{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:58:42Z","timestamp":1790211522515,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea","award":["1020350"],"award-info":[{"award-number":["1020350"]}]},{"name":"Seoul National University Research Grant"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s10549-020-05875-0","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T05:02:43Z","timestamp":1602910963000},"page":"615-626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer"],"prefix":"10.1007","volume":"184","author":[{"given":"Eun Ji","family":"Sim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Pil","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choonghyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Joon","family":"Surh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokyung","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hyuk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Eon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ku Sang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cha Kyong","family":"Yom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5002-9707","authenticated-orcid":false,"given":"Sue K.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,17]]},"reference":[{"issue":"11","key":"5875_CR1","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO;2-Z","volume":"77","author":"EB Claus","year":"1996","unstructured":"Claus EB, Schildkraut JM, Thompson WD, Risch NJ (1996) The genetic attributable risk of breast and ovarian cancer. Cancer 77(11):2318\u20132324. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(19960601)77:11<2318:AID-CNCR21>3.0.CO;2-Z","journal-title":"Cancer"},{"issue":"1","key":"5875_CR2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1186\/s12885-016-2962-1","volume":"16","author":"G Arpino","year":"2016","unstructured":"Arpino G, Pensabene M, Condello C, Ruocco R, Cerillo I, Lauria R, Forestieri V, Giuliano M, De Angelis C, Montella M, Crispo A, De Placido S (2016) Tumor characteristics and prognosis in familial breast cancer. BMC Cancer 16(1):924. https:\/\/doi.org\/10.1186\/s12885-016-2962-1","journal-title":"BMC Cancer"},{"issue":"5","key":"5875_CR3","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1086\/375033","volume":"72","author":"A Antoniou","year":"2003","unstructured":"Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, Loman N, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tulinius H, Thorlacius S, Eerola H, Nevanlinna H, Syrjakoski K, Kallioniemi OP, Thompson D, Evans C, Peto J, Lalloo F, Evans DG, Easton DF (2003) Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72(5):1117\u20131130. https:\/\/doi.org\/10.1086\/375033","journal-title":"Am J Hum Genet"},{"issue":"8852","key":"5875_CR4","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/0140-6736(93)92468-9","volume":"341","author":"S Narod","year":"1993","unstructured":"Narod S, Lynch H, Conway T, Watson P, Feunteun J, Lenoir G (1993) Increasing incidence of breast cancer in family with BRCA1 mutation. Lancet 341(8852):1101\u20131102","journal-title":"Lancet"},{"issue":"3","key":"5875_CR5","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1054\/bjoc.2001.1873","volume":"85","author":"Q Dai","year":"2001","unstructured":"Dai Q, Shu XO, Jin F, Potter JD, Kushi LH, Teas J, Gao YT, Zheng W (2001) Population-based case-control study of soyfood intake and breast cancer risk in Shanghai. Br J Cancer 85(3):372\u2013378. https:\/\/doi.org\/10.1054\/bjoc.2001.1873","journal-title":"Br J Cancer"},{"issue":"7","key":"5875_CR6","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/ijc.23644","volume":"123","author":"T Suzuki","year":"2008","unstructured":"Suzuki T, Matsuo K, Tsunoda N, Hirose K, Hiraki A, Kawase T, Yamashita T, Iwata H, Tanaka H, Tajima K (2008) Effect of soybean on breast cancer according to receptor status: a case-control study in Japan. Int J Cancer 123(7):1674\u20131680. https:\/\/doi.org\/10.1002\/ijc.23644","journal-title":"Int J Cancer"},{"issue":"4","key":"5875_CR7","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1002\/ijc.28088","volume":"133","author":"K Wada","year":"2013","unstructured":"Wada K, Nakamura