{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:43:49Z","timestamp":1793774629574,"version":"4.6.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1021608"],"award-info":[{"award-number":["APP1021608"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s10549-020-05863-4","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T14:03:33Z","timestamp":1597759413000},"page":"459-467","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Reduction of breast lymphoedema secondary to breast cancer: a randomised controlled exercise trial"],"prefix":"10.1007","volume":"184","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8024-8641","authenticated-orcid":false,"given":"S. L.","family":"Kilbreath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. C.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Degnim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Hackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. L.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"5863_CR1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10549-014-3110-8","volume":"147","author":"H Verbelen","year":"2014","unstructured":"Verbelen H, Gebruers N, Beyers T, De Monie AC, Tjalma W (2014) Breast edema in breast cancer patients following breast-conserving surgery and radiotherapy: a systematic review. Breast Cancer Res Treat 147:463\u2013471","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"5863_CR2","doi-asserted-by":"publisher","first-page":"pkz011","DOI":"10.1093\/jncics\/pkz011","volume":"3","author":"DA Young-Afat","year":"2019","unstructured":"Young-Afat DA, Gregorowitsch ML, van den Bongard DH, Burgmans I, van der Pol CC, Witkamp AJ et al (2019) Breast edema following breast-conserving surgery and radiotherapy: patient-reported prevalence, determinants, and effect on health-related quality of life. JNCI Cancer Spectr 3(2):pkz011","journal-title":"JNCI Cancer Spectr"},{"key":"5863_CR3","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1188\/13.CJON.325-331","volume":"17","author":"R Sierla","year":"2013","unstructured":"Sierla R, Lee TS, Black D, Kilbreath SL (2013) Lymphedema following breast cancer: regions affected, severity of symptoms, and benefits of treatment from the patients\u2019 perspective. Clin J Oncol Nurs 17:325\u2013331","journal-title":"Clin J Oncol Nurs"},{"key":"5863_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/jso.20065","volume":"86","author":"J Turner","year":"2004","unstructured":"Turner J, Hayes S, Reul-Hirche H (2004) Improving the physical status and quality of life of women treated for breast cancer: a pilot study of a structured exercise intervention. J Surg Oncol 86:141\u2013146","journal-title":"J Surg Oncol"},{"key":"5863_CR5","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1056\/NEJMoa0810118","volume":"361","author":"KH Schmitz","year":"2009","unstructured":"Schmitz KH, Ahmed RL, Troxel A, Cheville A, Smith R, Lewis-Grant L et al (2009) Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med 361:664\u2013673","journal-title":"N Engl J Med"},{"issue":"2","key":"5863_CR6","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.apmr.2015.09.012","volume":"97","author":"B Singh","year":"2016","unstructured":"Singh B, Disipio T, Peake J, Hayes SC (2016) Systematic review and meta-analysis of the effects of exercise for those with cancer-related lymphedema. Arch Phys Med Rehabil 97(2):302\u2013315","journal-title":"Arch Phys Med Rehabil"},{"key":"5863_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10549-018-4725-y","volume":"170","author":"FT Baumann","year":"2018","unstructured":"Baumann FT, Reike A, Reimer V, Schumann M, Hallek M, Taaffe DR et al (2018) Effects of physical exercise on breast cancer-related secondary lymphedema: a systematic review. Breast Cancer Res Treat 170:1\u201313","journal-title":"Breast Cancer Res Treat"},{"key":"5863_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/09638288.2018.1514663","volume":"42","author":"T Hasenoehrl","year":"2020","unstructured":"Hasenoehrl T, Keilani M, Palma S, Crevenna R (2020) Resistance exercise and breast cancer related lymphedema\u2014a systematic review update. Disabil Rehabil 42:26\u201335","journal-title":"Disabil Rehabil"},{"key":"5863_CR9","first-page":"338","volume":"17","author":"S Thomas","year":"1992","unstructured":"Thomas S, Reading J, Shephard RJ (1992) Revision of the Physical Activity Readiness Questionnaire (PAR-Q). Can J Sport Sci 17:338\u2013345","journal-title":"Can J Sport Sci"},{"key":"5863_CR10","doi-asserted-by":"publisher","unstructured":"Ward LC, Degnim AC, Dylke ES, Kilbreath SL (2020) Bioimpedance spectroscopy of the breast. Lymphat Res