{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:53:49Z","timestamp":1790816029635,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["CA148791"],"award-info":[{"award-number":["CA148791"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["CA047888"],"award-info":[{"award-number":["CA047888"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008560","name":"Breast Cancer Relief Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010174","name":"University of Colorado","doi-asserted-by":"publisher","award":["Colorado CTSI Grant Number UL1 TR001082"],"award-info":[{"award-number":["Colorado CTSI Grant Number UL1 TR001082"]}],"id":[{"id":"10.13039\/100010174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s10549-019-05268-y","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T15:17:38Z","timestamp":1557415058000},"page":"649-656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Adult weight gain accelerates the onset of breast cancer"],"prefix":"10.1007","volume":"176","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-9904","authenticated-orcid":false,"given":"Maria","family":"Azrad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy K.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Rock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Sedjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Y.","family":"Wolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Demark-Wahnefried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"5268_CR1","volume-title":"Global and regional estimates of the incidence and mortality for 38 cancers: GLOBOCAN 2018","author":"J Ferlay","year":"2018","unstructured":"Ferlay J, Colombet M, Soerjomataram I et al (2018) Global and regional estimates of the incidence and mortality for 38 cancers: GLOBOCAN 2018. International Agency for Research on Cancer\/World Health Organization, Lyon"},{"key":"5268_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11864-015-0341-9","volume":"16","author":"DS Chan","year":"2015","unstructured":"Chan DS, Norat T (2015) Obesity and breast cancer: not only a risk factor of the disease. Curr Treat Options Oncol 16:22. https:\/\/doi.org\/10.1007\/s11864-015-0341-9","journal-title":"Curr Treat Options Oncol"},{"key":"5268_CR3","unstructured":"World Health Organization. Obesity and overweight. [Web page]. http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight . Accessed 26 Oct 2018"},{"key":"5268_CR4","unstructured":"U.S. Department of Health and Human Services. Overweight and obesity statistics. [Web page]. https:\/\/www.niddk.nih.gov\/health-information\/health-statistics\/overweight-obesity . Accessed 8 Nov 2018"},{"key":"5268_CR5","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/sj.ijo.0802263","volume":"27","author":"TJ Sheehan","year":"2003","unstructured":"Sheehan TJ, DuBrava S, DeChello LM, Fang Z (2003) Rates of weight change for black and white Americans over a twenty year period. Int J Obes Relat Metab Disord 27:498\u2013504","journal-title":"Int J Obes Relat Metab Disord"},{"key":"5268_CR6","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1002\/oby.21573","volume":"24","author":"GR Dutton","year":"2016","unstructured":"Dutton GR, Kim Y, Jacobs DR Jr et al (2016) 25-Year weight gain in a racially balanced sample of U.S. adults: the CARDIA study. Obesity 24:1962\u20131968. https:\/\/doi.org\/10.1002\/oby.21573","journal-title":"Obesity"},{"key":"5268_CR7","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/jama.2017.7092","volume":"318","author":"Y Zheng","year":"2017","unstructured":"Zheng Y, Manson JE, Yuan C et al (2017) Associations of weight gain from early to middle adulthood with major health outcomes later in life. JAMA 318:255\u2013269","journal-title":"JAMA"},{"key":"5268_CR8","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1158\/1055-9965.EPI-03-0301","volume":"13","author":"HS Feigelson","year":"2004","unstructured":"Feigelson HS, Jonas CR, Teras LR, Thun MJ, Calle EE (2004) Weight gain, body mass index, hormone replacement therapy, and postmenopausal breast cancer in a large prospective study. Cancer Epidemiol Biomark Prev 13:220\u2013224","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"5268_CR9","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1001\/archinte.167.19.2091","volume":"167","author":"J Ahn","year":"2007","unstructured":"Ahn J, Schatzkin A, Lacey JV Jr, Albanes D, Ballard-Barbash R, Adams KF et al (2007) Adiposity, adult weight change, and postmenopausal breast cancer risk. Arch Intern Med 167:2091\u20132102","journal-title":"Arch Intern Med"},{"key":"5268_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1001\/jama.296.2.193","volume":"296","author":"AH Eliassen","year":"2006","unstructured":"Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE (2006) Adult weight change and risk of postmenopausal breast cancer. JAMA 296:193\u2013201","journal-title":"JAMA"},{"key":"5268_CR11","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1158\/1055-9965.EPI-04-0001","volume":"14","author":"M Harvie","year":"2005","unstructured":"Harvie M, Howell A, Vierkant RA, Kumar N, Cerhan JR, Kelemen LE et al (2005) Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women\u2019s health study. Cancer Epidemiol Biomark Prev 14:656\u2013661","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"5268_CR12","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/oby.22137","volume":"26","author":"NA Berger","year":"2018","unstructured":"Berger NA (2018) Young adult cancer: influence of the obesity pandemic. Obesity. 26:641\u2013650. https:\/\/doi.org\/10.1002\/oby.22137","journal-title":"Obesity."