{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:16:06Z","timestamp":1792782966061,"version":"4.5.0"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/BioCARe\/01\/9701\/2013-14"],"award-info":[{"award-number":["BT\/BioCARe\/01\/9701\/2013-14"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Human Resource Development (IN)","award":["SG\/IITH\/F145\/2016-17\/SG-27"],"award-info":[{"award-number":["SG\/IITH\/F145\/2016-17\/SG-27"]}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Human Resource Development","doi-asserted-by":"publisher","award":["PhD fellowship"],"award-info":[{"award-number":["PhD fellowship"]}],"id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2017\/000242"],"award-info":[{"award-number":["ECR\/2017\/000242"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s10549-018-4970-0","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T03:45:09Z","timestamp":1537501509000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["T-Type voltage gated calcium channels: a target in breast cancer?"],"prefix":"10.1007","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-3427","authenticated-orcid":false,"given":"Anamika","family":"Bhargava","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"issue":"7","key":"4970_CR1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm1155","volume":"4","author":"MJ Berridge","year":"2003","unstructured":"Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4(7):517\u2013529. \n                    https:\/\/doi.org\/10.1038\/nrm1155","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"4970_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1080\/20014091074183","volume":"36","author":"E Carafoli","year":"2001","unstructured":"Carafoli E, Santella L, Branca D, Brini M (2001) Generation, control, and processing of cellular calcium signals. Crit Rev Biochem Mol Biol 36(2):107\u2013260. \n                    https:\/\/doi.org\/10.1080\/20014091074183","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"1","key":"4970_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1113\/jphysiol.2011.224592","volume":"590","author":"D Bowie","year":"2012","unstructured":"Bowie D (2012) Ligand-gated ion channels: from genes to behaviour. J Physiol 590(1):9\u201311. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2011.224592","journal-title":"J Physiol"},{"key":"4970_CR4","doi-asserted-by":"publisher","unstructured":"North RA (2016) P2X receptors. Philos Trans R Soc Lond B Biol Sci 371 (1700). \n                    https:\/\/doi.org\/10.1098\/rstb.2015.0427","DOI":"10.1098\/rstb.2015.0427"},{"issue":"28","key":"4970_CR5","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.2174\/138161206778522029","volume":"12","author":"AJ Thompson","year":"2006","unstructured":"Thompson AJ, Lummis SC (2006) 5-HT3 receptors. Curr Pharm Des 12(28):3615\u20133630","journal-title":"Curr Pharm Des"},{"issue":"2","key":"4970_CR6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S0006-3495(78)85489-7","volume":"22","author":"B Hille","year":"1978","unstructured":"Hille B (1978) Ionic channels in excitable membranes. Current problems and biophysical approaches. Biophys J 22(2):283\u2013294. \n                    https:\/\/doi.org\/10.1016\/S0006-3495(78)85489-7","journal-title":"Biophys J"},{"issue":"4","key":"4970_CR7","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","volume":"95","author":"M Prakriya","year":"2015","unstructured":"Prakriya M, Lewis RS (2015) Store-Operated calcium channels. Physiol Rev 95(4):1383\u20131436. \n                    https:\/\/doi.org\/10.1152\/physrev.00020.2014","journal-title":"Physiol Rev"},{"issue":"3","key":"4970_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","volume":"25","author":"EA Ertel","year":"2000","unstructured":"Ertel EA, Campbell KP, Harpold MM, Hofmann F, Mori Y, Perez-Reyes E, Schwartz A, Snutch TP, Tanabe T, Birnbaumer L, Tsien RW, Catterall WA (2000) Nomenclature of voltage-gated calcium channels. Neuron 25(3):533\u2013535","journal-title":"Neuron"},{"issue":"2","key":"4970_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.neulet.2010.08.085","volume":"486","author":"WA Catterall","year":"2010","unstructured":"Catterall WA (2010) Signaling complexes of voltage-gated sodium and calcium channels. Neurosci Lett 486(2):107\u2013116. \n                    https:\/\/doi.org\/10.1016\/j.neulet.2010.08.085","journal-title":"Neurosci Lett"},{"issue":"11","key":"4970_CR10","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.bbamcr.2006.08.049","volume":"1763","author":"I Bidaud","year":"2006","unstructured":"Bidaud I, Mezghrani A, Swayne LA, Monteil A, Lory P (2006) Voltage-gated calcium channels in genetic diseases. Biochim Biophys Acta 1763(11):1169\u20131174. \n                    https:\/\/doi.org\/10.1016\/j.bbamcr.2006.08.049","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"4970_CR11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.molmed.2010.01.005","volume":"16","author":"N Prevarskaya","year":"2010","unstructured":"Prevarskaya N, Skryma R, Shuba Y (2010) Ion channels and the hallmarks of cancer. Trends Mol Med 16(3):107\u2013121. \n                    https:\/\/doi.org\/10.1016\/j.molmed.2010.01.005","journal-title":"Trends Mol Med"},{"issue":"2","key":"4970_CR12","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.3892\/ol.2017.6457","volume":"14","author":"NN Phan","year":"2017","unstructured":"Phan NN, Wang CY, Chen CF, Sun Z, Lai MD, Lin YC (2017) Voltage-gated calcium channels: novel targets for cancer therapy. Oncol Lett 14(2):2059\u20132074. \n                    https:\/\/doi.org\/10.3892\/ol.2017.6457","journal-title":"Oncol Lett"},{"issue":"2","key":"4970_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ceca.2006.04.014","volume":"40","author":"LS Gray","year":"2006","unstructured":"Gray LS, Macdonald TL (2006) The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer. Cell Calcium 40(2):115\u2013120. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2006.04.014","journal-title":"Cell Calcium"},{"issue":"2","key":"4970_CR14","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ceca.2006.04.029","volume":"40","author":"A Panner","year":"2006","unstructured":"Panner A, Wurster RD (2006) T-type calcium channels and tumor proliferation. Cell Calcium 40(2):253\u2013259. