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PAF reports personal fees from AstraZeneca, personal fees from Novartis, outside the submitted work; and Presentation of SOFT and TEXT trial results for Pfizer and Ipsen at overseas meeting without receiving honorarium. SC reports grants from NCIC, during the conduct of the study. GFF reports personal fees from Up To Date and Vaniam Group, non-financial support from Corcept, other from Merck, Syndax, 47 Inc, Sanofi, Astex EMD Sereno, Roche\/Genentech, Syros, Tesaro, Iovance, Sanofi, Ssermonix, Incyte, Compugen and Abbvie, outside the submitted work. AD reports personal fees from AstraZeneca, personal fees from Bayer, personal fees from Celgene, personal fees from Daichii-Sankyo, personal fees from Eisai, personal fees from Genentech, personal fees from Genomic Health, personal fees from Ipsen, personal fees from Lilly, grants and personal fees from Novartis, grants and personal fees from Pfizer, personal fees from Pierre Fabre, personal fees from Roche, personal fees from Seattle Genetics, outside the submitted work. MC reports personal fees from AstraZeneca, personal fees from Pierre Fabre, personal fees from Pfizer, personal fees from Novartis, personal fees from OBI Pharma, personal fees from Puma Biotechnology, personal fees from Celldex, outside the submitted work. RDG reports grants from Pfizer, grants from Ipsen, grants from AstraZeneca, during the conduct of the study; grants from Roche, grants from Merck, grants from Celgene, grants from Ferring, grants from Novartis, outside the submitted work. MMR reports grants and non-financial support from Pfizer, non-financial support and other from Ipsen, during the conduct of the study; grants and non-financial support from Research funding to the IBCSG (and\/or provision of drug supply for clinical trials) from Novartis, Pfizer, Ipsen, TerSera, Merck, Ferring, Pierre Fabre, Roche, AstraZeneca, grants from Bayer, grants and personal fees from Bristol-Myers Squibb, outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Ethics committees and appropriate national health authorities from each center approved the protocol, and all patients provided written informed consent as part of the informed consent for the main trial. This manuscript does not contain any individual person\u2019s data in any form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}