{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:37:10Z","timestamp":1784025430596,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000869","name":"Susan G. Komen for the Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s10549-018-4916-6","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T06:00:41Z","timestamp":1535004041000},"page":"487-496","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Histopathologic characteristics of background parenchymal enhancement (BPE) on breast MRI"],"prefix":"10.1007","volume":"172","author":[{"given":"Janice S.","family":"Sung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana D.","family":"Corben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Edelweiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia M.","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prusha","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Robson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonine L.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm C.","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"issue":"6","key":"4916_CR1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1055-9965.epi-06-0034","volume":"15","author":"VA McCormack","year":"2006","unstructured":"McCormack VA, dos Santos Silva I (2006) Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomark Prev 15(6):1159\u20131169. https:\/\/doi.org\/10.1158\/1055-9965.epi-06-0034","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"1","key":"4916_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mric.2009.09.005","volume":"18","author":"EA Morris","year":"2010","unstructured":"Morris EA (2010) Diagnostic breast MR imaging: current status and future directions. Magn Reson Imaging Clin N Am 18(1):57\u201374. https:\/\/doi.org\/10.1016\/j.mric.2009.09.005","journal-title":"Magn Reson Imaging Clin N Am"},{"issue":"1","key":"4916_CR3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1148\/radiol.11102156","volume":"260","author":"V King","year":"2011","unstructured":"King V, Brooks JD, Bernstein JL, Reiner AS, Pike MC, Morris EA (2011) Background parenchymal enhancement at breast MR imaging and breast cancer risk. Radiology 260(1):50\u201360. https:\/\/doi.org\/10.1148\/radiol.11102156","journal-title":"Radiology"},{"issue":"2","key":"4916_CR4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1148\/radiol.2015142304","volume":"276","author":"BN Dontchos","year":"2015","unstructured":"Dontchos BN, Rahbar H, Partridge SC, Korde LA, Lam DL, Scheel JR, Peacock S, Lehman CD (2015) Are qualitative assessments of background parenchymal enhancement, amount of fibroglandular tissue on MR images, and mammographic density associated with breast cancer risk? Radiology 276(2):371\u2013380. https:\/\/doi.org\/10.1148\/radiol.2015142304","journal-title":"Radiology"},{"issue":"2","key":"4916_CR5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.mri.2015.10.014","volume":"34","author":"M Telegrafo","year":"2016","unstructured":"Telegrafo M, Rella L, Stabile Ianora AA, Angelelli G, Moschetta M (2016) Breast MRI background parenchymal enhancement (BPE) correlates with the risk of breast cancer. Magn Reson Imaging 34(2):173\u2013176. https:\/\/doi.org\/10.1016\/j.mri.2015.10.014","journal-title":"Magn Reson Imaging"},{"issue":"1","key":"4916_CR6","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s13058-016-0734-0","volume":"18","author":"S Wu","year":"2016","unstructured":"Wu S, Berg WA, Zuley ML, Kurland BF, Jankowitz RC, Nishikawa R, Gur D, Sumkin JH (2016) Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer. Breast Cancer Res 18(1):76. https:\/\/doi.org\/10.1186\/s13058-016-0734-0","journal-title":"Breast Cancer Res"},{"key":"4916_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2018.03.013","author":"LJ Grimm","year":"2018","unstructured":"Grimm LJ, Saha A, Ghate SV, Kim C, Soo MS, Yoon SC, Mazurowski MA (2018) Relationship between background parenchymal enhancement on high-risk screening MRI and future breast cancer risk. Acad Radiol. https:\/\/doi.org\/10.1016\/j.acra.2018.03.013","journal-title":"Acad Radiol"},{"issue":"7","key":"4916_CR8","doi-asserted-by":"publisher","first-page":"e0158573","DOI":"10.1371\/journal.pone.0158573","volume":"11","author":"B Bennani-Baiti","year":"2016","unstructured":"Bennani-Baiti B, Dietzel M, Baltzer PA (2016) MRI background parenchymal