Biol. https:\/\/doi.org\/10.1089\/lrb.2019.0087","DOI":"10.1089\/lrb.2019.0087"},{"key":"5863_CR11","first-page":"502","volume-title":"Lymphedema: diagnosis and therapy","author":"LC Ward","year":"2008","unstructured":"Ward LC, Kilbreath S, Cornish BH (2008) Bioimpedance analysis for early detection of lymphedema. In: Weissieder H, Schuchhardt C (eds) Lymphedema: diagnosis and therapy, 4th edn. Viavital Verlag Gmbh Publ, Essen, pp 502\u2013517","edition":"4"},{"key":"5863_CR12","first-page":"320","volume":"15","author":"RE Gearhart","year":"2001","unstructured":"Gearhart RE, Goss FL, Lagally KM, Jakicic JM, Gallagher J, Robertson RJ (2001) Standardized scaling procedures for rating perceived exertion during resistance exercise. J Strength Cond Res 15:320\u2013325","journal-title":"J Strength Cond Res"},{"key":"5863_CR13","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365\u2013376","journal-title":"J Natl Cancer Inst"},{"key":"5863_CR14","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1200\/JCO.1995.13.5.1249","volume":"13","author":"MJ Hjermstad","year":"1995","unstructured":"Hjermstad MJ, Fossa SD, Bjordal K, Kaasa S (1995) Test\/retest study of the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire. J Clin Oncol 13:1249\u20131254","journal-title":"J Clin Oncol"},{"key":"5863_CR15","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s00520-015-2684-y","volume":"23","author":"SH Ridner","year":"2015","unstructured":"Ridner SH, Dietrich MS (2015) Development and validation of the lymphedema symptom and intensity survey-arm. Support Care Cancer 23:3103\u20133112","journal-title":"Support Care Cancer"},{"key":"5863_CR16","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3109\/07357900902918494","volume":"28","author":"SA Czerniec","year":"2010","unstructured":"Czerniec SA, Ward LC, Refshauge KM, Beith J, Lee MJ, York S et al (2010) Assessment of breast cancer-related arm lymphedema\u2014comparison of physical measurement methods and self-report. Cancer Investig 28:54\u201362","journal-title":"Cancer Investig"},{"key":"5863_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1089\/lrb.2010.0014","volume":"9","author":"LC Ward","year":"2011","unstructured":"Ward LC, Dylke E, Czerniec S, Isenring E, Kilbreath SL (2011) Confirmation of the reference impedance ratios used for assessment of breast cancer-related lymphedema by bioelectrical impedance spectroscopy. Lymphat Res Biol 9:47\u201351","journal-title":"Lymphat Res Biol"},{"key":"5863_CR18","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1089\/lrb.2016.0067","volume":"16","author":"ES Dylke","year":"2018","unstructured":"Dylke ES, Benincasa Nakagawa H, Lin L, Clarke JL, Kilbreath SL (2018) Reliability and diagnostic thresholds for ultrasound measurements of dermal thickness in breast lymphedema. Lymphat Res Biol 16:258\u2013262","journal-title":"Lymphat Res Biol"},{"key":"5863_CR19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1524-4741.2007.00420.x","volume":"13","author":"CR Wratten","year":"2007","unstructured":"Wratten CR, O\u2019Brien PC, Hamilton CS, Bill D, Kilmurray J, Denham JW (2007) Breast edema in patients undergoing breast-conserving treatment for breast cancer: assessment via high frequency ultrasound. Breast J 13:266\u2013273","journal-title":"Breast J"},{"key":"5863_CR20","unstructured":"Institute of Medical Illustrators (2007) IMI National Guidelines for clinical photography in wound management. https:\/\/imi.org.uk\/guidelines\/IMINatGuidelinesWoundManagement.pdf"},{"key":"5863_CR21","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1080\/07303084.1993.10606684","volume":"64","author":"M Brzycki","year":"1993","unstructured":"Brzycki M (1993) Strength testing\u2014predicting a one-rep max from reps-to-fatigue. J Phys Educ Recreat Dance 64:88\u201390","journal-title":"J Phys Educ Recreat Dance"},{"key":"5863_CR22","volume-title":"ACSM\u2019s guidelines for exercise testing and prescription","author":"American College of Sports Medicine","year":"2014","unstructured":"American College of Sports Medicine (2014) ACSM\u2019s guidelines for exercise testing and prescription, 9th edn. Lippincott Williams & Wilkins, Philadelphia","edition":"9"},{"key":"5863_CR23","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1007\/s00520-015-3001-5","volume":"24","author":"JM Lombard","year":"2016","unstructured":"Lombard JM, Zdenkowski N, Wells K, Beckmore C, Reaby L, Forbes JF et al (2016) Aromatase inhibitor induced musculoskeletal syndrome: a significant problem with limited treatment options. Support Care Cancer 24:2139\u20132146","journal-title":"Support Care Cancer"},{"key":"5863_CR24","doi-asserted-by":"publisher","first-page":"2656","DOI":"10.1519\/JSC.0000000000001355","volume":"30","author":"NL