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2006.04.029","journal-title":"Cell Calcium"},{"issue":"32","key":"4970_CR15","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.3748\/wjg.14.4984","volume":"14","author":"JT Taylor","year":"2008","unstructured":"Taylor JT, Zeng XB, Pottle JE, Lee K, Wang AR, Yi SG, Scruggs JA, Sikka SS, Li M (2008) Calcium signaling and T-type calcium channels in cancer cell cycling. World J Gastroenterol 14(32):4984\u20134991","journal-title":"World J Gastroenterol"},{"issue":"5","key":"4970_CR16","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1085\/jgp.65.5.617","volume":"65","author":"S Hagiwara","year":"1975","unstructured":"Hagiwara S, Ozawa S, Sand O (1975) Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish. J Gen Physiol 65(5):617\u2013644","journal-title":"J Gen Physiol"},{"issue":"1","key":"4970_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1152\/physrev.00018.2002","volume":"83","author":"E Perez-Reyes","year":"2003","unstructured":"Perez-Reyes E (2003) Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev 83(1):117\u2013161. \n                    https:\/\/doi.org\/10.1152\/physrev.00018.2002","journal-title":"Physiol Rev"},{"issue":"2","key":"4970_CR18","doi-asserted-by":"publisher","first-page":"162","DOI":"10.2174\/1874467208666150507110202","volume":"8","author":"F Hofmann","year":"2015","unstructured":"Hofmann F, Belkacemi A, Flockerzi V (2015) Emerging Alternative Functions for the Auxiliary Subunits of the Voltage-Gated Calcium Channels. Curr Mol Pharmacol 8(2):162\u2013168","journal-title":"Curr Mol Pharmacol"},{"issue":"2","key":"4970_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1527-3466.2005.tb00164.x","volume":"23","author":"M Li","year":"2005","unstructured":"Li M, Hansen JB, Huang L, Keyser BM, Taylor JT (2005) Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55\u20130396. Cardiovasc Drug Rev 23(2):173\u2013196","journal-title":"Cardiovasc Drug Rev"},{"issue":"6","key":"4970_CR20","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4161\/chan.4.6.14106","volume":"4","author":"SM Cain","year":"2010","unstructured":"Cain SM, Snutch TP (2010) Contributions of T-type calcium channel isoforms to neuronal firing. Channels (Austin) 4(6):475\u2013482. \n                    https:\/\/doi.org\/10.4161\/chan.4.6.14106","journal-title":"Channels (Austin)"},{"key":"4970_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1113\/jphysiol.1988.sp016916","volume":"395","author":"N Hagiwara","year":"1988","unstructured":"Hagiwara N, Irisawa H, Kameyama M (1988) Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol 395:233\u2013253","journal-title":"J Physiol"},{"issue":"6","key":"4970_CR22","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.bbamcr.2008.11.003","volume":"1793","author":"S Huc","year":"2009","unstructured":"Huc S, Monteil A, Bidaud I, Barbara G, Chemin J, Lory P (2009) Regulation of T-type calcium channels: signalling pathways and functional implications. Biochim Biophys Acta 1793(6):947\u2013952. \n                    https:\/\/doi.org\/10.1016\/j.bbamcr.2008.11.003","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"4970_CR23","doi-asserted-by":"publisher","first-page":"C1414","DOI":"10.1152\/ajpcell.00488.2009","volume":"298","author":"A Oguri","year":"2010","unstructured":"Oguri A, Tanaka T, Iida H, Meguro K, Takano H, Oonuma H, Nishimura S, Morita T, Yamasoba T, Nagai R, Nakajima T (2010) Involvement of CaV3.1 T-type calcium channels in cell proliferation in mouse preadipocytes. Am J Physiol Cell Physiol 298(6):C1414\u2013C1423. \n                    https:\/\/doi.org\/10.1152\/ajpcell.00488.2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"4970_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.yjmcc.2009.08.021","volume":"48","author":"K Ono","year":"2010","unstructured":"Ono K, Iijima T (2010) Cardiac T-type Ca(2+) channels in the heart. J Mol Cell Cardiol 48(1):65\u201370. \n                    https:\/\/doi.org\/10.1016\/j.yjmcc.2009.08.021","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"4970_CR25","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/j.bbamem.2012.07.031","volume":"1828","author":"N Weiss","year":"2013","unstructured":"Weiss N, Zamponi GW (2013) Control of low-threshold exocytosis by T-type calcium channels. Biochim Biophys Acta 1828(7):1579\u20131586. \n                    https:\/\/doi.org\/10.1016\/j.bbamem.2012.07.031","journal-title":"Biochim Biophys Acta"},{"issue":"18","key":"4970_CR26","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.2174\/138161206777585184","volume":"12","author":"MT Nelson","year":"2006","unstructured":"Nelson MT, Todorovic SM, Perez-Reyes E (2006) The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des 12(18):2189\u20132197","journal-title":"Curr Pharm Des"},{"key":"4970_CR27","doi-asserted-by":"publisher","unstructured":"Bourinet E, Francois A, Laffray S (2016) T-type calcium channels in neuropathic pain. Pain 157 Suppl 1:S15\u2013S22. \n                    https:\/\/doi.org\/10.1097\/j.pain.0000000000000469","DOI":"10.1097\/j.pain.0000000000000469"},{"issue":"3","key":"4970_CR28","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1158\/1535-7163.MCT-15-0456","volume":"15","author":"B Dziegielewska","year":"2016","unstructured":"Dziegielewska B, Casarez EV, Yang WZ, Gray LS, Dziegielewski J, Slack-Davis JK (2016) T-Type Ca2 + Channel Inhibition Sensitizes Ovarian Cancer to Carboplatin. Mol Cancer Ther 15(3):460\u2013470. \n                    https:\/\/doi.org\/10.1158\/1535-7163.MCT-15-0456","journal-title":"Mol Cancer Ther"},{"issue":"15","key":"4970_CR29","doi-asserted-by":"publisher","first-page":"10162","DOI":"10.1074\/jbc.M707159200","volume":"283","author":"F Gackiere","year":"2008","unstructured":"Gackiere F, Bidaux G, Delcourt P, Van Coppenolle F, Katsogiannou M, Dewailly E, Bavencoffe A, Van Chuoi-Mariot MT, Mauroy B, Prevarskaya N, Mariot P (2008) CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells. J Biol Chem 