K, Tamai Y, Tsuji M, Kawachi T, Hori A, Takeyama N, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C (2013) Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study. Int J Cancer 133(4):952\u2013960. https:\/\/doi.org\/10.1002\/ijc.28088","journal-title":"Int J Cancer"},{"issue":"1","key":"5875_CR8","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/sj.bjc.6604448","volume":"99","author":"AH Wu","year":"2008","unstructured":"Wu AH, Koh WP, Wang R, Lee HP, Yu MC (2008) Soy intake and breast cancer risk in Singapore Chinese Health Study. Br J Cancer 99(1):196\u2013200. https:\/\/doi.org\/10.1038\/sj.bjc.6604448","journal-title":"Br J Cancer"},{"issue":"2","key":"5875_CR9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1349-7006.2009.01376.x","volume":"101","author":"C Zhang","year":"2010","unstructured":"Zhang C, Ho SC, Lin F, Cheng S, Fu J, Chen Y (2010) Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status. Cancer Sci 101(2):501\u2013507. https:\/\/doi.org\/10.1111\/j.1349-7006.2009.01376.x","journal-title":"Cancer Sci"},{"issue":"3","key":"5875_CR10","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10549-009-0354-9","volume":"118","author":"M Zhang","year":"2009","unstructured":"Zhang M, Yang H, Holman CD (2009) Dietary intake of isoflavones and breast cancer risk by estrogen and progesterone receptor status. Breast Cancer Res Treat 118(3):553\u2013563. https:\/\/doi.org\/10.1007\/s10549-009-0354-9","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"5875_CR11","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.3390\/molecules21010013","volume":"21","author":"A Uifalean","year":"2015","unstructured":"Uifalean A, Schneider S, Ionescu C, Lalk M, Iuga CA (2015) Soy isoflavones and breast cancer cell lines: molecular mechanisms and future perspectives. Molecules 21(1):E13. https:\/\/doi.org\/10.3390\/molecules21010013","journal-title":"Molecules"},{"issue":"6","key":"5875_CR12","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.3945\/ajcn.112.057760","volume":"98","author":"KP Ko","year":"2013","unstructured":"Ko KP, Kim SW, Ma SH, Park B, Ahn Y, Lee JW, Lee MH, Kang E, Kim LS, Jung Y, Cho YU, Lee B, Lin JH, Park SK (2013) Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study. Am J Clin Nutr 98(6):1493\u20131501. https:\/\/doi.org\/10.3945\/ajcn.112.057760","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"5875_CR13","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.clon.2010.11.007","volume":"23","author":"SA Han","year":"2011","unstructured":"Han SA, Park SK, Ahn SH, Lee MH, Noh DY, Kim LS, Noh WC, Jung Y, Kim KS, Kim SW, Korean Breast Cancer Study Group (2011) The Korean hereditary breast cancer (KOHBRA) study: protocols and interim report. Clin Oncol 23(7):434\u2013441. https:\/\/doi.org\/10.1016\/j.clon.2010.11.007","journal-title":"Clin Oncol"},{"issue":"3","key":"5875_CR14","first-page":"173","volume":"6","author":"Y-J Ahn","year":"2003","unstructured":"Ahn YJ, Lee JE, Paik HY, Lee HK, Jo IH, Kim KC (2003) Development of a semi-quantitative food frequency questionnaire based on dietary data from the Korea national health and nutrition examination survey. Nutr Sci 6(3):173\u2013184","journal-title":"Nutr Sci"},{"issue":"12","key":"5875_CR15","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1038\/sj.ejcn.1602657","volume":"61","author":"Y Ahn","year":"2007","unstructured":"Ahn Y, Kwon E, Shim JE, Park MK, Joo Y, Kimm K, Park C, Kim DH (2007) Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study. Eur J Clin Nutr 61(12):1435\u20131441. https:\/\/doi.org\/10.1038\/sj.ejcn.1602657","journal-title":"Eur J Clin Nutr"},{"key":"5875_CR16","volume-title":"Food values","author":"The Korean Nutrition Society","year":"2009","unstructured":"The Korean Nutrition Society (2009) Food values. The Korean Nutrition Society, Seoul"},{"issue":"1","key":"5875_CR17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12874-019-0738-4","volume":"19","author":"Y Chen","year":"2019","unstructured":"Chen Y, Huang J, He X, Gao Y, Mahara G, Lin Z, Zhang J (2019) A novel approach to determine two optimal cut-points of a continuous predictor with a U-shaped relationship to hazard