enhancement is not associated with breast cancer. PLoS ONE 11(7):e0158573. https:\/\/doi.org\/10.1371\/journal.pone.0158573","journal-title":"PLoS ONE"},{"issue":"2","key":"4916_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/jmri.24495","volume":"40","author":"NL Hansen","year":"2014","unstructured":"Hansen NL, Kuhl CK, Barabasch A, Strobel K, Schrading S (2014) Does MRI breast \u201cdensity\u201d (degree of background enhancement) correlate with mammographic breast density? J Magn Reson Imaging 40(2):483\u2013489. https:\/\/doi.org\/10.1002\/jmri.24495","journal-title":"J Magn Reson Imaging"},{"issue":"12","key":"4916_CR10","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1007\/s00330-012-2553-8","volume":"22","author":"V King","year":"2012","unstructured":"King V, Gu Y, Kaplan JB, Brooks JD, Pike MC, Morris EA (2012) Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI. Eur Radiol 22(12):2641\u20132647. https:\/\/doi.org\/10.1007\/s00330-012-2553-8","journal-title":"Eur Radiol"},{"issue":"3","key":"4916_CR11","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1148\/radiol.13120121","volume":"267","author":"AM Scaranelo","year":"2013","unstructured":"Scaranelo AM, Carrillo MC, Fleming R, Jacks LM, Kulkarni SR, Crystal P (2013) Pilot study of quantitative analysis of background enhancement on breast MR images: association with menstrual cycle and mammographic breast density. Radiology 267(3):692\u2013700. https:\/\/doi.org\/10.1148\/radiol.13120121","journal-title":"Radiology"},{"issue":"6","key":"4916_CR12","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/tbj.12002","volume":"18","author":"V King","year":"2012","unstructured":"King V, Kaplan J, Pike MC, Liberman L, David Dershaw D, Lee CH, Brooks JD, Morris EA (2012) Impact of tamoxifen on amount of fibroglandular tissue, background parenchymal enhancement, and cysts on breast magnetic resonance imaging. Breast J 18(6):527\u2013534. https:\/\/doi.org\/10.1111\/tbj.12002","journal-title":"Breast J"},{"issue":"3","key":"4916_CR13","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1148\/radiol.12112669","volume":"264","author":"V King","year":"2012","unstructured":"King V, Goldfarb SB, Brooks JD, Sung JS, Nulsen BF, Jozefara JE, Pike MC, Dickler MN, Morris EA (2012) Effect of aromatase inhibitors on background parenchymal enhancement and amount of fibroglandular tissue at breast MR imaging. Radiology 264(3):670\u2013678. https:\/\/doi.org\/10.1148\/radiol.12112669","journal-title":"Radiology"},{"issue":"4","key":"4916_CR14","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/gme.0b013e31823772a8","volume":"19","author":"NA Mousa","year":"2012","unstructured":"Mousa NA, Eiada R, Crystal P, Nayot D, Casper RF (2012) The effect of acute aromatase inhibition on breast parenchymal enhancement in magnetic resonance imaging: a prospective pilot clinical trial. Menopause 19(4):420\u2013425. https:\/\/doi.org\/10.1097\/gme.0b013e31823772a8","journal-title":"Menopause"},{"issue":"3","key":"4916_CR15","doi-asserted-by":"publisher","first-page":"R232","DOI":"10.1186\/bcr779","volume":"6","author":"S Pfleiderer","year":"2004","unstructured":"Pfleiderer S, Sachse S, Sauner D, Marx C, Malich A, Wurdinger S, Kaiser W (2004) Changes in magnetic resonance mammography due to hormone replacement therapy. Breast Cancer Res 6(3):R232 R238","journal-title":"Breast Cancer Res"},{"issue":"1","key":"4916_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1148\/radiol.2351040012","volume":"235","author":"J-P Delille","year":"2005","unstructured":"Delille J-P, Slanetz PJ, Yeh ED, Kopans DB, Halpern EF, Garrido L (2005) Hormone replacement therapy in postmenopausal women: breast tissue perfusion determined with MR imaging\u2014initial observations. Radiology 235(1):36\u201341. https:\/\/doi.org\/10.1148\/radiol.2351040012","journal-title":"Radiology"},{"issue":"3","key":"4916_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1097\/00004728-199905000-00015","volume":"23","author":"JR Reichenbach","year":"1999","unstructured":"Reichenbach JR, Przetak C, Klinger G, Kaiser WA (1999) Assessment of breast tissue changes on hormonal replacement therapy using MRI: a pilot study. J Comput Assist Tomogr 23(3):407\u2013413","journal-title":"J Comput Assist Tomogr"},{"issue":"12","key":"4916_CR18","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/aje\/kwn090","volume":"167","author":"RL