283(15):10162\u201310173. \n                    https:\/\/doi.org\/10.1074\/jbc.M707159200","journal-title":"J Biol Chem"},{"issue":"3","key":"4970_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2302\/kjm.59.84","volume":"59","author":"K Hayashi","year":"2010","unstructured":"Hayashi K, Homma K, Wakino S, Tokuyama H, Sugano N, Saruta T, Itoh H (2010) T-type Ca channel blockade as a determinant of kidney protection. Keio J Med 59(3):84\u201395","journal-title":"Keio J Med"},{"key":"4970_CR31","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13046-015-0171-4","volume":"34","author":"W Huang","year":"2015","unstructured":"Huang W, Lu C, Wu Y, Ouyang S, Chen Y (2015) T-type calcium channel antagonists, mibefradil and NNC-55-0396 inhibit cell proliferation and induce cell apoptosis in leukemia cell lines. J Exp Clin Cancer Res 34:54. \n                    https:\/\/doi.org\/10.1186\/s13046-015-0171-4","journal-title":"J Exp Clin Cancer Res"},{"issue":"5","key":"4970_CR32","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1111\/bjd.15121","volume":"176","author":"O Maiques","year":"2017","unstructured":"Maiques O, Macia A, Moreno S, Barcelo C, Santacana M, Vea A, Herreros J, Gatius S, Ortega E, Valls J, Chen BJ, Llobet-Navas D, Matias-Guiu X, Canti C, Marti RM (2017) Immunohistochemical analysis of T-type calcium channels in acquired melanocytic naevi and melanoma. Br J Dermatol 176(5):1247\u20131258. \n                    https:\/\/doi.org\/10.1111\/bjd.15121","journal-title":"Br J Dermatol"},{"issue":"1","key":"4970_CR33","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.canlet.2008.03.032","volume":"267","author":"JT Taylor","year":"2008","unstructured":"Taylor JT, Huang L, Pottle JE, Liu K, Yang Y, Zeng X, Keyser BM, Agrawal KC, Hansen JB, Li M (2008) Selective blockade of T-type Ca2 + channels suppresses human breast cancer cell proliferation. Cancer Lett 267(1):116\u2013124. \n                    https:\/\/doi.org\/10.1016\/j.canlet.2008.03.032","journal-title":"Cancer Lett"},{"issue":"18","key":"4970_CR34","first-page":"4535","volume":"59","author":"M Toyota","year":"1999","unstructured":"Toyota M, Ho C, Ohe-Toyota M, Baylin SB, Issa JP (1999) Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5\u2032 CpG island in human tumors. Cancer Res 59(18):4535\u20134541","journal-title":"Cancer Res"},{"issue":"5","key":"4970_CR35","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359\u2013E386. \n                    https:\/\/doi.org\/10.1002\/ijc.29210","journal-title":"Int J Cancer"},{"issue":"14","key":"4970_CR36","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1016\/j.ejca.2015.07.008","volume":"51","author":"A Gupta","year":"2015","unstructured":"Gupta A, Shridhar K, Dhillon PK (2015) A review of breast cancer awareness among women in India: cancer literate or awareness deficit? Eur J Cancer 51(14):2058\u20132066. \n                    https:\/\/doi.org\/10.1016\/j.ejca.2015.07.008","journal-title":"Eur J Cancer"},{"issue":"3","key":"4970_CR37","doi-asserted-by":"publisher","first-page":"412","DOI":"10.5306\/wjco.v5.i3.412","volume":"5","author":"O Yersal","year":"2014","unstructured":"Yersal O, Barutca S (2014) Biological subtypes of breast cancer: prognostic and therapeutic implications. World J Clin Oncol 5(3):412\u2013424. \n                    https:\/\/doi.org\/10.5306\/wjco.v5.i3.412","journal-title":"World J Clin Oncol"},{"key":"4970_CR38","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.yasu.2008.03.002","volume":"42","author":"T Bao","year":"2008","unstructured":"Bao T, Davidson NE (2008) Gene expression profiling of breast cancer. Adv Surg 42:249\u2013260","journal-title":"Adv Surg"},{"issue":"10","key":"4970_CR39","first-page":"2929","volume":"5","author":"X Dai","year":"2015","unstructured":"Dai X, Li T, Bai Z, Yang Y, Liu X, Zhan J, Shi B (2015) Breast cancer intrinsic subtype classification, clinical use and future trends. Am J Cancer Res 5(10):2929\u20132943","journal-title":"Am J Cancer Res"},{"issue":"4","key":"4970_CR40","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/annonc\/mdn675","volume":"20","author":"A Spitale","year":"2009","unstructured":"Spitale A, Mazzola P, Soldini D, Mazzucchelli L, Bordoni A (2009) Breast cancer classification according to immunohistochemical markers: clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland. Ann Oncol 20(4):628\u2013635. \n                    https:\/\/doi.org\/10.1093\/annonc\/mdn675","journal-title":"Ann Oncol"},{"issue":"2","key":"4970_CR41","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/path.2648","volume":"220","author":"B Weigelt","year":"2010","unstructured":"Weigelt B, Baehner FL, Reis-Filho JS (2010) The contribution of gene expression profiling to breast cancer classification, prognostication and prediction: a retrospective of the last decade. J Pathol 220(2):263\u2013280. \n                    https:\/\/doi.org\/10.1002\/path.2648","journal-title":"J Pathol"},{"issue":"7","key":"4970_CR42","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nrclinonc.2015.73","volume":"12","author":"D Zardavas","year":"2015","unstructured":"Zardavas D, Irrthum A, Swanton C, Piccart M (2015) Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol 12(7):381\u2013394. \n                    https:\/\/doi.org\/10.1038\/nrclinonc.2015.73","journal-title":"Nat Rev Clin Oncol"},{"key":"4970_CR43","doi-asserted-by":"crossref","unstructured":"Hendrick RE, Smith RA, Rutledge JH 3rd, Smart CR (1997) Benefit of screening mammography in women aged 40\u201349: a new meta-analysis of randomized controlled trials. J Natl Cancer Inst Monogr (22):87\u201392","DOI":"10.1093\/jncimono\/1997.22.87"},{"issue":"26","key":"4970_CR44","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1056\/NEJMoa052258","volume":"353","author":"G Collaborative","year":"2005","unstructured":"Breast International Group 1\u201398 Collaborative G, Thurlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Rabaglio M, Smith I, Wardley A, Price KN, Goldhirsch A (2005) A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med 353 (26):2747\u20132757. \n                    https:\/\/doi.org\/10.1056\/NEJMoa052258","journal-title":"N Engl J Med"},{"issue":"12","key":"4970_CR45","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/S1470-2045(10)70257-6","volume":"11","author":"J Cuzick","year":"2010","unstructured":"Cuzick J, Sestak I, Baum M, Buzdar A, Howell A, Dowsett M, Forbes JF, investigators AL (2010) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. Lancet Oncol 11(12):1135\u20131141. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(10)70257-6","journal-title":"Lancet Oncol"},{"issue":"11","key":"4970_CR46","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, Correa C, Cutter D, Gagliardi G, Gigante B, Jensen MB, Nisbet A, Peto R, Rahimi K, Taylor C, Hall P (2013) Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 368(11):987\u2013998. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1209825","journal-title":"N Engl J Med"},{"issue":"9472","key":"4970_CR47","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/S0140-6736(05)66544-0","volume":"365","author":"Early Breast Cancer Trialists","year":"2005","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative G (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472):1687\u20131717. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(05)66544-0","journal-title":"Lancet"},{"issue":"9804","key":"4970_CR48","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/S0140-6736(11)61629-2","volume":"378","author":"G Collaborative","year":"2011","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative G, Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, Gray R, Pierce L, Whelan T, Wang Y, Peto R (2011) Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet 378 (9804):1707\u20131716. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(11)61629-2","journal-title":"Lancet"},{"key":"4970_CR49","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1186\/1471-2407-11-260","volume":"11","author":"HG Kaplan","year":"2011","unstructured":"Kaplan HG, Malmgren JA, Atwood MK (2011) Increased incidence of myelodysplastic syndrome and acute myeloid leukemia following breast cancer treatment with radiation alone or combined with chemotherapy: a registry cohort analysis 1990\u20132005. BMC Cancer 11:260. \n                    https:\/\/doi.org\/10.1186\/1471-2407-11-260","journal-title":"BMC Cancer"},{"issue":"8","key":"4970_CR50","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/sj.bjc.6600859","volume":"88","author":"P Tassone","year":"2003","unstructured":"Tassone P, Tagliaferri P, Perricelli A, Blotta S, Quaresima B, Martelli ML, Goel A, Barbieri V, Costanzo F, Boland CR, Venuta S (2003) BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br J Cancer 88(8):1285\u20131291. \n                    https:\/\/doi.org\/10.1038\/sj.bjc.6600859","journal-title":"Br J Cancer"},{"issue":"19","key":"4970_CR51","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1056\/NEJMoa1209124","volume":"367","author":"S Verma","year":"2012","unstructured":"Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Dieras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K, Group ES (2012) Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 367(19):1783\u20131791. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1209124","journal-title":"N Engl J Med"},{"issue":"2","key":"4970_CR52","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7497\/j.issn.2095-3941.2015.0030","volume":"12","author":"HA Wahba","year":"2015","unstructured":"Wahba HA, El-Hadaad HA (2015) Current approaches in treatment of triple-negative breast cancer. Cancer Biol Med 12(2):106\u2013116. \n                    https:\/\/doi.org\/10.7497\/j.issn.2095-3941.2015.0030","journal-title":"Cancer Biol Med"},{"key":"4970_CR53","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.breast.2016.09.002","volume":"30","author":"K Velaei","year":"2016","unstructured":"Velaei K, Samadi N, Barazvan B, Soleimani Rad J (2016) Tumor microenvironment-mediated chemoresistance in breast cancer. Breast 30:92\u2013100. \n                    https:\/\/doi.org\/10.1016\/j.breast.2016.09.002","journal-title":"Breast"},{"issue":"11","key":"4970_CR54","first-page":"15184","volume":"8","author":"C Kim","year":"2015","unstructured":"Kim C, Lee J, Lee W, Kim A (2015) Changes in intrinsic subtype of breast cancer during tumor progression in the same patient. Int J Clin Exp Pathol 8(11):15184\u201315190","journal-title":"Int J Clin Exp Pathol"},{"key":"4970_CR55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000355896","volume":"41","author":"G Curigliano","year":"2014","unstructured":"Curigliano G, Criscitiello C (2014) Successes and limitations of targeted cancer therapy in breast cancer. Prog Tumor Res 41:15\u201335. \n                    https:\/\/doi.org\/10.1159\/000355896","journal-title":"Prog Tumor Res"},{"issue":"4","key":"4970_CR56","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/bph.12486","volume":"171","author":"I Azimi","year":"2014","unstructured":"Azimi I, Roberts-Thomson SJ, Monteith GR (2014) Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol 171(4):945\u2013960. \n                    https:\/\/doi.org\/10.1111\/bph.12486","journal-title":"Br J Pharmacol"},{"issue":"7","key":"4970_CR57","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00249-016-1144-z","volume":"45","author":"PJ Buchanan","year":"2016","unstructured":"Buchanan PJ, McCloskey KD (2016) CaV channels and cancer: canonical functions indicate benefits of repurposed drugs as cancer therapeutics. Eur Biophys J 45(7):621\u2013633. \n                    https:\/\/doi.org\/10.1007\/s00249-016-1144-z","journal-title":"Eur Biophys J"},{"issue":"3","key":"4970_CR58","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1161\/01.RES.0000256155.31133.49","volume":"100","author":"K Hayashi","year":"2007","unstructured":"Hayashi K, Wakino S, Sugano N, Ozawa Y, Homma K, Saruta T (2007) Ca2 + channel subtypes and pharmacology in the kidney. Circ Res 100(3):342\u2013353. \n                    https:\/\/doi.org\/10.1161\/01.RES.0000256155.31133.49","journal-title":"Circ Res"},{"issue":"4","key":"4970_CR59","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1111\/j.1476-5381.2012.01908.x","volume":"166","author":"G