:1\u201310","journal-title":"Breast Cancer Res Treat"},{"key":"4822_CR3","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1158\/0008-5472.CAN-14-2717","volume":"75","author":"F Meier-Abt","year":"2015","unstructured":"Meier-Abt F, Bentires-Alj M, Rochlitz C (2015) Breast cancer prevention: lessons to be learned from mechanisms of early pregnancy-mediated breast cancer protection. Cancer Res 75:803\u2013807","journal-title":"Cancer Res"},{"key":"4822_CR4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fendo.2014.00213","volume":"5","author":"M Barton","year":"2014","unstructured":"Barton M, Santucci-Pereira J, Russo J (2014) Molecular pathways involved in pregnancy-induced prevention against breast cancer. Front Endocrinol (Lausanne) 5:213","journal-title":"Front Endocrinol (Lausanne)"},{"key":"4822_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ctrv.2016.07.006","volume":"49","author":"M Lambertini","year":"2016","unstructured":"Lambertini M, Santoro L, Del Mastro L et al (2016) Reproductive behaviors and risk of developing breast cancer according to tumor subtype: a systematic review and meta-analysis of epidemiological studies. Cancer Treat Rev 49:65\u201376","journal-title":"Cancer Treat Rev"},{"key":"4822_CR6","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s10549-017-4557-1","volume":"167","author":"DG Evans","year":"2018","unstructured":"Evans DG, Harkness EF, Howel S et al (2018) Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 167:779\u2013785","journal-title":"Breast Cancer Res Treat"},{"key":"4822_CR7","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10549-006-9441-3","volume":"105","author":"J Kotsopoulos","year":"2007","unstructured":"Kotsopoulos J, Lubinski J, Lynch HT et al (2007) Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 105:221\u2013228","journal-title":"Breast Cancer Res Treat"},{"key":"4822_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canep.2013.11.004","volume":"38","author":"H Pan","year":"2014","unstructured":"Pan H, He Z, Ling L et al (2014) Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation carriers: results from ten studies. Cancer Epidemiol 38:1\u20138","journal-title":"Cancer Epidemiol"},{"key":"4822_CR9","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/bcr3138","volume":"14","author":"J Kotsopoulos","year":"2012","unstructured":"Kotsopoulos J, Lubinski J, Salmena L et al (2012) Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 14:R42","journal-title":"Breast Cancer Res"},{"key":"4822_CR10","doi-asserted-by":"publisher","first-page":"988991","DOI":"10.1002\/ijc.21273","volume":"117","author":"CA Cullinane","year":"2005","unstructured":"Cullinane CA, Lubinski J, Neuhausen SL et al (2005) Effect of pregnancy as a risk factor for breast cancer in BRCA1\/BRCA2 mutation carriers. Int J Cancer 117:988\u2013991","journal-title":"Int J Cancer"},{"key":"4822_CR11","doi-asserted-by":"publisher","first-page":"9144","DOI":"10.18632\/oncotarget.13423","volume":"8","author":"A Toss","year":"2017","unstructured":"Toss A, Grandi G, Cagnacci A et al (2017) The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation. Oncotarget 8:9144\u20139154","journal-title":"Oncotarget"},{"key":"4822_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/mgg3.191","volume":"4","author":"V Rieder","year":"2016","unstructured":"Rieder V, Salama M, Glockner L et al (2016) Effect of lifestyle and reproductive factors on the onset of breast cancer in female BRCA 1 and 2 mutation carriers. Mol Genet Genomic Med 4:172\u2013177","journal-title":"Mol Genet Genomic Med"},{"key":"4822_CR13","doi-asserted-by":"crossref","first-page":"102110","DOI":"10.18632\/oncotarget.22193","volume":"8","author":"B Park","year":"2017","unstructured":"Park B, Hopper JL, Win AK et al (2017) Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers. Oncotarget 8:102110\u2013102118","journal-title":"Oncotarget"},{"key":"4822_CR14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/hmbci-2011-0136","volume":"9","author":"J Russo","year":"2012","unstructured":"Russo J, Russo IH (2012) Molecular basis of pregnancy-induced breast cancer prevention. Horm Mol Biol Clin Investig 9:3\u201310","journal-title":"Horm Mol Biol Clin Investig"},{"key":"4822_CR15","doi-asserted-by":"publisher","first-page":"221233","DOI":"10.1007\/s10911-011-9228-y","volume":"16","author":"IH Russo","year":"2011","unstructured":"Russo IH, Russo J (2011) Pregnancy-induced changes in breast cancer risk. J Mammary Gland Biol Neoplasia 16:221\u2013233","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"4822_CR16","doi-asserted-by":"publisher","first-page":"907913","DOI":"10.1038\/nm.2000","volume":"15","author":"E Lim","year":"2009","unstructured":"Lim E, Vaillant F, Wu D et al (2009) Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15:907\u2013913","journal-title":"Nat Med"},{"key":"4822_CR17","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/nm.4118","volume":"22","author":"E Nolan","year":"2016","unstructured":"Nolan E, Vaillant F, Branstetter D et al (2016) RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers. Nat Med 22:933","journal-title":"Nat Med"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-018-4822-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4822-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4822-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T20:52:03Z","timestamp":1661287923000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-018-4822-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,17]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4822"],"URL":"https:\/\/doi.org\/10.1007\/s10549-018-4822-y","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,17]]},"assertion":[{"value":"1 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}