Nelson","year":"2016","unstructured":"Nelson NL (2016) Breast cancer-related lymphedema and resistance exercise: a systematic review. J Strength Cond Res 30:2656\u20132665","journal-title":"J Strength Cond Res"},{"key":"5863_CR25","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/10739680590900003","volume":"12","author":"D Zawieja","year":"2005","unstructured":"Zawieja D (2005) Lymphatic biology and the microcirculation: past, present and future. Microcirculation 12:141\u2013150","journal-title":"Microcirculation"},{"key":"5863_CR26","doi-asserted-by":"publisher","first-page":"5749","DOI":"10.1113\/JP272088","volume":"594","author":"JP Scallan","year":"2016","unstructured":"Scallan JP, Zawieja SD, Castorena-Gonzalez JA, Davis MJ (2016) Lymphatic pumping: mechanics, mechanisms and malfunction. J Physiol (Lond) 594:5749\u20135768","journal-title":"J Physiol (Lond)"},{"key":"5863_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.lfs.2018.09.043","volume":"211","author":"R-C Ji","year":"2018","unstructured":"Ji R-C (2018) Recent advances and new insights into muscular lymphangiogenesis in health and disease. Life Sci 211:261\u2013269","journal-title":"Life Sci"},{"key":"5863_CR28","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1748-1716.1977.tb10364.x","volume":"99","author":"A Engeset","year":"1977","unstructured":"Engeset A, Olszewski W, Jaeger PM, Sokolowski J, Theodorsen L (1977) Twenty-four hour variation in flow and composition of leg lymph in normal men. Acta Physiol Scand 99:140\u2013148","journal-title":"Acta Physiol Scand"},{"key":"5863_CR29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1113\/jphysiol.1987.sp016564","volume":"387","author":"JG McGeown","year":"1987","unstructured":"McGeown JG, McHale NG, Thornbury KD (1987) The role of external compression and movement in lymph propulsion in the sheep hind limb. J Physiol 387:83\u201393","journal-title":"J Physiol"},{"key":"5863_CR30","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1152\/jappl.1993.75.2.633","volume":"75","author":"G Coates","year":"1993","unstructured":"Coates G, O\u2019Brodovich H, Goeree G (1993) Hindlimb and lung lymph flows during prolonged exercise. J Appl Physiol 75:633\u2013638","journal-title":"J Appl Physiol"},{"key":"5863_CR31","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1245\/s10434-007-9709-9","volume":"15","author":"H Suami","year":"2008","unstructured":"Suami H, Pan W-R, Mann GB, Taylor GI (2008) The lymphatic anatomy of the breast and its implications for sentinel lymph node biopsy: a human cadaver study. Ann Surg Oncol 15:863\u2013871","journal-title":"Ann Surg Oncol"},{"key":"5863_CR32","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/srt.12116","volume":"20","author":"F Hacard","year":"2014","unstructured":"Hacard F, Machet L, Caille A, Tauveron V, Georgescou G, Rapeneau I et al (2014) Measurement of skin thickness and skin elasticity to evaluate the effectiveness of intensive decongestive treatment in patients with lymphoedema: a prospective study. Skin Res Technol 20:274\u2013281","journal-title":"Skin Res Technol"},{"key":"5863_CR33","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s11136-019-02337-z","volume":"29","author":"H Verbelen","year":"2020","unstructured":"Verbelen H, De Vrieze T, Van Soom T, Meirte J, Van Goethem M, Hufkens G et al (2020) Development and clinimetric properties of the Dutch Breast Edema Questionnaire (BrEQ-Dutch version) to diagnose the presence of breast edema in breast cancer patients. Qual Life Res 29:569\u2013578","journal-title":"Qual Life Res"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-05863-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-020-05863-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-05863-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T20:15:44Z","timestamp":1629231344000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-020-05863-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["5863"],"URL":"https:\/\/doi.org\/10.1007\/s10549-020-05863-4","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"25 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Author B consults to ImpediMed Ltd., a manufacturer of impedance devices. ImpediMed Ltd. was not involved in the conceptualisation, design or execution of this study, nor in any preparation of the manuscript. Authors A, C, D, E, F and G have no conflicts of interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were conducted in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and approved by Royal Prince Alfred Hospital Human Ethics Review Committee (Reference Number X12-0144 & HREC\/12\/RPAH\/239).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}