},{"issue":"18","key":"5268_CR13","doi-asserted-by":"publisher","first-page":"30267","DOI":"10.1016\/S2468-2667(18)30267-6","volume":"S2468\u20132667","author":"H Sung","year":"2019","unstructured":"Sung H, Siegel RL, Rosenberg PS, Jemal A (2019) Emerging cancer trends among young adults in the USA: analysis\u00a0of a population-based cancer registry. Lancet Public Health S2468\u20132667(18):30267\u201330276. https:\/\/doi.org\/10.1016\/S2468-2667(18)30267-6","journal-title":"Lancet Public Health"},{"key":"5268_CR14","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1001\/jama.2009.886","volume":"301","author":"D Li","year":"2009","unstructured":"Li D, Morris JS, Liu J, Hassan MM, Day RS, Bondy ML, Abbruzzese JL (2009) Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA 301:2553\u20132562","journal-title":"JAMA"},{"key":"5268_CR15","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cct.2012.12.003","volume":"34","author":"CL Rock","year":"2013","unstructured":"Rock CL, Byers TE, Colditz GA, Demark-Wahnefried W, Ganz PA, Wolin KY et al (2013) Reducing breast cancer recurrence with weight loss, a vanguard trial: the exercise and nutrition to enhance recovery and good health for you (ENERGY) trial. Contemp Clin Trials 34:282\u2013295","journal-title":"Contemp Clin Trials"},{"key":"5268_CR16","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","volume":"29","author":"L Desquilbet","year":"2010","unstructured":"Desquilbet L, Mariotti F (2010) Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 29:1037\u20131057","journal-title":"Stat Med"},{"key":"5268_CR17","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.2337\/dc17-2336","volume":"41","author":"A Stokes","year":"2018","unstructured":"Stokes A, Collins JM, Grant BF, Scamuffa RF, Hsiao CW, Johnston SS et al (2018) Obesity progression between young adulthood and midlife and incident diabetes: a retrospective cohort study of US adults. Diabetes Care 41:1025\u20131031","journal-title":"Diabetes Care"},{"key":"5268_CR18","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1002\/acr.20479","volume":"63","author":"MA DeMarco","year":"2011","unstructured":"DeMarco MA, Maynard JW, Huizinga MM et al (2011) Obesity and younger age at gout onset in a community-based cohort. Arthr Care Res 63:1108\u20131114","journal-title":"Arthr Care Res"},{"key":"5268_CR19","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1053\/j.ajkd.2013.10.055","volume":"63","author":"V Grubbs","year":"2014","unstructured":"Grubbs V, Lin F, Vittinghoff E et al (2014) Body mass index and early kidney function decline in young adults: a longitudinal analysis of the CARDIA (coronary artery risk development in young adults) study. Am J Kidney Dis 63:590\u2013597","journal-title":"Am J Kidney Dis"},{"key":"5268_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/jama.2013.7833","volume":"310","author":"JP Reis","year":"2013","unstructured":"Reis JP, Loria CM, Lewis CE et al (2013) Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. JAMA 310:280\u2013288","journal-title":"JAMA"},{"key":"5268_CR21","doi-asserted-by":"publisher","first-page":"e490","DOI":"10.1016\/S2468-2667(18)30139-7","volume":"3","author":"ST Nyberg","year":"2018","unstructured":"Nyberg ST, Batty GD, Pentti J et al (2018) Obesity and loss of disease-free years owing to major non-communicable diseases: a multicohort study. Lancet Public Health 3:e490\u2013e497. https:\/\/doi.org\/10.1016\/s2468-2667(18)30139-30147","journal-title":"Lancet Public Health"},{"key":"5268_CR22","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1158\/1940-6207.CAPR-12-0140","volume":"5","author":"SD Hursting","year":"2012","unstructured":"Hursting SD, Digiovanni J, Dannenberg AJ et al (2012) Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prev Res 5:1260\u20131272","journal-title":"Cancer Prev Res"},{"key":"5268_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gendis.2018.05.001","volume":"5","author":"Y Feng","year":"2018","unstructured":"Feng Y, Spezia M, Huang S et al (2018) Breast cancer development and progression: risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes Dis 5:77\u2013106","journal-title":"Genes Dis"},{"key":"5268_CR24","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/j.1467-789X.2008.00468.x","volume":"9","author":"VE Lemmens","year":"2008","unstructured":"Lemmens VE, Oenema A, Klepp KI, Henriksen HB, Brug J (2008) A systematic review of the evidence regarding efficacy of obesity prevention interventions among adults. Obes Rev 9:446\u2013455","journal-title":"Obes Rev"},{"key":"5268_CR25","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Diet, nutrition, physical activity and cancer: a global perspective. Continuous update project expert report 2018. http:\/\/dietandcancerreport.org\/"},{"key":"5268_CR26","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1471-2407-4-82","volume":"4","author":"W Han","year":"2004","unstructured":"Han W, Kim SW, Park IA et al (2004) Young age: an independent risk factor for disease-free survival in women with operable breast cancer. BMC Cancer 4:82","journal-title":"BMC Cancer"},{"key":"5268_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/s1368980018003002","volume":"19","author":"J Luo","year":"2018","unstructured":"Luo J, Thomson C, Hendryx M et al (2018) Accuracy of self-reported weight in the Women\u2019s Health Initiative. Public Health Nutr 19:1\u201310. https:\/\/doi.org\/10.1017\/s1368980018003002","journal-title":"Public Health Nutr"},{"key":"5268_CR28","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2352-4642(18)30022-1","volume":"2","author":"S Sawyer","year":"2018","unstructured":"Sawyer S, Azzopardi PS, Wickremarathne D et al (2018) The age of adolescence. Lancet Child Adolesc Health 2:223\u2013228","journal-title":"Lancet Child Adolesc Health"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-019-05268-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-019-05268-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-019-05268-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T20:59:18Z","timestamp":1721249958000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-019-05268-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["5268"],"URL":"https:\/\/doi.org\/10.1007\/s10549-019-05268-y","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]},"assertion":[{"value":"15 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have no disclosures to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}}]}}