Santoni","year":"2012","unstructured":"Santoni G, Santoni M, Nabissi M (2012) Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy. Br J Pharmacol 166(4):1244\u20131246. \n                    https:\/\/doi.org\/10.1111\/j.1476-5381.2012.01908.x","journal-title":"Br J Pharmacol"},{"issue":"8","key":"4970_CR60","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1080\/10739680600930289","volume":"13","author":"C Zhou","year":"2006","unstructured":"Zhou C, Wu S (2006) T-type calcium channels in pulmonary vascular endothelium. Microcirculation 13(8):645\u2013656. \n                    https:\/\/doi.org\/10.1080\/10739680600930289","journal-title":"Microcirculation"},{"issue":"9026","key":"4970_CR61","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0140-6736(96)04277-8","volume":"348","author":"M Pahor","year":"1996","unstructured":"Pahor M, Guralnik JM, Ferrucci L, Corti MC, Salive ME, Cerhan JR, Wallace RB, Havlik RJ (1996) Calcium-channel blockade and incidence of cancer in aged populations. Lancet 348(9026):493\u2013497. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(96)04277-8","journal-title":"Lancet"},{"issue":"8","key":"4970_CR62","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8<1438::AID-CNCR11>3.0.CO;2-6","volume":"80","author":"AL Fitzpatrick","year":"1997","unstructured":"Fitzpatrick AL, Daling JR, Furberg CD, Kronmal RA, Weissfeld JL (1997) Use of calcium channel blockers and breast carcinoma risk in postmenopausal women. Cancer 80(8):1438\u20131447","journal-title":"Cancer"},{"issue":"10","key":"4970_CR63","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1001\/jamainternmed.2014.3867","volume":"174","author":"GJ Bergman","year":"2014","unstructured":"Bergman GJ, Khan S, Danielsson B, Borg N (2014) Breast cancer risk and use of calcium channel blockers using Swedish population registries. JAMA Intern Med 174(10):1700\u20131701. \n                    https:\/\/doi.org\/10.1001\/jamainternmed.2014.3867","journal-title":"JAMA Intern Med"},{"issue":"1","key":"4970_CR64","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s10549-015-3311-9","volume":"150","author":"EE Devore","year":"2015","unstructured":"Devore EE, Kim S, Ramin CA, Wegrzyn LR, Massa J, Holmes MD, Michels KB, Tamimi RM, Forman JP, Schernhammer ES (2015) Antihypertensive medication use and incident breast cancer in women. Breast Cancer Res Treat 150(1):219\u2013229. \n                    https:\/\/doi.org\/10.1007\/s10549-015-3311-9","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"4970_CR65","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10549-005-9091-x","volume":"97","author":"JP Fryzek","year":"2006","unstructured":"Fryzek JP, Poulsen AH, Lipworth L, Pedersen L, Norgaard M, McLaughlin JK, Friis S (2006) A cohort study of antihypertensive medication use and breast cancer among Danish women. Breast Cancer Res Treat 97(3):231\u2013236. \n                    https:\/\/doi.org\/10.1007\/s10549-005-9091-x","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"4970_CR66","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1001\/archinte.160.3.349","volume":"160","author":"CR Meier","year":"2000","unstructured":"Meier CR, Derby LE, Jick SS, Jick H (2000) Angiotensin-converting enzyme inhibitors, calcium channel blockers, and breast cancer. Arch Intern Med 160(3):349\u2013353","journal-title":"Arch Intern Med"},{"issue":"9","key":"4970_CR67","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1002\/(SICI)1097-0142(19981101)83:9<2003::AID-CNCR17>3.0.CO;2-3","volume":"83","author":"KB Michels","year":"1998","unstructured":"Michels KB, Rosner BA, Walker AM, Stampfer MJ, Manson JE, Colditz GA, Hennekens CH, Willett WC (1998) Calcium channel blockers, cancer incidence, and cancer mortality in a cohort of U.S. women: the nurses\u2019 health study. Cancer 83(9):2003\u20132007","journal-title":"Cancer"},{"issue":"5","key":"4970_CR68","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/01.HYP.29.5.1091","volume":"29","author":"JH Olsen","year":"1997","unstructured":"Olsen JH, Sorensen HT, Friis S, McLaughlin JK, Steffensen FH, Nielsen GL, Andersen M, Fraumeni JF Jr, Olsen J (1997) Cancer risk in users of calcium channel blockers. Hypertension 29(5):1091\u20131094","journal-title":"Hypertension"},{"issue":"13","key":"4970_CR69","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1001\/jama.279.13.1000","volume":"279","author":"L Rosenberg","year":"1998","unstructured":"Rosenberg L, Rao RS, Palmer JR, Strom BL, Stolley PD, Zauber AG, Warshauer ME, Shapiro S (1998) Calcium channel blockers and the risk of cancer. JAMA 279(13):1000\u20131004","journal-title":"JAMA"},{"issue":"10","key":"4970_CR70","first-page":"20425","volume":"9","author":"X Ye","year":"2016","unstructured":"Ye X, Du Q, Li H, Yu B, Zhai Q (2016) Calcium channel blockers and risk of breast cancer: a meta-analysis. Int J Clin Exp Med 9(10):20425\u201320431","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"4970_CR71","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13058-016-0720-6","volume":"18","author":"LE Wilson","year":"2016","unstructured":"Wilson LE, D\u2019Aloisio AA, Sandler DP, Taylor JA (2016) Long-term use of calcium channel blocking drugs and breast cancer risk in a prospective cohort of US and Puerto Rican women. Breast Cancer Res 18(1):61. \n                    https:\/\/doi.org\/10.1186\/s13058-016-0720-6","journal-title":"Breast Cancer Res"},{"issue":"2","key":"4970_CR72","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1124\/mol.62.2.210","volume":"62","author":"GE Bertolesi","year":"2002","unstructured":"Bertolesi GE, Shi C, Elbaum L, Jollimore C, Rozenberg G, Barnes S, Kelly ME (2002) The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol 62(2):210\u2013219","journal-title":"Mol Pharmacol"},{"issue":"6","key":"4970_CR73","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.ceca.2004.05.001","volume":"36","author":"LS Gray","year":"2004","unstructured":"Gray LS, Perez-Reyes E, Gomora JC, Haverstick DM, Shattock M, McLatchie L, Harper J, Brooks G, Heady T, Macdonald TL (2004) The role of voltage gated T-type Ca2 + channel isoforms in mediating \u201ccapacitative\u201d Ca2+ entry in cancer cells. Cell Calcium 36(6):489\u2013497. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2004.05.001","journal-title":"Cell Calcium"},{"issue":"1A","key":"4970_CR74","first-page":"35","volume":"26","author":"S Asaga","year":"2006","unstructured":"Asaga S, Ueda M, Jinno H, Kikuchi K, Itano O, Ikeda T, Kitajima M (2006) Identification of a new breast cancer-related gene by restriction landmark genomic scanning. Anticancer Res 26(1A):35\u201342","journal-title":"Anticancer Res"},{"issue":"4","key":"4970_CR75","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/elps.1150140145","volume":"14","author":"Y Hayashizaki","year":"1993","unstructured":"Hayashizaki Y, Hirotsune S, Okazaki Y, Hatada I, Shibata H, Kawai J, Hirose K, Watanabe S, Fushiki S, Wada S et al (1993) Restriction landmark genomic scanning method and its various applications. Electrophoresis 14(4):251\u2013258","journal-title":"Electrophoresis"},{"issue":"7","key":"4970_CR76","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1182\/blood-2003-07-2482","volume":"103","author":"M Yoshida","year":"2004","unstructured":"Yoshida M, Nosaka K, Yasunaga J, Nishikata I, Morishita K, Matsuoka M (2004) Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. Blood 103(7):2753\u20132760. \n                    https:\/\/doi.org\/10.1182\/blood-2003-07-2482","journal-title":"Blood"},{"issue":"14","key":"4970_CR77","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.1016\/j.bmcl.2004.05.011","volume":"14","author":"WF McCalmont","year":"2004","unstructured":"McCalmont WF, Heady TN, Patterson JR, Lindenmuth MA, Haverstick DM, Gray LS, Macdonald TL (2004) Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists. Bioorg Med Chem Lett 14(14):3691\u20133695. \n                    https:\/\/doi.org\/10.1016\/j.bmcl.2004.05.011","journal-title":"Bioorg Med Chem Lett"},{"issue":"7A","key":"4970_CR78","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4236\/jct.2013.47A006","volume":"4","author":"J Pottle","year":"2013","unstructured":"Pottle J, Sun C, Gray L, Li M (2013) Exploiting MCF-7 cells\u2019 calcium dependence with interlaced therapy. Journal of Cancer Therapy 4(7A):32\u201340. \n                    https:\/\/doi.org\/10.4236\/jct.2013.47A006","journal-title":"Journal of Cancer Therapy"},{"issue":"4","key":"4970_CR79","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00424-014-1444-z","volume":"466","author":"B Dziegielewska","year":"2014","unstructured":"Dziegielewska B, Gray LS, Dziegielewski J (2014) T-type calcium channels blockers as new tools in cancer therapies. Pflugers Arch 466(4):801\u2013810. \n                    https:\/\/doi.org\/10.1007\/s00424-014-1444-z","journal-title":"Pflugers Arch"},{"issue":"1","key":"4970_CR80","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3892\/ijo.2012.1422","volume":"41","author":"T Ohkubo","year":"2012","unstructured":"Ohkubo T, Yamazaki J (2012) T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int J Oncol 41(1):267\u2013275. \n                    https:\/\/doi.org\/10.3892\/ijo.2012.1422","journal-title":"Int J Oncol"},{"issue":"4","key":"4970_CR81","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ceca.2014.09.002","volume":"56","author":"E Ranzato","year":"2014","unstructured":"Ranzato E, Magnelli V, Martinotti S, Waheed Z, Cain SM, Snutch TP, Marchetti C, Burlando B (2014) Epigallocatechin-3-gallate elicits Ca2 + spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels. Cell Calcium 56(4):285\u2013295. \n                    https:\/\/doi.org\/10.1016\/j.ceca.2014.09.002","journal-title":"Cell Calcium"},{"issue":"2","key":"4970_CR82","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.molonc.2014.10.008","volume":"9","author":"MD Basson","year":"2015","unstructured":"Basson MD, Zeng B, Downey C, Sirivelu MP, Tepe JJ (2015) Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-beta. Mol Oncol 9(2):513\u2013526. \n                    https:\/\/doi.org\/10.1016\/j.molonc.2014.10.008","journal-title":"Mol Oncol"},{"key":"4970_CR83","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12935-016-0299-0","volume":"16","author":"E Pera","year":"2016","unstructured":"Pera E, Kaemmerer E, Milevskiy MJG, Yapa K, O\u2019Donnell JS, Brown MA, Simpson F, Peters AA, Roberts-Thomson SJ, Monteith GR (2016) The voltage gated Ca(2+)-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell Int 16:24. \n                    https:\/\/doi.org\/10.1186\/s12935-016-0299-0","journal-title":"Cancer Cell Int"},{"issue":"5","key":"4970_CR84","doi-asserted-by":"publisher","first-page":"339","DOI":"10.3109\/07357907.2011.568565","volume":"29","author":"W Li","year":"2011","unstructured":"Li W, Zhang SL, Wang N, Zhang BB, Li M (2011) Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation. Cancer Invest 29(5):339\u2013346. \n                    https:\/\/doi.org\/10.3109\/07357907.2011.568565","journal-title":"Cancer Invest"},{"issue":"3","key":"4970_CR85","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1158\/1541-7786.MCR-13-0485","volume":"12","author":"B Dziegielewska","year":"2014","unstructured":"Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J (2014) T-type Ca2 + channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells. Mol Cancer Res 12(3):348\u2013358. \n                    https:\/\/doi.org\/10.1158\/1541-7786.MCR-13-0485","journal-title":"Mol Cancer Res"},{"issue":"4","key":"4970_CR86","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00424-013-1427-5","volume":"466","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Wang H, Qian Z, Feng B, Zhao X, Jiang X, Tao J (2014) Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin. Pflugers Arch 466(4):811\u2013818. \n                    https:\/\/doi.org\/10.1007\/s00424-013-1427-5","journal-title":"Pflugers Arch"},{"issue":"7","key":"4970_CR87","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.bcp.2012.12.017","volume":"85","author":"NC Valerie","year":"2013","unstructured":"Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J (2013) Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells. Biochem Pharmacol 85(7):888\u2013897. \n                    