Prentice","year":"2008","unstructured":"Prentice RL, Chlebowski RT, Stefanick ML, Manson JE, Langer RD, Pettinger M, Hendrix SL, Hubbell FA, Kooperberg C, Kuller LH, Lane DS, McTiernan A, O\u2019Sullivan MJ, Rossouw JE, Anderson GL (2008) Conjugated equine estrogens and breast cancer risk in the Women\u2019s Health Initiative clinical trial and observational study. Am J Epidemiol 167(12):1407\u20131415. https:\/\/doi.org\/10.1093\/aje\/kwn090","journal-title":"Am J Epidemiol"},{"issue":"3","key":"4916_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.acra.2015.11.011","volume":"23","author":"AA Lewin","year":"2016","unstructured":"Lewin AA, Kim SG, Babb JS, Melsaether AN, McKellop J, Moccaldi M, Klautau Leite AP, Moy L (2016) Assessment of background parenchymal enhancement and lesion kinetics in breast MRI of BRCA 1\/2 mutation carriers compared to matched controls using quantitative kinetic analysis. Acad Radiol 23(3):358\u2013367. https:\/\/doi.org\/10.1016\/j.acra.2015.11.011","journal-title":"Acad Radiol"},{"issue":"4","key":"4916_CR20","doi-asserted-by":"publisher","first-page":"W373","DOI":"10.2214\/AJR.10.6272","volume":"198","author":"WB DeMartini","year":"2012","unstructured":"DeMartini WB, Liu F, Peacock S, Eby PR, Gutierrez RL, Lehman CD (2012) Background parenchymal enhancement on breast MRI: impact on diagnostic performance. AJR Am J Roentgenol 198(4):W373\u2013W380. https:\/\/doi.org\/10.2214\/AJR.10.6272","journal-title":"AJR Am J Roentgenol"},{"issue":"22","key":"4916_CR21","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.1158\/1078-0432.CCR-12-2603","volume":"19","author":"LR Howe","year":"2013","unstructured":"Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ (2013) Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res 19(22):6074\u20136083. https:\/\/doi.org\/10.1158\/1078-0432.CCR-12-2603","journal-title":"Clin Cancer Res"},{"issue":"3","key":"4916_CR22","doi-asserted-by":"publisher","first-page":"T51","DOI":"10.1530\/JME-13-0217","volume":"51","author":"ER Simpson","year":"2013","unstructured":"Simpson ER, Brown KA (2013) Obesity and breast cancer: role of inflammation and aromatase. J Mol Endocrinol 51(3):T51\u2013T59. https:\/\/doi.org\/10.1530\/JME-13-0217","journal-title":"J Mol Endocrinol"},{"issue":"12","key":"4916_CR23","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1182\/blood.V75.12.2417.2417","volume":"75","author":"L Fina","year":"1990","unstructured":"Fina L, Molgaard HV, Robertson D, Bradley NJ, Monaghan P, Delia D, Sutherland DR, Baker MA, Greaves MF (1990) Expression of the CD34 gene in vascular endothelial cells. Blood 75(12):2417\u20132426","journal-title":"Blood"},{"issue":"1","key":"4916_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jb\/mvu031","volume":"156","author":"K Matsumoto","year":"2014","unstructured":"Matsumoto K, Ema M (2014) Roles of VEGF-A signalling in development, regeneration, and tumours. J Biochem 156(1):1\u201310. https:\/\/doi.org\/10.1093\/jb\/mvu031","journal-title":"J Biochem"},{"key":"4916_CR25","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/215158","author":"C Sobolewski","year":"2010","unstructured":"Sobolewski C, Cerella C, Dicato M, Ghibelli L, Diederich M (2010) The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol. https:\/\/doi.org\/10.1155\/2010\/215158","journal-title":"Int J Cell Biol"},{"key":"4916_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","volume":"32","author":"MA Travis","year":"2014","unstructured":"Travis MA, Sheppard D (2014) TGF-beta activation and function in immunity. Annu Rev Immunol 32:51\u201382. https:\/\/doi.org\/10.1146\/annurev-immunol-032713-120257","journal-title":"Annu Rev Immunol"},{"issue":"7","key":"4916_CR27","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1158\/1940-6207.CAPR-11-0110","volume":"4","author":"PG Morris","year":"2011","unstructured":"Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ (2011) Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res 4(7):1021\u20131029. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-11-0110","journal-title":"Cancer Prev Res"},{"issue":"3","key":"4916_CR28","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.3892\/or.2013.2943","volume":"31","author":"R Camerlingo","year":"2014","unstructured":"Camerlingo R, Ferraro GA, De Francesco F, Romano M, Nicoletti G, Di Bonito M, Rinaldo M, D\u2019Andrea F, Pirozzi G (2014) The role of CD44+\/CD24-\/low biomarker for screening, diagnosis and monitoring of breast cancer. Oncol Rep 31(3):1127\u20131132. https:\/\/doi.org\/10.3892\/or.2013.2943","journal-title":"Oncol Rep"},{"issue":"4","key":"4916_CR29","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1075-122X.2005.21499.x","volume":"11","author":"JP Delille","year":"2005","unstructured":"Delille JP, Slanetz PJ, Yeh ED, Kopans DB, Garrido L (2005) Physiologic changes in breast magnetic resonance imaging during the menstrual cycle: perfusion imaging, signal enhancement, and influence of the T1 relaxation time of breast tissue. Breast J 11(4):236\u2013241. https:\/\/doi.org\/10.1111\/j.1075-122X.2005.21499.x","journal-title":"Breast J"},{"issue":"6","key":"4916_CR30","first-page":"673","volume":"57","author":"HF Dvorak","year":"1987","unstructured":"Dvorak HF, Harvey VS, Estrella P, Brown LF, McDonagh J, Dvorak AM (1987) Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest 57(6):673\u2013686","journal-title":"Lab Invest"},{"issue":"5","key":"4916_CR31","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1084\/jem.174.5.1275","volume":"174","author":"HF Dvorak","year":"1991","unstructured":"Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, Van de Water L, Senger DR (1991) Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J Exp Med 174(5):1275\u20131278","journal-title":"J Exp Med"},{"issue":"Pt 6","key":"4916_CR32","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1242\/jcs.108.6.2369","volume":"108","author":"WG Roberts","year":"1995","unstructured":"Roberts WG, Palade GE (1995) Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 108(Pt 6):2369\u20132379","journal-title":"J Cell Sci"},{"issue":"1","key":"4916_CR33","first-page":"59","volume":"149","author":"M Dellian","year":"1996","unstructured":"Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK (1996) Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor\/vascular permeability factor, and host microenvironment. Am J Pathol 149(1):59\u201371","journal-title":"Am J Pathol"},{"issue":"1","key":"4916_CR34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","volume":"18","author":"N Ferrara","year":"1997","unstructured":"Ferrara N, Davis-Smyth T (1997) The biology of vascular endothelial growth factor. Endocr Rev 18(1):4\u201325. https:\/\/doi.org\/10.1210\/edrv.18.1.0287","journal-title":"Endocr Rev"},{"issue":"2","key":"4916_CR35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/BF00666040","volume":"36","author":"M Toi","year":"1995","unstructured":"Toi M, Inada K, Suzuki H, Tominaga T (1995) Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res Treat 36(2):193\u2013204","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"4916_CR36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1158\/1055-9965.EPI-04-0490","volume":"14","author":"T Li","year":"2005","unstructured":"Li T, Sun L, Miller N, Nicklee T, Woo J, Hulse-Smith L, Tsao MS, Khokha R, Martin L, Boyd N (2005) The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol Biomark Prev 14(2):343\u2013349","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"4916_CR37","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1097\/00000478-198606000-00003","volume":"10","author":"TA Longacre","year":"1986","unstructured":"Longacre TA, Bartow SA (1986) A correlative morphologic study of human breast and endometrium in the menstrual cycle. Am J Surg Pathol 10:382\u2013393","journal-title":"Am J Surg Pathol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-018-4916-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4916-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4916-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T01:41:39Z","timestamp":1661823699000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-018-4916-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["4916"],"URL":"https:\/\/doi.org\/10.1007\/s10549-018-4916-6","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,23]]},"assertion":[{"value":"25 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Memorial Sloan Kettering Cancer Center institutional national research committee and with the 1964 Helsinki declaration and its later amendments. For this type of study formal consent is not required. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}