ratio in survival data: simulation and application. BMC Med Res Methodol 19(1):96. https:\/\/doi.org\/10.1186\/s12874-019-0738-4","journal-title":"BMC Med Res Methodol"},{"issue":"8","key":"5875_CR18","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","volume":"22","author":"A Goldhirsch","year":"2011","unstructured":"Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thurlimann B, Senn HJ, Panel M (2011) Strategies for subtypes\u2013dealing with the diversity of breast cancer: highlights of the St Gallen. International expert consensus on the primary therapy of early breast cancer 2011. Ann Oncol 22(8):1736\u20131747. https:\/\/doi.org\/10.1093\/annonc\/mdr304","journal-title":"Ann Oncol"},{"issue":"6","key":"5875_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3961\/jpmph.17.152","volume":"50","author":"SH Jeong","year":"2017","unstructured":"Jeong SH, An YS, Choi JY, Park B, Kang D, Lee MH, Han W, Noh DY, Yoo KY, Park SK (2017) Risk reduction of breast cancer by childbirth, breastfeeding, and their interaction in Korean women: heterogeneous effects across menopausal status, hormone receptor status, and pathological subtypes. J Prev Med Public Health 50(6):401\u2013410. https:\/\/doi.org\/10.3961\/jpmph.17.152","journal-title":"J Prev Med Public Health"},{"issue":"4","key":"5875_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pathol.2017.03.002","volume":"49","author":"MG Keeney","year":"2017","unstructured":"Keeney MG, Couch FJ, Visscher DW, Lindor NM (2017) Non-BRCA familial breast cancer: review of reported pathology and molecular findings. Pathology 49(4):363\u2013370. https:\/\/doi.org\/10.1016\/j.pathol.2017.03.002","journal-title":"Pathology"},{"issue":"60","key":"5875_CR21","doi-asserted-by":"publisher","first-page":"102110","DOI":"10.18632\/oncotarget.22193","volume":"8","author":"B Park","year":"2017","unstructured":"Park B, Hopper JL, Win AK, Dowty JG, Sung HK, Ahn C, Kim SW, Lee MH, Lee J, Lee JW, Kang E, Yu JH, Kim KS, Moon BI, Han W, Noh DY, Park SK, KOHBRA Study Group (2017) Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers. Oncotarget 8(60):102110\u2013102118. https:\/\/doi.org\/10.18632\/oncotarget.22193","journal-title":"Oncotarget"},{"issue":"2","key":"5875_CR22","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1158\/1055-9965.EPI-08-0546","volume":"18","author":"AC Antoniou","year":"2009","unstructured":"Antoniou AC, Rookus M, Andrieu N, Brohet R, Chang-Claude J, Peock S, Cook M, Evans DG, Eeles R, EMBRACE, Nogues C, Faivre L, Gesta P, GENEPSO, van Leeuwen FE, Ausems MG, Osorio A, GEO-HEBON, Caldes T, Simard J, Lubinski J, Gerdes AM, Olah E, Furhauser C, Olsson H, Arver B, Radice P, Easton DF, Goldgar DE (2009) Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1\/2 Carrier Cohort Study. Cancer Epidemiol Biomarkers Prev 18(2):601\u2013610. https:\/\/doi.org\/10.1158\/1055-9965.EPI-08-0546","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"5875_CR23","doi-asserted-by":"publisher","first-page":"pky023","DOI":"10.1093\/jncics\/pky023","volume":"2","author":"LH Schrijver","year":"2018","unstructured":"Schrijver LH, Olsson H, Phillips KA, Terry MB, Goldgar DE, Kast K, Engel C, Mooij TM, Adlard J, Barrowdale D, Davidson R, Eeles R, Ellis S, Evans DG, Frost D, Izatt L, Porteous ME, Side LE, Walker L, Berthet P, Bonadona V, Leroux D, Mouret-Fourme E, Venat-Bouvet L, Buys SS, Southey MC, John EM, Chung WK, Daly MB, Bane A, van Asperen CJ, Gomez Garcia EB, Mourits MJE, van Os TAM, Roos-Blom MJ, Friedlander ML, McLachlan SA, Singer CF, Tan YY, Foretova L, Navratilova M, Gerdes AM, Caldes T, Simard J, Olah E, Jakubowska A, Arver B, Osorio A, Nogues C, Andrieu N, Easton DF, van Leeuwen FE, Hopper JL, Milne RL, Antoniou AC, Rookus MA, EMBRACE, GENEPSO, BCFR, HEBON, kConFab, IBCCS (2018) Oral contraceptive use and breast cancer risk: retrospective and prospective analyses from a BRCA1 and BRCA2 mutation carrier cohort study. JNCI Cancer Spectr 2(2):pky023. https:\/\/doi.org\/10.1093\/jncics\/pky023","journal-title":"JNCI Cancer Spectr"},{"issue":"1","key":"5875_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/gepi.20074","volume":"29","author":"AC