https:\/\/doi.org\/10.1016\/j.bcp.2012.12.017","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"4970_CR88","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jcma.2015.05.002","volume":"78","author":"YS Chou","year":"2015","unstructured":"Chou YS, Yang MH (2015) Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy. J Chin Med Assoc 78(8):438\u2013445. \n                    https:\/\/doi.org\/10.1016\/j.jcma.2015.05.002","journal-title":"J Chin Med Assoc"},{"issue":"34","key":"4970_CR89","doi-asserted-by":"publisher","first-page":"55771","DOI":"10.18632\/oncotarget.9908","volume":"7","author":"J Deng","year":"2016","unstructured":"Deng J, Wang L, Chen H, Hao J, Ni J, Chang L, Duan W, Graham P, Li Y (2016) Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer. Oncotarget 7(34):55771\u201355788. \n                    https:\/\/doi.org\/10.18632\/oncotarget.9908","journal-title":"Oncotarget"},{"issue":"5","key":"4970_CR90","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nrd.2015.13","volume":"15","author":"F Marcucci","year":"2016","unstructured":"Marcucci F, Stassi G, De Maria R (2016) Epithelial-mesenchymal transition: a new target in anticancer drug discovery. Nat Rev Drug Discov 15(5):311\u2013325. \n                    https:\/\/doi.org\/10.1038\/nrd.2015.13","journal-title":"Nat Rev Drug Discov"},{"key":"4970_CR91","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1146\/annurev-pathol-012615-044438","volume":"11","author":"D Nassar","year":"2016","unstructured":"Nassar D, Blanpain C (2016) Cancer stem cells: basic concepts and therapeutic implications. Annu Rev Pathol 11:47\u201376. \n                    https:\/\/doi.org\/10.1146\/annurev-pathol-012615-044438","journal-title":"Annu Rev Pathol"},{"issue":"12","key":"4970_CR92","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1002\/sctm.17-0138","volume":"6","author":"F Papaccio","year":"2017","unstructured":"Papaccio F, Paino F, Regad T, Papaccio G, Desiderio V, Tirino V (2017) Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development. Stem Cells Transl Med 6(12):2115\u20132125. \n                    https:\/\/doi.org\/10.1002\/sctm.17-0138","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"4970_CR93","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrc.2017.118","volume":"18","author":"T Brabletz","year":"2018","unstructured":"Brabletz T, Kalluri R, Nieto MA, Weinberg RA (2018) EMT in cancer. Nat Rev Cancer 18(2):128\u2013134. \n                    https:\/\/doi.org\/10.1038\/nrc.2017.118","journal-title":"Nat Rev Cancer"},{"key":"4970_CR94","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s40169-015-0048-3","volume":"4","author":"S Heerboth","year":"2015","unstructured":"Heerboth S, Housman G, Leary M, Longacre M, Byler S, Lapinska K, Willbanks A, Sarkar S (2015) EMT and tumor metastasis. Clin Transl Med 4:6. \n                    https:\/\/doi.org\/10.1186\/s40169-015-0048-3","journal-title":"Clin Transl Med"},{"issue":"6","key":"4970_CR95","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.1152\/jn.2000.84.6.2975","volume":"84","author":"A Bringmann","year":"2000","unstructured":"Bringmann A, Schopf S, Reichenbach A (2000) Developmental regulation of calcium channel-mediated currents in retinal glial (Muller) cells. J Neurophysiol 84(6):2975\u20132983. \n                    https:\/\/doi.org\/10.1152\/jn.2000.84.6.2975","journal-title":"J Neurophysiol"},{"issue":"3","key":"4970_CR96","doi-asserted-by":"publisher","first-page":"C494","DOI":"10.1152\/ajpcell.00267.2011","volume":"302","author":"JA Rodriguez-Gomez","year":"2012","unstructured":"Rodriguez-Gomez JA, Levitsky KL, Lopez-Barneo J (2012) T-type Ca2+ channels in mouse embryonic stem cells: modulation during cell cycle and contribution to self-renewal. Am J Physiol Cell Physiol 302(3):C494\u2013C504. \n                    https:\/\/doi.org\/10.1152\/ajpcell.00267.2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"4970_CR97","doi-asserted-by":"publisher","first-page":"13297","DOI":"10.1038\/ncomms13297","volume":"7","author":"G Jacquemet","year":"2016","unstructured":"Jacquemet G, Baghirov H, Georgiadou M, Sihto H, Peuhu E, Cettour-Janet P, He T, Perala M, Kronqvist P, Joensuu H, Ivaska J (2016) L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling. Nat Commun 7:13297. \n                    https:\/\/doi.org\/10.1038\/ncomms13297","journal-title":"Nat Commun"},{"issue":"1","key":"4970_CR98","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1152\/jn.2002.88.1.196","volume":"88","author":"K Hirooka","year":"2002","unstructured":"Hirooka K, Bertolesi GE, Kelly ME, Denovan-Wright EM, Sun X, Hamid J, Zamponi GW, Juhasz AE, Haynes LW, Barnes S (2002) T-Type calcium channel alpha1G and alpha1H subunits in human retinoblastoma cells and their loss after differentiation. J Neurophysiol 88(1):196\u2013205. \n                    https:\/\/doi.org\/10.1152\/jn.2002.88.1.196","journal-title":"J Neurophysiol"},{"issue":"2","key":"4970_CR99","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/bjc.2012.231","volume":"107","author":"C Palmieri","year":"2012","unstructured":"Palmieri C, Rudraraju B, Monteverde M, Lattanzio L, Gojis O, Brizio R, Garrone O, Merlano M, Syed N, Lo Nigro C, Crook T (2012) Methylation of the calcium channel regulatory subunit alpha2delta-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas. Br J Cancer 107(2):375\u2013381. \n                    https:\/\/doi.org\/10.1038\/bjc.2012.231","journal-title":"Br J Cancer"},{"issue":"5","key":"4970_CR100","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1586\/era.13.34","volume":"13","author":"LS Gray","year":"2013","unstructured":"Gray LS, Schiff D, Macdonald TL (2013) A model for the regulation of T-type Ca(2+) channels in proliferation: roles in stem cells and cancer. Expert Rev Anticancer Ther 13(5):589\u2013595. \n                    https:\/\/doi.org\/10.1586\/era.13.34","journal-title":"Expert Rev Anticancer Ther"},{"issue":"4","key":"4970_CR101","first-page":"1002","volume":"60","author":"DM Haverstick","year":"2000","unstructured":"Haverstick DM, Heady TN, Macdonald TL, Gray LS (2000) Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry. Cancer Res 60(4):1002\u20131008","journal-title":"Cancer Res"},{"issue":"13","key":"4970_CR102","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1158\/0008-5472.CAN-16-2347","volume":"77","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Cruickshanks N, Yuan F, Wang B, Pahuski M, Wulfkuhle J, Gallagher I, Koeppel AF, Hatef S, Papanicolas C, Lee J, Bar EE, Schiff D, Turner SD, Petricoin EF, Gray LS, Abounader R (2017) Targetable T-type calcium channels drive glioblastoma. Cancer Res 77(13):3479\u20133490. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-16-2347","journal-title":"Cancer Res"},{"issue":"2","key":"4970_CR103","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ajpath.2013.04.029","volume":"183","author":"A Cove-Smith","year":"2013","unstructured":"Cove-Smith A, Mulgrew CJ, Rudyk O, Dutt N, McLatchie LM, Shattock MJ, Hendry BM (2013) Anti-proliferative actions of T-type calcium channel inhibition in Thy1 nephritis. Am J Pathol 183(2):391\u2013401. \n                    https:\/\/doi.org\/10.1016\/j.ajpath.2013.04.029","journal-title":"Am J Pathol"},{"issue":"2","key":"4970_CR104","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11060-012-0995-0","volume":"111","author":"ST Keir","year":"2013","unstructured":"Keir ST, Friedman HS, Reardon DA, Bigner DD, Gray LA (2013) Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model. J Neurooncol 111(2):97\u2013102. \n                    https:\/\/doi.org\/10.1007\/s11060-012-0995-0","journal-title":"J Neurooncol"},{"issue":"2","key":"4970_CR105","doi-asserted-by":"publisher","first-page":"e77","DOI":"10.1159\/000232590","volume":"113","author":"CJ Mulgrew","year":"2009","unstructured":"Mulgrew CJ, Cove-Smith A, McLatchie LM, Brooks G, Shattock MJ, Hendry BM (2009) Inhibition of human mesangial cell proliferation by targeting T-type calcium channels. Nephron Exp Nephrol 113(2):e77\u2013e88. \n                    https:\/\/doi.org\/10.1159\/000232590","journal-title":"Nephron Exp Nephrol"},{"issue":"10","key":"4970_CR106","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1089\/adt.2015.29014.ajkdrrr","volume":"13","author":"AJ Krouse","year":"2015","unstructured":"Krouse AJ, Gray L, Macdonald T, McCray J (2015) Repurposing and rescuing of mibefradil, an antihypertensive, for cancer: a case study. Assay Drug Dev Technol 13(10):650\u2013653. \n                    https:\/\/doi.org\/10.1089\/adt.2015.29014.ajkdrrr","journal-title":"Assay Drug Dev Technol"},{"issue":"6","key":"4970_CR107","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/neuonc\/nox020","volume":"19","author":"M Holdhoff","year":"2017","unstructured":"Holdhoff M, Ye X, Supko JG, Nabors LB, Desai AS, Walbert T, Lesser GJ, Read WL, Lieberman FS, Lodge MA, Leal J, Fisher JD, Desideri S, Grossman SA, Wahl RL, Schiff D (2017) Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas. Neuro Oncol 19(6):845\u2013852. \n                    https:\/\/doi.org\/10.1093\/neuonc\/nox020","journal-title":"Neuro Oncol"},{"issue":"11","key":"4970_CR108","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1016\/j.bmc.2005.03.004","volume":"13","author":"WF McCalmont","year":"2005","unstructured":"McCalmont WF, Patterson JR, Lindenmuth MA, Heady TN, Haverstick DM, Gray LS, Macdonald TL (2005) Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists\/antagonists. Bioorg Med Chem 13(11):3821\u20133839. \n                    https:\/\/doi.org\/10.1016\/j.bmc.2005.03.004","journal-title":"Bioorg Med Chem"},{"issue":"27","key":"4970_CR109","doi-asserted-by":"publisher","first-page":"11268","DOI":"10.1073\/pnas.1100869108","volume":"108","author":"F Marger","year":"2011","unstructured":"Marger F, Gelot A, Alloui A, Matricon J, Ferrer JF, Barrere C, Pizzoccaro A, Muller E, Nargeot J, Snutch TP, Eschalier A, Bourinet E, Ardid D (2011) T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci USA 108(27):11268\u201311273. \n                    https:\/\/doi.org\/10.1073\/pnas.1100869108","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"4970_CR110","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1124\/dmd.107.020115","volume":"36","author":"PH Bui","year":"2008","unstructured":"Bui PH, Quesada A, Handforth A, Hankinson O (2008) The mibefradil derivative NNC55-0396, a specific T-type calcium channel antagonist, exhibits less CYP3A4 inhibition than mibefradil. Drug Metab Dispos 36(7):1291\u20131299. \n                    https:\/\/doi.org\/10.1124\/dmd.107.020115","journal-title":"Drug Metab Dispos"},{"issue":"140","key":"4970_CR111","doi-asserted-by":"publisher","first-page":"140ra186","DOI":"10.1126\/scitranslmed.3003886","volume":"4","author":"SR Denmeade","year":"2012","unstructured":"Denmeade SR, Mhaka AM, Rosen DM, Brennen WN, Dalrymple S, Dach I, Olesen C, Gurel B, Demarzo AM, Wilding G, Carducci MA, Dionne CA, Moller JV, Nissen P, Christensen SB, Isaacs JT (2012) Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. Sci Transl Med 4(140):140ra186. \n                    https:\/\/doi.org\/10.1126\/scitranslmed.3003886","journal-title":"Sci Transl Med"},{"issue":"10 Pt B","key":"4970_CR112","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1016\/j.bbamem.2015.03.034","volume":"1848","author":"VP Kale","year":"2015","unstructured":"Kale VP, Amin SG, Pandey MK (2015) Targeting ion channels for cancer therapy by repurposing the approved drugs. Biochim Biophys Acta 1848(10 Pt B):2747\u20132755. \n                    https:\/\/doi.org\/10.1016\/j.bbamem.2015.03.034","journal-title":"Biochim Biophys Acta"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-018-4970-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-018-4970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T01:36:51Z","timestamp":1569029811000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-018-4970-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":112,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["4970"],"URL":"https:\/\/doi.org\/10.1007\/s10549-018-4970-0","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]},"assertion":[{"value":"24 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare having no financial competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}