{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:48:42Z","timestamp":1784252922535,"version":"3.55.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s10549-020-06005-6","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T15:03:32Z","timestamp":1605711812000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A phase I safety study of topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia"],"prefix":"10.1007","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-3710","authenticated-orcid":false,"given":"Mario E.","family":"Lacouture","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy","family":"Dion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Ravipaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin J.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khampaseuth","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Grund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ely","family":"Benaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikunj","family":"Tanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"DiTommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niven R.","family":"Narain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangaprasad","family":"Sarangarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elder","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari B.","family":"Goldfarb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"issue":"4","key":"6005_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1097\/SPC.0b013e3283409280","volume":"4","author":"RM Tr\u00fceb","year":"2010","unstructured":"Tr\u00fceb RM (2010) Chemotherapy-induced alopecia. Curr Opin Support Palliat Care 4(4):281\u2013284","journal-title":"Curr Opin Support Palliat Care"},{"issue":"4","key":"6005_CR2","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.7314\/APJCP.2012.13.4.1383","volume":"13","author":"IR Kim","year":"2012","unstructured":"Kim IR, Cho J, Choi EK et al (2012) Perception, attitudes, prepardedness and experience of chemotherapy-induced alopecia among breast cancer patients: a qualitative study. Asian Pac J Cancer Prev 13(4):1383\u20131388","journal-title":"Asian Pac J Cancer Prev"},{"issue":"11","key":"6005_CR3","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1007\/s11095-006-9105-3","volume":"23","author":"J Wang","year":"2006","unstructured":"Wang J, Lu Z, Au JL (2006) Protection against chemotherapy-induced alopecia. Pharm Res 23(11):2505\u20132514","journal-title":"Pharm Res"},{"issue":"8","key":"6005_CR4","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1001\/jamaoncol.2017.1026","volume":"3","author":"H West","year":"2017","unstructured":"West H (2017) Chemotherapy-induced hair loss (alopecia). JAMA Oncol 3(8):1147","journal-title":"JAMA Oncol"},{"issue":"3","key":"6005_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1177\/030089160409000304","volume":"90","author":"D Lombardi","year":"2004","unstructured":"Lombardi D, Crivellari D, Scuderi C et al (2004) Long-term, weekly one-hour infusion of paclitaxel in patients with metastatic breast cancer: a phase II monoinstitutional study. Tumori 90(3):285\u2013288","journal-title":"Tumori"},{"issue":"3","key":"6005_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s10549-006-9306-9","volume":"101","author":"G Gasparini","year":"2007","unstructured":"Gasparini G, Gion M, Mariani L et al (2007) Randomized Phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer. Breast Cancer Res Treat 101(3):355\u2013365","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"6005_CR7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1634\/theoncologist.2018-0184","volume":"24","author":"D Kang","year":"2019","unstructured":"Kang D, Kim IR, Choi EK et al (2019) Permanent chemotherapy-induced alopecia in patients with breast cancer: a 3-year prospective cohort study. Oncologist 24(3):414\u2013420","journal-title":"Oncologist"},{"issue":"6","key":"6005_CR8","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1001\/jama.2016.20939","volume":"317","author":"J Nangia","year":"2017","unstructured":"Nangia J, Wang T, Osborne C et al (2017) Effect of a scalp cooling device on alopecia in women undergoing chemotherapy for breast cancer: the SCALP randomized clinical trial. JAMA 317(6):596\u2013605","journal-title":"JAMA"},{"issue":"3","key":"6005_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1200\/JOP.17.00038","volume":"14","author":"M Kruse","year":"2018","unstructured":"Kruse