Antoniou","year":"2005","unstructured":"Antoniou AC, Goldgar DE, Andrieu N, Chang-Claude J, Brohet R, Rookus MA, Easton DF (2005) A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet Epidemiol 29(1):1\u201311. https:\/\/doi.org\/10.1002\/gepi.20074","journal-title":"Genet Epidemiol"},{"issue":"408","key":"5875_CR25","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1080\/01621459.1989.10478874","volume":"84","author":"DY Lin","year":"1989","unstructured":"Lin DY, Wei LJ (1989) The robust inference for the cox proportional hazards model. J Am Stat Assoc 84(408):1074\u20131078. https:\/\/doi.org\/10.1080\/01621459.1989.10478874","journal-title":"J Am Stat Assoc"},{"issue":"2","key":"5875_CR26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/sim.4780130206","volume":"13","author":"WW Piegorsch","year":"1994","unstructured":"Piegorsch WW, Weinberg CR, Taylor JA (1994) Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med 13(2):153\u2013162","journal-title":"Stat Med"},{"issue":"1","key":"5875_CR27","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.bjc.6604145","volume":"98","author":"AH Wu","year":"2008","unstructured":"Wu AH, Yu MC, Tseng CC, Pike MC (2008) Epidemiology of soy exposures and breast cancer risk. Br J Cancer 98(1):9\u201314. https:\/\/doi.org\/10.1038\/sj.bjc.6604145","journal-title":"Br J Cancer"},{"issue":"2","key":"5875_CR28","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s10549-010-1270-8","volume":"125","author":"JY Dong","year":"2011","unstructured":"Dong JY, Qin LQ (2011) Soy isoflavones consumption and risk of breast cancer incidence or recurrence: a meta-analysis of prospective studies. Breast Cancer Res Treat 125(2):315\u2013323. https:\/\/doi.org\/10.1007\/s10549-010-1270-8","journal-title":"Breast Cancer Res Treat"},{"issue":"9","key":"5875_CR29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/ejcn.2010.95","volume":"64","author":"YA Cho","year":"2010","unstructured":"Cho YA, Kim J, Park KS, Lim SY, Shin A, Sung MK, Ro J (2010) Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. Eur J Clin Nutr 64(9):924\u2013932. https:\/\/doi.org\/10.1038\/ejcn.2010.95","journal-title":"Eur J Clin Nutr"},{"issue":"4","key":"5875_CR30","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1002\/ijc.30117","volume":"139","author":"ML Baglia","year":"2016","unstructured":"Baglia ML, Zheng W, Li H, Yang G, Gao J, Gao YT, Shu XO (2016) The association of soy food consumption with the risk of subtype of breast cancers defined by hormone receptor and HER2 status. Int J Cancer 139(4):742\u2013748. https:\/\/doi.org\/10.1002\/ijc.30117","journal-title":"Int J Cancer"},{"issue":"2","key":"5875_CR31","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s10549-008-0168-1","volume":"116","author":"M Iwasaki","year":"2009","unstructured":"Iwasaki M, Hamada GS, Nishimoto IN, Netto MM, Motola J Jr, Laginha FM, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Kobayashi M, Ishihara J, Yamamoto S, Hanaoka T, Tsugane S (2009) Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Breast Cancer Res Treat 116(2):401\u2013411. https:\/\/doi.org\/10.1007\/s10549-008-0168-1","journal-title":"Breast Cancer Res Treat"},{"key":"5875_CR32","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.3389\/fphar.2019.01336","volume":"10","author":"HS Tuli","year":"2019","unstructured":"Tuli HS, Tuorkey MJ, Thakral F, Sak K, Kumar M, Sharma AK, Sharma U, Jain A, Aggarwal V, Bishayee A (2019) Molecular mechanisms of action of genistein in cancer: recent advances. Front Pharmacol 10:1336. https:\/\/doi.org\/10.3389\/fphar.2019.01336","journal-title":"Front Pharmacol"},{"issue":"4","key":"5875_CR33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.15430\/JCP.2019.24.4.197","volume":"24","author":"GY Kim","year":"2019","unstructured":"Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK, Surh YJ (2019) Genistein inhibits proliferation of BRCA1 mutated breast cancer cells: the GPR30-Akt axis as a potential target. J Cancer Prev 24(4):197\u2013207. https:\/\/doi.org\/10.15430\/JCP.2019.24.4.197","journal-title":"J Cancer Prev"},{"issue":"3","key":"5875_CR34","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3892\/or_00000680","volume":"23","author":"DJ Bernard-Gallon","year":"2010","unstructured":"Bernard-Gallon DJ, Satih S, Chalabi N, Rabiau N, Bosviel R, Fontana L, Bignon YJ (2010) Phytoestrogens regulate the expression of genes involved in different biological processes in BRCA2 knocked down MCF-7, MDA-MB-231 and MCF-10a cell lines. Oncol Rep 23(3):647\u2013653. https:\/\/doi.org\/10.3892\/or_00000680","journal-title":"Oncol Rep"},{"key":"5875_CR35","doi-asserted-by":"publisher","unstructured":"Mavaddat N, Barrowdale D, Andrulis IL, Domchek SM, Eccles D, Nevanlinna H, Ramus SJ, Spurdle A, Robson M, Sherman M, Mulligan AM, Couch FJ, Engel C, McGuffog L, Healey S, Sinilnikova OM, Southey MC, Terry MB, Goldgar D, O\u2019Malley F, John EM, Janavicius R, Tihomirova L, Hansen TV, Nielsen FC, Osorio A, Stavropoulou A, Benitez J, Manoukian S, Peissel B, Barile M, Volorio S, Pasini B, Dolcetti R, Putignano AL, Ottini L, Radice P, Hamann U, Rashid MU, Hogervorst FB, Kriege M, van der Luijt RB, HEBON, Peock S, Frost D, Evans DG, Brewer C, Walker L, Rogers MT, Side LE, Houghton C, EMBRACE, Weaver J, Godwin AK, Schmutzler RK, Wappenschmidt B, Meindl A, Kast K, Arnold N, Niederacher D, Sutter C, Deissler H, Gadzicki D, Preisler-Adams S, Varon-Mateeva R, Schonbuchner I, Gevensleben H, Stoppa-Lyonnet D, Belotti M, Barjhoux L, GEMO Study Collaborators, Isaacs C, Peshkin BN, Caldes T, de la Hoya M, Canadas C, Heikkinen T, Heikkila P, Aittomaki K, Blanco I, Lazaro C, Brunet J, Agnarsson BA, Arason A, Barkardottir RB, Dumont M, Simard J, Montagna M, Agata S, D\u2019Andrea E, Yan M, Fox S, kConFab Investigators, Rebbeck TR, Rubinstein W, Tung N, Garber JE, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Szabo C, Offit K, Sakr R, Gaudet MM, Singer CF, Tea MK, Rappaport C, Mai PL, Greene MH, Sokolenko A, Imyanitov E, Toland AE, Senter L, Sweet K, Thomassen M, Gerdes AM, Kruse T, Caligo M, Aretini P, Rantala J, von Wachenfeld A, Henriksson K, SWE-BRCA Collaborators, Steele L, Neuhausen SL, Nussbaum R, Beattie M, Odunsi K, Sucheston L, Gayther SA, Nathanson K, Gross J, Walsh C, Karlan B, Chenevix-Trench G, Easton DF, Antoniou AC, Consortium of Investigators of Modifiers of BRCA1\/2 (2012) Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1\/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 21(1):134\u2013147. https:\/\/doi.org\/10.1158\/1055-9965.EPI-11-0775","DOI":"10.1158\/1055-9965.EPI-11-0775"},{"issue":"4","key":"5875_CR36","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4048\/jbc.2013.16.4.357","volume":"16","author":"H Kim","year":"2013","unstructured":"Kim H, Choi DH (2013) Distribution of BRCA1 and BRCA2 mutations in Asian patients with breast cancer. J Breast Cancer 16(4):357\u2013365. https:\/\/doi.org\/10.4048\/jbc.2013.16.4.357","journal-title":"J Breast Cancer"},{"issue":"2","key":"5875_CR37","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.nutres.2013.12.002","volume":"34","author":"MK Virk-Baker","year":"2014","unstructured":"Virk-Baker MK, Barnes S, Krontiras H, Nagy TR (2014) S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy. Nutr Res 34(2):116\u2013125. https:\/\/doi.org\/10.1016\/j.nutres.2013.12.002","journal-title":"Nutr Res"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-05875-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10549-020-05875-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-05875-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T01:19:36Z","timestamp":1634433576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10549-020-05875-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,17]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["5875"],"URL":"https:\/\/doi.org\/10.1007\/s10549-020-05875-0","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,17]]},"assertion":[{"value":"27 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedure performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was registered at clinicaltrials.gov as NCT00595348, and approved by the Institutional Review Boards of Seoul National University (IRB number: C-0709\u2013050-219) and all ethics committees of each participating centers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}