M, Abraham J (2018) Management of chemotherapy-induced alopecia with scalp cooling. J Oncol Pract 14(3):149\u2013154","journal-title":"J Oncol Pract"},{"issue":"1","key":"6005_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1046\/j.1523-1747.2002.01644.x","volume":"118","author":"Z Xie","year":"2002","unstructured":"Xie Z, Komuves L, Yu QC et al (2002) Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 118(1):11\u201316","journal-title":"J Invest Dermatol"},{"issue":"2","key":"6005_CR11","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/ki.2010.17","volume":"78","author":"A Verstuyf","year":"2010","unstructured":"Verstuyf A, Carmeliet G, Bouillon R, Mathieu C (2010) Vitamin D: a pleiotropic hormone. Kidney Int 78(2):140\u2013145","journal-title":"Kidney Int"},{"issue":"1","key":"6005_CR12","first-page":"53","volume":"102","author":"J Hoot","year":"2018","unstructured":"Hoot J, Sadeghpour EJC (2018) Nonscarring alopecia associated with vitamin D deficiency. Cutis 102(1):53\u201355","journal-title":"Cutis"},{"issue":"2","key":"6005_CR13","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/jcp.20578","volume":"207","author":"DD Bikle","year":"2006","unstructured":"Bikle DD, Elalieh H, Chang S et al (2006) Development and progression of alopecia in the vitamin D receptor null mouse. J Cell Physiol 207(2):340\u2013353","journal-title":"J Cell Physiol"},{"issue":"10","key":"6005_CR14","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1210\/me.2014-1043","volume":"28","author":"TS Lisse","year":"2014","unstructured":"Lisse TS, Saini V, Zhao H et al (2014) The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes. Mol Endocrinol 28(10):1698\u20131706","journal-title":"Mol Endocrinol"},{"issue":"4","key":"6005_CR15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1046\/j.1523-1747.2002.01727.x","volume":"118","author":"J Kong","year":"2002","unstructured":"Kong J, Li XJ, Gavin D et al (2002) Targeted expression of human vitamin D receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice. J Invest Dermatol 118(4):631\u2013638","journal-title":"J Invest Dermatol"},{"key":"6005_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.mam.2008.04.001","volume":"29","author":"AJ Brown","year":"2008","unstructured":"Brown AJ, Slatopolsky E (2008) Vitamin D analogs: Therapeutic applications and mechanisms for selectivity. Mol Aspects Med 29:433\u2013452","journal-title":"Mol Aspects Med"},{"issue":"18","key":"6005_CR17","first-page":"413","volume":"52","author":"JJ Jimenez","year":"1992","unstructured":"Jimenez JJ, Yunis AA (1992) Protection from chemotherapy-induced alopecia by 1,25-dihydroxy vitamin D3. Cancer Res 52(18):413\u2013415","journal-title":"Cancer Res"},{"key":"6005_CR18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/00001813-199904000-00007","volume":"10","author":"M Hidalgo","year":"1999","unstructured":"Hidalgo M, Rinaldi D, Medina G et al (1999) A phase I trial of topical topitriol (calcitriol, 1,25-dihydroxyvitamin D3) to prevent chemotherapy-induced alopecia. Anticancer Drugs 10:393\u2013395","journal-title":"Anticancer Drugs"},{"issue":"1","key":"6005_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1365-2133.2005.06608.x","volume":"153","author":"TO Bleiker","year":"2005","unstructured":"Bleiker TO, Nicolaou N, Traulsen J et al (2005) \u201cAtrophic telogen effluvium\u201d from cytotoxic drugs and a randomized controlled trial to investigate the possible protective effect of pretreatment with a topical vitamin D analogue in humans. Br J Dermatol 153(1):103\u2013112","journal-title":"Br J Dermatol"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-06005-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10549-020-06005-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10549-020-06005-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T13:40:08Z","timestamp":1615210808000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10549-020-06005-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["6005"],"URL":"https:\/\/doi.org\/10.1007\/s10549-020-06005-6","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]},"assertion":[{"value":"17 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"MEL and SBG declare no conflicts of interest. HD, ST, KT, EMG, EB, NT, SL, ND, NRN, RS, and EG are former\/current employees of BERG and have stock\/stock options. BB and JJJ are current members of BERG\u2019s Scientific Advisory Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}